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• W1997993463 abstract "Animal organ development requires that tissue patterning and differentiation is tightly coordinated with cell multiplication and cell cycle progression. Several variations of the cell cycle program are used by Drosophila cells at different stages during development [1Edgar B.A. Lehner C.F. Developmental control of cell cycle regulation a fly’s perspective.Science. 1996; 274: 1646-1652Crossref PubMed Scopus (222) Google Scholar, 2Follette P.J. O’Farrell P.H. Connecting cell behavior to patterning: lessons from the cell cycle.Cell. 1997; 88: 309-314Abstract Full Text Full Text PDF PubMed Scopus (25) Google Scholar]. In imaginal discs of developing larvae, cell cycle progression is controlled by a modified version of the well-characterized mammalian retinoblastoma (Rb) pathway [3Sherr C. Cancer cell cycles.Science. 1996; 274: 1672-1677Crossref PubMed Scopus (4822) Google Scholar, 4Dyson N. The regulation of E2F by pRB-family proteins.Genes Dev. 1998; 12: 2245-2262Crossref PubMed Scopus (1908) Google Scholar], which integrates signals from multiple effectors ranging from growth factors and receptors to small signaling molecules. Nitric oxide (NO), a multifunctional second messenger [5Bredt D.S. Snyder S.H. Nitric oxide a physiologic messenger molecule.Annu Rev Biochem. 1994; 63: 175-195Crossref PubMed Scopus (2083) Google Scholar], can reversibly suppress DNA synthesis and cell division [6Lepoivre M. Chenais B. Yapo A. Lemaire G. Thelander L. Tenu J.P. Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.J Biol Chem. 1990; 265: 14143-14149Abstract Full Text PDF PubMed Google Scholar, 7Kwon N.S. Stuehr D.J. Nathan C.F. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.J Exp Med. 1991; 174: 761-767Crossref PubMed Scopus (401) Google Scholar]. In developing flies, the antiproliferative action of NO is essential for regulating the balance between cell proliferation and differentiation and, ultimately, the shape and size of adult structures in the fly [8Kuzin B. Roberts I. Peunova N. Enikolopov G. Nitric oxide regulates cell proliferation during Drosophila development.Cell. 1996; 87: 639-649Abstract Full Text Full Text PDF PubMed Scopus (221) Google Scholar, 9Enikolopov G. Banerji J. Kuzin B. Nitric oxide and Drosophila development.Cell Death Differ. 1999; 6: 956-963Crossref PubMed Scopus (77) Google Scholar, 10Wingrove J.A. O’Farrell P.H. Nitric oxide contributes to behavioral, cellular, and developmental responses to low oxygen in Drosophila.Cell. 1999; 98: 105-114Abstract Full Text Full Text PDF PubMed Scopus (207) Google Scholar]. The mechanisms of the antiproliferative activity of NO in developing organisms are not known, however. We used transgenic flies expressing the Drosophila nitric oxide synthase gene (dNOS1) and/or genes encoding components of the cell cycle regulatory pathways (the Rb-like protein RBF and the E2F transcription factor complex components dE2F and dDP) combined with NOS inhibitors to address this issue. We found that manipulations of endogenous or transgenic NOS activity during imaginal disc development can enhance or suppress the effects of RBF and E2F on development of the eye. Our data suggest a role for NO in the developing imaginal eye disc via interaction with the Rb pathway." @default.
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• W1997993463 date "2000-04-01" @default.
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• W1997993463 title "Nitric oxide interacts with the retinoblastoma pathway to control eye development in Drosophila" @default.
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• W1997993463 doi "https://doi.org/10.1016/s0960-9822(00)00443-7" @default.
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