FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998017399> ?p ?o ?g. }

• W1998017399 endingPage "1153" @default.
• W1998017399 startingPage "1143" @default.
• W1998017399 abstract "1. The extent to which the p38 mitogen-activated protein (MAP) kinase and MAP kinase kinase (MKK)-1-signalling pathways regulate the expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) from LPS-stimulated human monocytes has been investigated and compared to the well studied cytokine tumour necrosis factor-alpha (TNF alpha). 2. Lipopolysaccharide (LPS) evoked a concentration-dependent generation of GM-CSF from human monocytes. Temporally, this effect was preceded by an increase in GM-CSF mRNA transcripts and abolished by actinomycin D and cycloheximide. 3. LPS-induced GM-CSF release and mRNA expression were associated with a rapid and time-dependent activation of p38 MAP kinase, ERK-1 and ERK-2. 4. The respective MKK-1 and p38 MAP kinase inhibitors, PD 098059 and SB 203580, maximally suppressed LPS-induced GM-CSF generation by >90%, indicating that both of these signalling cascades co-operate in the generation of this cytokine. 5. Electrophoretic mobility shift assays demonstrated that LPS increased nuclear factor kappa B (NF-kappa B) : DNA binding. SN50, an inhibitor of NF-kappa B translocation, abolished LPS-induced NF-kappaB : DNA binding and the elaboration of TNFalpha, a cytokine known to be regulated by NF-kappaB in monocytes. In contrast, SN50 failed to affect the release of GM-CSF from the same monocyte cultures. 6. Collectively, these results suggest that the generation of GM-CSF by LPS-stimulated human monocytes is regulated in a co-operative fashion by p38 MAP kinase- and MKK-1-dependent signalling pathways independently of the activation of NF-kappa B." @default.
• W1998017399 created "2016-06-24" @default.
• W1998017399 creator A5002541372 @default.
• W1998017399 creator A5018753336 @default.
• W1998017399 creator A5028297459 @default.
• W1998017399 creator A5030258071 @default.
• W1998017399 creator A5036442562 @default.
• W1998017399 creator A5040482894 @default.
• W1998017399 creator A5040751152 @default.
• W1998017399 date "2000-11-01" @default.
• W1998017399 modified "2023-10-18" @default.
• W1998017399 title "p38 MAP kinase and MKK‐1 co‐operate in the generation of GM‐CSF from LPS‐stimulated human monocytes by an NF‐κB‐independent mechanism" @default.
• W1998017399 cites W1481505452 @default.
• W1998017399 cites W1488089529 @default.
• W1998017399 cites W1490128449 @default.
• W1998017399 cites W1499093972 @default.
• W1998017399 cites W1563962170 @default.
• W1998017399 cites W1584824123 @default.
• W1998017399 cites W1587557698 @default.
• W1998017399 cites W1587892340 @default.
• W1998017399 cites W1634459475 @default.
• W1998017399 cites W1651302448 @default.
• W1998017399 cites W1660988713 @default.
• W1998017399 cites W1762121013 @default.
• W1998017399 cites W1882449923 @default.
• W1998017399 cites W1896539662 @default.
• W1998017399 cites W1912051890 @default.
• W1998017399 cites W1936540157 @default.
• W1998017399 cites W1940522739 @default.
• W1998017399 cites W1940987942 @default.
• W1998017399 cites W1964494877 @default.
• W1998017399 cites W1965583590 @default.
• W1998017399 cites W1966103571 @default.
• W1998017399 cites W1976692082 @default.
• W1998017399 cites W1980831535 @default.
• W1998017399 cites W1981049346 @default.
• W1998017399 cites W1985321490 @default.
• W1998017399 cites W2003528700 @default.
• W1998017399 cites W2010081701 @default.
• W1998017399 cites W2016686699 @default.
• W1998017399 cites W2017487826 @default.
• W1998017399 cites W2022374442 @default.
• W1998017399 cites W2027042060 @default.
• W1998017399 cites W2027347447 @default.
• W1998017399 cites W2027752681 @default.
• W1998017399 cites W2031089158 @default.
• W1998017399 cites W2031293882 @default.
• W1998017399 cites W2032731042 @default.
• W1998017399 cites W2034050426 @default.
• W1998017399 cites W2035936653 @default.
• W1998017399 cites W2041102059 @default.
• W1998017399 cites W2043234547 @default.
• W1998017399 cites W2045126708 @default.
• W1998017399 cites W2048821929 @default.
• W1998017399 cites W2055037877 @default.
• W1998017399 cites W2059359470 @default.
• W1998017399 cites W2062042301 @default.
• W1998017399 cites W2064829245 @default.
• W1998017399 cites W2077887480 @default.
• W1998017399 cites W2078655654 @default.
• W1998017399 cites W2079720391 @default.
• W1998017399 cites W2084788247 @default.
• W1998017399 cites W2085635715 @default.
• W1998017399 cites W2086262311 @default.
• W1998017399 cites W2092726661 @default.
• W1998017399 cites W2096678608 @default.
• W1998017399 cites W2101439763 @default.
• W1998017399 cites W2102966709 @default.
• W1998017399 cites W2104176092 @default.
• W1998017399 cites W2117596960 @default.
• W1998017399 cites W2119528870 @default.
• W1998017399 cites W2158528246 @default.
• W1998017399 cites W2158998343 @default.
• W1998017399 cites W2160597342 @default.
• W1998017399 cites W2238844610 @default.
• W1998017399 cites W2292202903 @default.
• W1998017399 cites W2336020536 @default.
• W1998017399 cites W2341113379 @default.
• W1998017399 cites W4313331850 @default.
• W1998017399 cites W4313333755 @default.
• W1998017399 cites W4313335080 @default.
• W1998017399 cites W4313377128 @default.
• W1998017399 cites W49853543 @default.
• W1998017399 doi "https://doi.org/10.1038/sj.bjp.0703684" @default.
• W1998017399 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1572440" @default.
• W1998017399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11082122" @default.
• W1998017399 hasPublicationYear "2000" @default.
• W1998017399 type Work @default.
• W1998017399 sameAs 1998017399 @default.
• W1998017399 citedByCount "70" @default.
• W1998017399 countsByYear W19980173992012 @default.
• W1998017399 countsByYear W19980173992013 @default.
• W1998017399 countsByYear W19980173992014 @default.
• W1998017399 countsByYear W19980173992015 @default.
• W1998017399 countsByYear W19980173992016 @default.
• W1998017399 countsByYear W19980173992017 @default.
• W1998017399 countsByYear W19980173992018 @default.
• W1998017399 countsByYear W19980173992019 @default.

• next