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- W1998020652 abstract "The increase in sodium excretion induced by isotonic saline infusion has been attributed to a redistribution of blood flow within the cortex to “salt-loosing” superficial nephrons. To test this hypothesis, mean blood flow to outer (OCF) and inner (ICF) cortex was measured in dogs before and during saline expansion, using H2-clearance rates as indicator of local blood flow. Mean total blood flow (RBF) was measured with an electromagnetic flowmeter. During infusion of 0.9 % NaCI, 30 ml/min for 30–80 min, urine flow increased from 1.1 to 7.5 ml/min, glomerular filtration rate from 39.8 to 49.1 ml/min, RBF rose from 214 to 276 ml/min, OCF from 3.43 to 3.87 ml/min and ICF from 3.50 to 3.91 ml/min. OCF/ICF did not change significantly during saline expansion. Autoregulation of local blood flow was maintained after saline loading with no change in OCF/ICF within the pressure range of autoregulation. Since massive saline infusion is followed by a parallel increase in blood flow to outer and inner cortex, it is concluded that intracortical redistribution of blood flow is not the mechanism of natriuresis during saline loading." @default.
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- W1998020652 date "1974-02-01" @default.
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- W1998020652 title "Intracortical Distribution of Renal Blood Flow during Saline Infusion in Dogs" @default.
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- W1998020652 doi "https://doi.org/10.1111/j.1748-1716.1974.tb05602.x" @default.
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