FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998018391> ?p ?o ?g. }

• W1998018391 endingPage "738" @default.
• W1998018391 startingPage "733" @default.
• W1998018391 abstract "Both neurological and immunological systems are vulnerable to early life exposures. Neurological disorders and atopy have been related in animals and humans. Our main objective was to assess whether multiple exposures to early life determinants remain associated with neurodevelopment after considering the potential intermediate role of atopy. A second objective was to assess whether genes associated with atopy may inform about the potential neurotoxical mechanisms. Children were members of the AMICS birth cohort in Menorca (n=418, 87% of the recruited). General cognition was measured with the McCarthy Scales at age 4 and atopy through specific IgE at age 4 and prick test at age 6; 85 single nucleotide polymorphisms (SNPs) in 16 atopy and detoxification genes were genotyped. Among the 27 risk factors assessed, lower maternal social class, maternal smoking during pregnancy, being first born, shorter breastfeeding, higher DDT levels in cord blood, and higher indoor levels of NO2 (among the non-detoxifiers by GSTP1 polymorphism) were independently associated with poorer cognition. These associations were apparently not mediated by the relation between atopy and general cognition. Among the candidate atopic genes, variants in NQ01 (a detoxification gene) and NPRS1 (related with affective disorders like anxiety and stress management) had a significant association with general cognition (p-value<0.001). However, adjustment for the corresponding SNPs did not change the association between the early life determinants and general cognition. Multiple environmental pre-natal exposures were associated with neurodevelopment independently of their role in the immunological system. Atopic genes related to neurodevelopment suggest some potential mechanisms." @default.
• W1998018391 created "2016-06-24" @default.
• W1998018391 creator A5006052429 @default.
• W1998018391 creator A5011571840 @default.
• W1998018391 creator A5025394086 @default.
• W1998018391 creator A5044129385 @default.
• W1998018391 creator A5046359435 @default.
• W1998018391 creator A5052680269 @default.
• W1998018391 creator A5063716127 @default.
• W1998018391 creator A5068139329 @default.
• W1998018391 creator A5080056003 @default.
• W1998018391 date "2010-10-01" @default.
• W1998018391 modified "2023-10-15" @default.
• W1998018391 title "Early life environment, neurodevelopment and the interrelation with atopy" @default.
• W1998018391 cites W1484854786 @default.
• W1998018391 cites W1821549997 @default.
• W1998018391 cites W1968406111 @default.
• W1998018391 cites W1975127060 @default.
• W1998018391 cites W1982286755 @default.
• W1998018391 cites W1985670077 @default.
• W1998018391 cites W1986234682 @default.
• W1998018391 cites W1996838604 @default.
• W1998018391 cites W1999460095 @default.
• W1998018391 cites W2004929470 @default.
• W1998018391 cites W2005661565 @default.
• W1998018391 cites W2015129611 @default.
• W1998018391 cites W2020403353 @default.
• W1998018391 cites W2024992356 @default.
• W1998018391 cites W2052076268 @default.
• W1998018391 cites W2062426104 @default.
• W1998018391 cites W2062855264 @default.
• W1998018391 cites W2065409294 @default.
• W1998018391 cites W2069109894 @default.
• W1998018391 cites W2070230411 @default.
• W1998018391 cites W2073592228 @default.
• W1998018391 cites W2084480028 @default.
• W1998018391 cites W2087849042 @default.
• W1998018391 cites W2093803567 @default.
• W1998018391 cites W2113559481 @default.
• W1998018391 cites W2117930025 @default.
• W1998018391 cites W2120316455 @default.
• W1998018391 cites W2121361277 @default.
• W1998018391 cites W2133118435 @default.
• W1998018391 cites W2135761538 @default.
• W1998018391 cites W2139762530 @default.
• W1998018391 cites W2151472473 @default.
• W1998018391 cites W2154140094 @default.
• W1998018391 cites W2155746270 @default.
• W1998018391 cites W2159314797 @default.
• W1998018391 cites W2159818759 @default.
• W1998018391 cites W2162647412 @default.
• W1998018391 cites W2163849189 @default.
• W1998018391 cites W2167693159 @default.
• W1998018391 cites W2170107646 @default.
• W1998018391 cites W2170196835 @default.
• W1998018391 cites W600205306 @default.
• W1998018391 doi "https://doi.org/10.1016/j.envres.2010.07.005" @default.
• W1998018391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20701904" @default.
• W1998018391 hasPublicationYear "2010" @default.
• W1998018391 type Work @default.
• W1998018391 sameAs 1998018391 @default.
• W1998018391 citedByCount "8" @default.
• W1998018391 countsByYear W19980183912012 @default.
• W1998018391 countsByYear W19980183912013 @default.
• W1998018391 countsByYear W19980183912016 @default.
• W1998018391 countsByYear W19980183912018 @default.
• W1998018391 crossrefType "journal-article" @default.
• W1998018391 hasAuthorship W1998018391A5006052429 @default.
• W1998018391 hasAuthorship W1998018391A5011571840 @default.
• W1998018391 hasAuthorship W1998018391A5025394086 @default.
• W1998018391 hasAuthorship W1998018391A5044129385 @default.
• W1998018391 hasAuthorship W1998018391A5046359435 @default.
• W1998018391 hasAuthorship W1998018391A5052680269 @default.
• W1998018391 hasAuthorship W1998018391A5063716127 @default.
• W1998018391 hasAuthorship W1998018391A5068139329 @default.
• W1998018391 hasAuthorship W1998018391A5080056003 @default.
• W1998018391 hasConcept C104317684 @default.
• W1998018391 hasConcept C118552586 @default.
• W1998018391 hasConcept C135763542 @default.
• W1998018391 hasConcept C153209595 @default.
• W1998018391 hasConcept C15744967 @default.
• W1998018391 hasConcept C169900460 @default.
• W1998018391 hasConcept C203014093 @default.
• W1998018391 hasConcept C207480886 @default.
• W1998018391 hasConcept C2777697326 @default.
• W1998018391 hasConcept C54355233 @default.
• W1998018391 hasConcept C71924100 @default.
• W1998018391 hasConcept C86803240 @default.
• W1998018391 hasConceptScore W1998018391C104317684 @default.
• W1998018391 hasConceptScore W1998018391C118552586 @default.
• W1998018391 hasConceptScore W1998018391C135763542 @default.
• W1998018391 hasConceptScore W1998018391C153209595 @default.
• W1998018391 hasConceptScore W1998018391C15744967 @default.
• W1998018391 hasConceptScore W1998018391C169900460 @default.
• W1998018391 hasConceptScore W1998018391C203014093 @default.
• W1998018391 hasConceptScore W1998018391C207480886 @default.
• W1998018391 hasConceptScore W1998018391C2777697326 @default.
• W1998018391 hasConceptScore W1998018391C54355233 @default.

• next