Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998048086> ?p ?o ?g. }
- W1998048086 endingPage "353" @default.
- W1998048086 startingPage "337" @default.
- W1998048086 abstract "We report evidence for a strong selection event directing the outgrowth of autoreactive B cells in spontaneous murine lupus. The event occurred shortly following the induction of the somatic hypermutation process. This conclusion is derived from extensive sequence of VH and VL loci expressed by hybridomas representing two large histone-specific clones (lineages) from an autoimmune (NZB × SWR)F1 mouse. To obtain unambiguous somatic mutational information, we devised a strategy to amplify and sequence the JH and JK clusters that flank expressed V genes. Somatic mutations in V flanking sequences of the two autoreactive clones revealed that in one clone the pattern was relatively simple: the frequency of mutation was low, and only one somatic mutation was shared by all clone members. Members of the second large histone-specific clone contained many somatic mutations in combinations that indicated numerous rounds of selection. Importantly, however, as observed with the first clone, one observed somatic mutation was shared by all clone members. Since, for each clone, all members shared only one visible mutation over extensive sequence tracts, we conclude that the autoreactive clones were derived from single percursors that had just begun to mutate their V genes. The data indicate that a strong selection event had occurred shortly after the initial acquisition of somatic mutation(s) in precursors to each clone, at a stage of development corresponding to that of the germinal center B cell approximately 1 week post immunization." @default.
- W1998048086 created "2016-06-24" @default.
- W1998048086 creator A5015062757 @default.
- W1998048086 date "1986-03-01" @default.
- W1998048086 modified "2023-10-17" @default.
- W1998048086 title "Systemic Lupus Erythematosus" @default.
- W1998048086 cites W129556044 @default.
- W1998048086 cites W1472614821 @default.
- W1998048086 cites W1498233434 @default.
- W1998048086 cites W1509130197 @default.
- W1998048086 cites W160997634 @default.
- W1998048086 cites W1638118783 @default.
- W1998048086 cites W1966171928 @default.
- W1998048086 cites W1973499778 @default.
- W1998048086 cites W1976060163 @default.
- W1998048086 cites W1976290297 @default.
- W1998048086 cites W1976619400 @default.
- W1998048086 cites W1994784564 @default.
- W1998048086 cites W1999800165 @default.
- W1998048086 cites W2010664601 @default.
- W1998048086 cites W2015322785 @default.
- W1998048086 cites W2015684771 @default.
- W1998048086 cites W2020818573 @default.
- W1998048086 cites W2028470365 @default.
- W1998048086 cites W2030200454 @default.
- W1998048086 cites W2033483715 @default.
- W1998048086 cites W2040619300 @default.
- W1998048086 cites W2047855936 @default.
- W1998048086 cites W2049404096 @default.
- W1998048086 cites W2056473394 @default.
- W1998048086 cites W2060613726 @default.
- W1998048086 cites W2064149419 @default.
- W1998048086 cites W2068196601 @default.
- W1998048086 cites W2072145209 @default.
- W1998048086 cites W2073459406 @default.
- W1998048086 cites W2083358748 @default.
- W1998048086 cites W2124782387 @default.
- W1998048086 cites W2134452794 @default.
- W1998048086 cites W2141603878 @default.
- W1998048086 cites W2142360671 @default.
- W1998048086 cites W2146203649 @default.
- W1998048086 cites W2160209304 @default.
- W1998048086 cites W2336339060 @default.
- W1998048086 cites W2336696641 @default.
- W1998048086 cites W2338721595 @default.
- W1998048086 cites W2400751648 @default.
- W1998048086 cites W2416738216 @default.
- W1998048086 cites W4238035402 @default.
- W1998048086 cites W99824467 @default.
- W1998048086 doi "https://doi.org/10.1016/s0025-7125(16)30957-9" @default.
- W1998048086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3512930" @default.
- W1998048086 hasPublicationYear "1986" @default.
- W1998048086 type Work @default.
- W1998048086 sameAs 1998048086 @default.
- W1998048086 citedByCount "18" @default.
- W1998048086 countsByYear W19980480862015 @default.
- W1998048086 countsByYear W19980480862016 @default.
- W1998048086 crossrefType "journal-article" @default.
- W1998048086 hasAuthorship W1998048086A5015062757 @default.
- W1998048086 hasConcept C104317684 @default.
- W1998048086 hasConcept C128526571 @default.
- W1998048086 hasConcept C134305767 @default.
- W1998048086 hasConcept C13514818 @default.
- W1998048086 hasConcept C159654299 @default.
- W1998048086 hasConcept C2778453870 @default.
- W1998048086 hasConcept C501734568 @default.
- W1998048086 hasConcept C54355233 @default.
- W1998048086 hasConcept C81089528 @default.
- W1998048086 hasConcept C86803240 @default.
- W1998048086 hasConcept C96926380 @default.
- W1998048086 hasConceptScore W1998048086C104317684 @default.
- W1998048086 hasConceptScore W1998048086C128526571 @default.
- W1998048086 hasConceptScore W1998048086C134305767 @default.
- W1998048086 hasConceptScore W1998048086C13514818 @default.
- W1998048086 hasConceptScore W1998048086C159654299 @default.
- W1998048086 hasConceptScore W1998048086C2778453870 @default.
- W1998048086 hasConceptScore W1998048086C501734568 @default.
- W1998048086 hasConceptScore W1998048086C54355233 @default.
- W1998048086 hasConceptScore W1998048086C81089528 @default.
- W1998048086 hasConceptScore W1998048086C86803240 @default.
- W1998048086 hasConceptScore W1998048086C96926380 @default.
- W1998048086 hasIssue "2" @default.
- W1998048086 hasLocation W19980480861 @default.
- W1998048086 hasLocation W19980480862 @default.
- W1998048086 hasOpenAccess W1998048086 @default.
- W1998048086 hasPrimaryLocation W19980480861 @default.
- W1998048086 hasRelatedWork W1971344703 @default.
- W1998048086 hasRelatedWork W1980907725 @default.
- W1998048086 hasRelatedWork W1982289564 @default.
- W1998048086 hasRelatedWork W2030816309 @default.
- W1998048086 hasRelatedWork W2056583190 @default.
- W1998048086 hasRelatedWork W2072349561 @default.
- W1998048086 hasRelatedWork W2082316630 @default.
- W1998048086 hasRelatedWork W2136877952 @default.
- W1998048086 hasRelatedWork W4213012672 @default.
- W1998048086 hasRelatedWork W4232524441 @default.
- W1998048086 hasVolume "70" @default.
- W1998048086 isParatext "false" @default.