FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998032364> ?p ?o ?g. }

• W1998032364 endingPage "5838" @default.
• W1998032364 startingPage "5830" @default.
• W1998032364 abstract "In the United States there are currently two influenza vaccine platforms approved for use in humans-conventional inactivated virus and live-attenuated influenza virus (LAIV). One of the major challenges for influenza A virus (IAV) vaccination is designing a platform that provides protection across strains. Pandemic H1N1 (pH1N1) IAV swept the globe in 2009 and crossed the species barrier, infecting swine in several countries. Pigs are a natural host for IAV and serve as a model for evaluating immune responses following vaccination and challenge. Recently, a temperature-sensitive (ts) LAIV was developed by introducing modifications in the polymerase genes of a swine-like triple reassortant (tr) virus and when paired with pandemic HA and NA, provided sterilizing immunity upon intratracheal challenge with virulent pH1N1 virus. The utility of a ts LAIV is expanded in this report to show vaccination of pigs induced a cell-mediated immune response characterized by an increased number of antigen-specific IFN-secreting cells and expanded T cell populations when compared to pigs vaccinated with a whole inactivated virus (WIV) vaccine. Following challenge, there was a significant increase in the percentage of proliferating lymphocytes in the LAIV group compared to the WIV group following restimulation with pH1N1 in vitro. Also, there was an increase in the percentage of CD4/CD8 double-positive memory T cells in LAIV vaccinated pigs compared to WIV vaccinated pigs. Hemagglutination inhibition and serum neutralization titers were significantly higher in the LAIV-vaccinated pigs compared to the WIV vaccinated pigs following the initial dose of vaccine. Taken together, these results indicate the ts LAIV vaccine, generated from a triple reassortant IAV, elicits greater cell-mediated and humoral immune responses in pigs." @default.
• W1998032364 created "2016-06-24" @default.
• W1998032364 creator A5009747501 @default.
• W1998032364 creator A5068641145 @default.
• W1998032364 creator A5071972152 @default.
• W1998032364 creator A5074907082 @default.
• W1998032364 date "2012-08-01" @default.
• W1998032364 modified "2023-09-23" @default.
• W1998032364 title "Heightened adaptive immune responses following vaccination with a temperature-sensitive, live-attenuated influenza virus compared to adjuvanted, whole-inactivated virus in pigs" @default.
• W1998032364 cites W103239798 @default.
• W1998032364 cites W1488999392 @default.
• W1998032364 cites W1490407634 @default.
• W1998032364 cites W1512372117 @default.
• W1998032364 cites W1516009011 @default.
• W1998032364 cites W1618733816 @default.
• W1998032364 cites W1968102829 @default.
• W1998032364 cites W1972767528 @default.
• W1998032364 cites W1998800513 @default.
• W1998032364 cites W2008611427 @default.
• W1998032364 cites W2013435693 @default.
• W1998032364 cites W2015607254 @default.
• W1998032364 cites W2016235141 @default.
• W1998032364 cites W2020464845 @default.
• W1998032364 cites W2021101853 @default.
• W1998032364 cites W2023019248 @default.
• W1998032364 cites W2029150236 @default.
• W1998032364 cites W2041753380 @default.
• W1998032364 cites W2048340513 @default.
• W1998032364 cites W2054479806 @default.
• W1998032364 cites W2059247743 @default.
• W1998032364 cites W2065193241 @default.
• W1998032364 cites W2071675636 @default.
• W1998032364 cites W2090270194 @default.
• W1998032364 cites W2090789808 @default.
• W1998032364 cites W2092428339 @default.
• W1998032364 cites W2117355212 @default.
• W1998032364 cites W2121009566 @default.
• W1998032364 cites W2125743639 @default.
• W1998032364 cites W2140296277 @default.
• W1998032364 cites W2144633571 @default.
• W1998032364 cites W2147714365 @default.
• W1998032364 cites W2161036972 @default.
• W1998032364 cites W2163878817 @default.
• W1998032364 cites W2164613298 @default.
• W1998032364 cites W2164655171 @default.
• W1998032364 cites W2170354602 @default.
• W1998032364 cites W2174562107 @default.
• W1998032364 cites W2336491233 @default.
• W1998032364 doi "https://doi.org/10.1016/j.vaccine.2012.07.033" @default.
• W1998032364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3743435" @default.
• W1998032364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22835742" @default.
• W1998032364 hasPublicationYear "2012" @default.
• W1998032364 type Work @default.
• W1998032364 sameAs 1998032364 @default.
• W1998032364 citedByCount "41" @default.
• W1998032364 countsByYear W19980323642013 @default.
• W1998032364 countsByYear W19980323642014 @default.
• W1998032364 countsByYear W19980323642015 @default.
• W1998032364 countsByYear W19980323642016 @default.
• W1998032364 countsByYear W19980323642017 @default.
• W1998032364 countsByYear W19980323642018 @default.
• W1998032364 countsByYear W19980323642019 @default.
• W1998032364 countsByYear W19980323642020 @default.
• W1998032364 countsByYear W19980323642021 @default.
• W1998032364 countsByYear W19980323642022 @default.
• W1998032364 countsByYear W19980323642023 @default.
• W1998032364 crossrefType "journal-article" @default.
• W1998032364 hasAuthorship W1998032364A5009747501 @default.
• W1998032364 hasAuthorship W1998032364A5068641145 @default.
• W1998032364 hasAuthorship W1998032364A5071972152 @default.
• W1998032364 hasAuthorship W1998032364A5074907082 @default.
• W1998032364 hasBestOaLocation W19980323642 @default.
• W1998032364 hasConcept C104317684 @default.
• W1998032364 hasConcept C133239900 @default.
• W1998032364 hasConcept C142724271 @default.
• W1998032364 hasConcept C159047783 @default.
• W1998032364 hasConcept C182072434 @default.
• W1998032364 hasConcept C203014093 @default.
• W1998032364 hasConcept C22070199 @default.
• W1998032364 hasConcept C2522874641 @default.
• W1998032364 hasConcept C2776872762 @default.
• W1998032364 hasConcept C2777546802 @default.
• W1998032364 hasConcept C2779134260 @default.
• W1998032364 hasConcept C2779341262 @default.
• W1998032364 hasConcept C2780689484 @default.
• W1998032364 hasConcept C3008058167 @default.
• W1998032364 hasConcept C32611913 @default.
• W1998032364 hasConcept C524204448 @default.
• W1998032364 hasConcept C54602769 @default.
• W1998032364 hasConcept C55493867 @default.
• W1998032364 hasConcept C60987743 @default.
• W1998032364 hasConcept C71924100 @default.
• W1998032364 hasConcept C86803240 @default.
• W1998032364 hasConcept C8891405 @default.
• W1998032364 hasConcept C89623803 @default.
• W1998032364 hasConceptScore W1998032364C104317684 @default.
• W1998032364 hasConceptScore W1998032364C133239900 @default.
• W1998032364 hasConceptScore W1998032364C142724271 @default.

• next