FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998016720> ?p ?o ?g. }

• W1998016720 endingPage "321" @default.
• W1998016720 startingPage "312" @default.
• W1998016720 abstract "DuringXenopusdevelopment, the early cell cycles consist of rapid oscillations between DNA synthesis and mitosis until completion of the 12th mitotic division. Then the cycle lengthens and becomes asynchronous, zygotic transcription begins, and G phases are established, a period known as the midblastula transition (MBT). Some aspects of the MBT, such as zygotic transcription, depend on acquisition of a threshold nuclear to cytoplasmic (N/C) ratio, whereas others, such as maternal cyclin E degradation, are independent of nuclear events and appear to be controlled by an autonomous maternal timer. To investigate the function of cyclin E during the early cycles, cyclin E/Cdk2 kinase activity was specifically inhibited in fertilized eggs by a truncated form of theXenopusCdk inhibitor, Xic1 (Δ34Xic1). Δ34Xic1 caused lengthening of the embryonic cell cycles that correlated with increased levels of mitotic cyclins. However, DNA synthesis was not inhibited. Several hallmarks of the MBT were delayed for several hours in Δ34Xic1-injected embryos, including the disappearance of cyclins E and A, the initiation of zygotic transcription, and the reappearance of phosphotyrosine on Cdc2. In both control and Δ34Xic1-injected embryos, cyclin E was degraded after the 12th mitotic division as zygotic transcription began, but experiments with α-amanitin show that cyclin E degradation is not dependent on zygotic transcription. Thus, the length of the early cycles and the timing of maternal cyclin degradation depend upon cyclin E/Cdk2 activity. Neither oscillations in cyclin E/Cdk2 activity during the early cycles nor the disappearance of cyclin E at the MBT were dependent on protein synthesis. These data suggest that cyclin E/Cdk2 is directly linked to an autonomous maternal timer that drives the early embryonic cell cycles until the MBT." @default.
• W1998016720 created "2016-06-24" @default.
• W1998016720 creator A5002805892 @default.
• W1998016720 creator A5020952915 @default.
• W1998016720 creator A5035705491 @default.
• W1998016720 creator A5037770228 @default.
• W1998016720 date "1997-08-01" @default.
• W1998016720 modified "2023-10-11" @default.
• W1998016720 title "A Role for Cyclin E/Cdk2 in the Timing of the Midblastula Transition inXenopusEmbryos" @default.
• W1998016720 cites W1464724343 @default.
• W1998016720 cites W1501901943 @default.
• W1998016720 cites W1965895804 @default.
• W1998016720 cites W1967891453 @default.
• W1998016720 cites W1971402068 @default.
• W1998016720 cites W1973461983 @default.
• W1998016720 cites W1979517998 @default.
• W1998016720 cites W1979669293 @default.
• W1998016720 cites W1988294339 @default.
• W1998016720 cites W1994890510 @default.
• W1998016720 cites W2009389356 @default.
• W1998016720 cites W2012130857 @default.
• W1998016720 cites W2031576542 @default.
• W1998016720 cites W2048990794 @default.
• W1998016720 cites W2059623287 @default.
• W1998016720 cites W2073239182 @default.
• W1998016720 cites W2081128958 @default.
• W1998016720 cites W2083566759 @default.
• W1998016720 cites W2089340936 @default.
• W1998016720 cites W2090303261 @default.
• W1998016720 cites W2097043033 @default.
• W1998016720 cites W2102633043 @default.
• W1998016720 cites W2103623972 @default.
• W1998016720 cites W2107332774 @default.
• W1998016720 cites W2118699566 @default.
• W1998016720 cites W2138430171 @default.
• W1998016720 cites W2153574810 @default.
• W1998016720 cites W2157451257 @default.
• W1998016720 cites W4320801100 @default.
• W1998016720 doi "https://doi.org/10.1006/dbio.1997.8647" @default.
• W1998016720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9268577" @default.
• W1998016720 hasPublicationYear "1997" @default.
• W1998016720 type Work @default.
• W1998016720 sameAs 1998016720 @default.
• W1998016720 citedByCount "64" @default.
• W1998016720 countsByYear W19980167202013 @default.
• W1998016720 countsByYear W19980167202016 @default.
• W1998016720 countsByYear W19980167202017 @default.
• W1998016720 crossrefType "journal-article" @default.
• W1998016720 hasAuthorship W1998016720A5002805892 @default.
• W1998016720 hasAuthorship W1998016720A5020952915 @default.
• W1998016720 hasAuthorship W1998016720A5035705491 @default.
• W1998016720 hasAuthorship W1998016720A5037770228 @default.
• W1998016720 hasBestOaLocation W19980167201 @default.
• W1998016720 hasConcept C11882975 @default.
• W1998016720 hasConcept C120089663 @default.
• W1998016720 hasConcept C120504264 @default.
• W1998016720 hasConcept C124320809 @default.
• W1998016720 hasConcept C1491633281 @default.
• W1998016720 hasConcept C153911025 @default.
• W1998016720 hasConcept C16438837 @default.
• W1998016720 hasConcept C17341445 @default.
• W1998016720 hasConcept C196843134 @default.
• W1998016720 hasConcept C28179978 @default.
• W1998016720 hasConcept C28748434 @default.
• W1998016720 hasConcept C29537977 @default.
• W1998016720 hasConcept C54355233 @default.
• W1998016720 hasConcept C6902291 @default.
• W1998016720 hasConcept C86803240 @default.
• W1998016720 hasConcept C87073359 @default.
• W1998016720 hasConcept C93304396 @default.
• W1998016720 hasConcept C94561458 @default.
• W1998016720 hasConcept C95444343 @default.
• W1998016720 hasConcept C9743823 @default.
• W1998016720 hasConceptScore W1998016720C11882975 @default.
• W1998016720 hasConceptScore W1998016720C120089663 @default.
• W1998016720 hasConceptScore W1998016720C120504264 @default.
• W1998016720 hasConceptScore W1998016720C124320809 @default.
• W1998016720 hasConceptScore W1998016720C1491633281 @default.
• W1998016720 hasConceptScore W1998016720C153911025 @default.
• W1998016720 hasConceptScore W1998016720C16438837 @default.
• W1998016720 hasConceptScore W1998016720C17341445 @default.
• W1998016720 hasConceptScore W1998016720C196843134 @default.
• W1998016720 hasConceptScore W1998016720C28179978 @default.
• W1998016720 hasConceptScore W1998016720C28748434 @default.
• W1998016720 hasConceptScore W1998016720C29537977 @default.
• W1998016720 hasConceptScore W1998016720C54355233 @default.
• W1998016720 hasConceptScore W1998016720C6902291 @default.
• W1998016720 hasConceptScore W1998016720C86803240 @default.
• W1998016720 hasConceptScore W1998016720C87073359 @default.
• W1998016720 hasConceptScore W1998016720C93304396 @default.
• W1998016720 hasConceptScore W1998016720C94561458 @default.
• W1998016720 hasConceptScore W1998016720C95444343 @default.
• W1998016720 hasConceptScore W1998016720C9743823 @default.
• W1998016720 hasIssue "2" @default.
• W1998016720 hasLocation W19980167201 @default.
• W1998016720 hasLocation W19980167202 @default.
• W1998016720 hasOpenAccess W1998016720 @default.
• W1998016720 hasPrimaryLocation W19980167201 @default.

• next