Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998016476> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1998016476 endingPage "925" @default.
- W1998016476 startingPage "923" @default.
- W1998016476 abstract "The MabA protein from Mycobacterium tuberculosis is a validated drug target. Previous structural studies of this protein showed dynamic behaviour in the catalytic site and described motion between an open 'active' holo form (with NADP) and a closed 'inactive' apo form (without NADP). Here, a mutation (G139A) is reported that leads to complete protein inactivation and freezes the catalytic site into its closed form, even in the presence of the cofactor. This observation suggests a new way to develop anti-MabA drugs via protein stabilization of the 'inactive' form." @default.
- W1998016476 created "2016-06-24" @default.
- W1998016476 creator A5000298654 @default.
- W1998016476 creator A5004980531 @default.
- W1998016476 creator A5035652134 @default.
- W1998016476 creator A5042862668 @default.
- W1998016476 creator A5070275531 @default.
- W1998016476 date "2007-07-17" @default.
- W1998016476 modified "2023-09-25" @default.
- W1998016476 title "Lack of dynamics in the MabA active site kills the enzyme activity: practical consequences for drug-design studies" @default.
- W1998016476 cites W1510483750 @default.
- W1998016476 cites W1826647060 @default.
- W1998016476 cites W2026058848 @default.
- W1998016476 cites W2039406822 @default.
- W1998016476 cites W2050136339 @default.
- W1998016476 cites W2088334665 @default.
- W1998016476 cites W2098749606 @default.
- W1998016476 cites W2104238252 @default.
- W1998016476 cites W2130007716 @default.
- W1998016476 doi "https://doi.org/10.1107/s0907444907024158" @default.
- W1998016476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17642518" @default.
- W1998016476 hasPublicationYear "2007" @default.
- W1998016476 type Work @default.
- W1998016476 sameAs 1998016476 @default.
- W1998016476 citedByCount "11" @default.
- W1998016476 countsByYear W19980164762012 @default.
- W1998016476 countsByYear W19980164762013 @default.
- W1998016476 countsByYear W19980164762015 @default.
- W1998016476 countsByYear W19980164762018 @default.
- W1998016476 crossrefType "journal-article" @default.
- W1998016476 hasAuthorship W1998016476A5000298654 @default.
- W1998016476 hasAuthorship W1998016476A5004980531 @default.
- W1998016476 hasAuthorship W1998016476A5035652134 @default.
- W1998016476 hasAuthorship W1998016476A5042862668 @default.
- W1998016476 hasAuthorship W1998016476A5070275531 @default.
- W1998016476 hasConcept C181199279 @default.
- W1998016476 hasConcept C185592680 @default.
- W1998016476 hasConcept C197957613 @default.
- W1998016476 hasConcept C2780035454 @default.
- W1998016476 hasConcept C41183919 @default.
- W1998016476 hasConcept C55493867 @default.
- W1998016476 hasConcept C71240020 @default.
- W1998016476 hasConcept C86803240 @default.
- W1998016476 hasConcept C98274493 @default.
- W1998016476 hasConceptScore W1998016476C181199279 @default.
- W1998016476 hasConceptScore W1998016476C185592680 @default.
- W1998016476 hasConceptScore W1998016476C197957613 @default.
- W1998016476 hasConceptScore W1998016476C2780035454 @default.
- W1998016476 hasConceptScore W1998016476C41183919 @default.
- W1998016476 hasConceptScore W1998016476C55493867 @default.
- W1998016476 hasConceptScore W1998016476C71240020 @default.
- W1998016476 hasConceptScore W1998016476C86803240 @default.
- W1998016476 hasConceptScore W1998016476C98274493 @default.
- W1998016476 hasIssue "8" @default.
- W1998016476 hasLocation W19980164761 @default.
- W1998016476 hasLocation W19980164762 @default.
- W1998016476 hasOpenAccess W1998016476 @default.
- W1998016476 hasPrimaryLocation W19980164761 @default.
- W1998016476 hasRelatedWork W1164537646 @default.
- W1998016476 hasRelatedWork W13108389 @default.
- W1998016476 hasRelatedWork W169735115 @default.
- W1998016476 hasRelatedWork W1953994264 @default.
- W1998016476 hasRelatedWork W2002102692 @default.
- W1998016476 hasRelatedWork W2007545289 @default.
- W1998016476 hasRelatedWork W2010596396 @default.
- W1998016476 hasRelatedWork W2074914199 @default.
- W1998016476 hasRelatedWork W2094248253 @default.
- W1998016476 hasRelatedWork W2249621633 @default.
- W1998016476 hasVolume "63" @default.
- W1998016476 isParatext "false" @default.
- W1998016476 isRetracted "false" @default.
- W1998016476 magId "1998016476" @default.
- W1998016476 workType "article" @default.