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- W1998032247 endingPage "810" @default.
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- W1998032247 abstract "Type I interferons (IFNs) are pleiotropic cytokines that exert multiple effects on normal and tumor cells. These effects are supposedly mediated through the stimulation of several signal transduction pathways by type I IFNs. These include the well-studied canonical Jak-Stat pathway, largely responsible for the antiviral and growth-inhibitory activities of IFNs, as well as the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways, whose importance in IFN-induced biologic outcomes has not been precisely established. One of the effects of type I IFNs on tumor cells is the induction of programmed cell death, apoptosis, which has been studied extensively over the last decade and has been suggested to be an important effector mechanism for IFN's antitumor effects in the treatment of cancer. The aim of this review is to summarize and discuss the recent data in the field of type I IFN-induced apoptosis, with special emphasis on the molecular mechanisms of apoptosis and on the role of alternative noncanonical signaling pathways stimulated by type I IFNs in this process." @default.
- W1998032247 created "2016-06-24" @default.
- W1998032247 creator A5021288819 @default.
- W1998032247 creator A5037435178 @default.
- W1998032247 creator A5043167781 @default.
- W1998032247 date "2005-12-01" @default.
- W1998032247 modified "2023-10-16" @default.
- W1998032247 title "Alternative Signaling Pathways Regulating Type I Interferon-Induced Apoptosis" @default.
- W1998032247 cites W102321221 @default.
- W1998032247 cites W1491881129 @default.
- W1998032247 cites W1553203071 @default.
- W1998032247 cites W1569927707 @default.
- W1998032247 cites W1576660352 @default.
- W1998032247 cites W1604852883 @default.
- W1998032247 cites W1607777232 @default.
- W1998032247 cites W1676028701 @default.
- W1998032247 cites W1787971046 @default.
- W1998032247 cites W1843606951 @default.
- W1998032247 cites W1913661233 @default.
- W1998032247 cites W1966597019 @default.
- W1998032247 cites W1967912613 @default.
- W1998032247 cites W1968174514 @default.
- W1998032247 cites W1971819575 @default.
- W1998032247 cites W1976883744 @default.
- W1998032247 cites W1979231241 @default.
- W1998032247 cites W1980041786 @default.
- W1998032247 cites W1981338999 @default.
- W1998032247 cites W1983601668 @default.
- W1998032247 cites W1984547206 @default.
- W1998032247 cites W1985046929 @default.
- W1998032247 cites W1986568749 @default.
- W1998032247 cites W1994008715 @default.
- W1998032247 cites W1994828005 @default.
- W1998032247 cites W1999059713 @default.
- W1998032247 cites W1999581376 @default.
- W1998032247 cites W2000579331 @default.
- W1998032247 cites W2009620828 @default.
- W1998032247 cites W2015018036 @default.
- W1998032247 cites W2017584173 @default.
- W1998032247 cites W2018553909 @default.
- W1998032247 cites W2019355116 @default.
- W1998032247 cites W2019665042 @default.
- W1998032247 cites W2024130233 @default.
- W1998032247 cites W2025639524 @default.
- W1998032247 cites W2026211921 @default.
- W1998032247 cites W2026287156 @default.
- W1998032247 cites W2028526641 @default.
- W1998032247 cites W2028560818 @default.
- W1998032247 cites W2028953011 @default.
- W1998032247 cites W2030520525 @default.
- W1998032247 cites W2031552251 @default.
- W1998032247 cites W2032884648 @default.
- W1998032247 cites W2033294429 @default.
- W1998032247 cites W2039481177 @default.
- W1998032247 cites W2039498210 @default.
- W1998032247 cites W2040491886 @default.
- W1998032247 cites W2041911497 @default.
- W1998032247 cites W2044183610 @default.
- W1998032247 cites W2047785020 @default.
- W1998032247 cites W2050952832 @default.
- W1998032247 cites W2053001960 @default.
- W1998032247 cites W2053894673 @default.
- W1998032247 cites W2058554631 @default.
- W1998032247 cites W2059072734 @default.
- W1998032247 cites W2060926084 @default.
- W1998032247 cites W2064962625 @default.
- W1998032247 cites W2066439422 @default.
- W1998032247 cites W2071878999 @default.
- W1998032247 cites W2073028327 @default.
- W1998032247 cites W2075972578 @default.
- W1998032247 cites W2076289338 @default.
- W1998032247 cites W2080389159 @default.
- W1998032247 cites W2085546686 @default.
- W1998032247 cites W2085669605 @default.
- W1998032247 cites W2085687233 @default.
- W1998032247 cites W2086840459 @default.
- W1998032247 cites W2087123106 @default.
- W1998032247 cites W2088011467 @default.
- W1998032247 cites W2090929674 @default.
- W1998032247 cites W2090991877 @default.
- W1998032247 cites W2095094811 @default.
- W1998032247 cites W2096556604 @default.
- W1998032247 cites W2103565638 @default.
- W1998032247 cites W2109029563 @default.
- W1998032247 cites W2111091913 @default.
- W1998032247 cites W2112435732 @default.
- W1998032247 cites W2118310862 @default.
- W1998032247 cites W2119147638 @default.
- W1998032247 cites W2119885778 @default.
- W1998032247 cites W2123208560 @default.
- W1998032247 cites W2126027842 @default.
- W1998032247 cites W2128513949 @default.
- W1998032247 cites W2128657750 @default.
- W1998032247 cites W2130270853 @default.
- W1998032247 cites W2134048164 @default.
- W1998032247 cites W2142787391 @default.
- W1998032247 cites W2143067729 @default.
- W1998032247 cites W2144078346 @default.