Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998028305> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1998028305 endingPage "2283" @default.
- W1998028305 startingPage "2279" @default.
- W1998028305 abstract "The effect of ethanol on the binding of conformationally rigid and labile ligands for mu and delta opioid receptors to rat brain membranes was determined. The mu ligands used for the studies were [3H]naltrexone and [3H]Tyr-D-Ala-Gly-N-MePhe-Gly-ol (DAGO), and delta ligands used were [3H]Tyr-D-Ser-Gly-Phe-Leu-Thr-OH (DSTLE) and [3H]Tyr-D-Ala-Gly-Phe-Leu (DADLE). The binding of all the opioid ligands was inhibited by ethanol in a concentration-dependent manner. For mu ligands the inhibition was greater for [3H]DAGO binding than for the binding of [3H]naltrexone. For delta ligands, the inhibition by ethanol of the binding of [3H]DADLE was greater than that of [3H]DSTLE. Fourier-transform infrared (FT-IR) spectroscopy was used to determine the conformation of opioid peptides. The data indicated that the conformation of peptides was altered in the presence of ethanol. The results suggest that ethanol inhibits the binding of both mu and delta opioid ligands with greater inhibition observed with conformationally labile ligands. Finally, the alteration in the conformation of the peptide ligands by ethanol, in addition to denaturation of the receptor protein, may also account for the observed inhibitory effect of ethanol on brain opioid receptors." @default.
- W1998028305 created "2016-06-24" @default.
- W1998028305 creator A5036666662 @default.
- W1998028305 creator A5068011791 @default.
- W1998028305 creator A5086474862 @default.
- W1998028305 date "1988-06-01" @default.
- W1998028305 modified "2023-09-27" @default.
- W1998028305 title "Effect of ethanol on the binding of conformationally rigid and labile ligands of opioid receptors to rat brain membranes" @default.
- W1998028305 cites W1526810885 @default.
- W1998028305 cites W1561827949 @default.
- W1998028305 cites W1775749144 @default.
- W1998028305 cites W1987976907 @default.
- W1998028305 cites W1995795577 @default.
- W1998028305 cites W2002165720 @default.
- W1998028305 cites W2002349100 @default.
- W1998028305 cites W2005752051 @default.
- W1998028305 cites W2017842372 @default.
- W1998028305 cites W2033314925 @default.
- W1998028305 cites W2040286733 @default.
- W1998028305 cites W2047613619 @default.
- W1998028305 cites W2047620587 @default.
- W1998028305 cites W2048611140 @default.
- W1998028305 cites W2054907229 @default.
- W1998028305 cites W2060489501 @default.
- W1998028305 cites W2064175414 @default.
- W1998028305 cites W2075322499 @default.
- W1998028305 cites W2089378207 @default.
- W1998028305 cites W2094861778 @default.
- W1998028305 cites W2165238381 @default.
- W1998028305 doi "https://doi.org/10.1016/0006-2952(88)90593-x" @default.
- W1998028305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2837233" @default.
- W1998028305 hasPublicationYear "1988" @default.
- W1998028305 type Work @default.
- W1998028305 sameAs 1998028305 @default.
- W1998028305 citedByCount "10" @default.
- W1998028305 crossrefType "journal-article" @default.
- W1998028305 hasAuthorship W1998028305A5036666662 @default.
- W1998028305 hasAuthorship W1998028305A5068011791 @default.
- W1998028305 hasAuthorship W1998028305A5086474862 @default.
- W1998028305 hasConcept C116569031 @default.
- W1998028305 hasConcept C14397066 @default.
- W1998028305 hasConcept C170493617 @default.
- W1998028305 hasConcept C185592680 @default.
- W1998028305 hasConcept C2777803847 @default.
- W1998028305 hasConcept C2777972943 @default.
- W1998028305 hasConcept C2778680407 @default.
- W1998028305 hasConcept C2779281246 @default.
- W1998028305 hasConcept C2779886867 @default.
- W1998028305 hasConcept C2780161600 @default.
- W1998028305 hasConcept C2781063702 @default.
- W1998028305 hasConcept C55493867 @default.
- W1998028305 hasConcept C71240020 @default.
- W1998028305 hasConcept C88016717 @default.
- W1998028305 hasConceptScore W1998028305C116569031 @default.
- W1998028305 hasConceptScore W1998028305C14397066 @default.
- W1998028305 hasConceptScore W1998028305C170493617 @default.
- W1998028305 hasConceptScore W1998028305C185592680 @default.
- W1998028305 hasConceptScore W1998028305C2777803847 @default.
- W1998028305 hasConceptScore W1998028305C2777972943 @default.
- W1998028305 hasConceptScore W1998028305C2778680407 @default.
- W1998028305 hasConceptScore W1998028305C2779281246 @default.
- W1998028305 hasConceptScore W1998028305C2779886867 @default.
- W1998028305 hasConceptScore W1998028305C2780161600 @default.
- W1998028305 hasConceptScore W1998028305C2781063702 @default.
- W1998028305 hasConceptScore W1998028305C55493867 @default.
- W1998028305 hasConceptScore W1998028305C71240020 @default.
- W1998028305 hasConceptScore W1998028305C88016717 @default.
- W1998028305 hasIssue "11" @default.
- W1998028305 hasLocation W19980283051 @default.
- W1998028305 hasLocation W19980283052 @default.
- W1998028305 hasOpenAccess W1998028305 @default.
- W1998028305 hasPrimaryLocation W19980283051 @default.
- W1998028305 hasRelatedWork W1979368316 @default.
- W1998028305 hasRelatedWork W2022871924 @default.
- W1998028305 hasRelatedWork W2066412857 @default.
- W1998028305 hasRelatedWork W2068598455 @default.
- W1998028305 hasRelatedWork W2075286333 @default.
- W1998028305 hasRelatedWork W2082711252 @default.
- W1998028305 hasRelatedWork W2091330110 @default.
- W1998028305 hasRelatedWork W2334628654 @default.
- W1998028305 hasRelatedWork W2418157707 @default.
- W1998028305 hasRelatedWork W2103091843 @default.
- W1998028305 hasVolume "37" @default.
- W1998028305 isParatext "false" @default.
- W1998028305 isRetracted "false" @default.
- W1998028305 magId "1998028305" @default.
- W1998028305 workType "article" @default.