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- W1998054693 abstract "Ionizing radiation induced acute cell death in the dentate gyrus subgranular zone (SGZ) and the subventricular zone (SVZ). Hypomyelination was also observed. The effects of mild hypothermia and hyperthermia for 4 h after irradiation (IR) were studied in postnatal day 9 rats. One hemisphere was irradiated with a single dose of 8 Gy and animals were randomized to normothermia (rectal temperature 36 degrees C for 4 h), hypothermia (32 degrees C for 4 h) or hyperthermia (39 degrees C for 4 h). Cellular injury, e.g. chromatin condensation and nitrotyrosine formation, appeared to proceed faster when the body temperature was higher. Caspase-3 activation was more pronounced in the hyperthermia group and nuclear translocation of p53 was less pronounced in the hypothermia group 6 h after IR. In the SVZ the loss of nestin-positive progenitors was more pronounced (48%) and the size was smaller (45%) in the hyperthermia group 7 days post-IR. Myelination was not different after hypo- or hyperthermia. This is the first report to demonstrate that hypothermia may be beneficial and that hyperthermia may aggravate the adverse side-effects after radiation therapy to the developing brain." @default.
- W1998054693 created "2016-06-24" @default.
- W1998054693 creator A5021905275 @default.
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- W1998054693 date "2005-08-08" @default.
- W1998054693 modified "2023-10-16" @default.
- W1998054693 title "Progenitor cell injury after irradiation to the developing brain can be modulated by mild hypothermia or hyperthermia" @default.
- W1998054693 cites W1581458838 @default.
- W1998054693 cites W1599922015 @default.
- W1998054693 cites W1680974060 @default.
- W1998054693 cites W1746095826 @default.
- W1998054693 cites W1843503887 @default.
- W1998054693 cites W1901072277 @default.
- W1998054693 cites W1963634739 @default.
- W1998054693 cites W1971747664 @default.
- W1998054693 cites W1973406593 @default.
- W1998054693 cites W1976118071 @default.
- W1998054693 cites W1979411137 @default.
- W1998054693 cites W1981284566 @default.
- W1998054693 cites W1982184322 @default.
- W1998054693 cites W1983054342 @default.
- W1998054693 cites W1985094241 @default.
- W1998054693 cites W1990096405 @default.
- W1998054693 cites W1994581375 @default.
- W1998054693 cites W1999100840 @default.
- W1998054693 cites W1999927211 @default.
- W1998054693 cites W2001446879 @default.
- W1998054693 cites W2002514998 @default.
- W1998054693 cites W2004114805 @default.
- W1998054693 cites W2004116083 @default.
- W1998054693 cites W2008102622 @default.
- W1998054693 cites W2010696830 @default.
- W1998054693 cites W2011453485 @default.
- W1998054693 cites W2013485257 @default.
- W1998054693 cites W2014642268 @default.
- W1998054693 cites W2014783528 @default.
- W1998054693 cites W2017577568 @default.
- W1998054693 cites W2023997512 @default.
- W1998054693 cites W2028415314 @default.
- W1998054693 cites W2031087975 @default.
- W1998054693 cites W2035250926 @default.
- W1998054693 cites W2035628044 @default.
- W1998054693 cites W2036158708 @default.
- W1998054693 cites W2036760484 @default.
- W1998054693 cites W2037418688 @default.
- W1998054693 cites W2037685543 @default.
- W1998054693 cites W2038362792 @default.
- W1998054693 cites W2039521897 @default.
- W1998054693 cites W2039774392 @default.
- W1998054693 cites W2040786733 @default.
- W1998054693 cites W2040881358 @default.
- W1998054693 cites W2041207883 @default.
- W1998054693 cites W2042137734 @default.
- W1998054693 cites W2043136060 @default.
- W1998054693 cites W2043796451 @default.
- W1998054693 cites W2046006021 @default.
- W1998054693 cites W2046020742 @default.
- W1998054693 cites W2046637240 @default.
- W1998054693 cites W2047559992 @default.
- W1998054693 cites W2048692124 @default.
- W1998054693 cites W2048840807 @default.
- W1998054693 cites W2049169699 @default.
- W1998054693 cites W2049382766 @default.
- W1998054693 cites W2053721606 @default.
- W1998054693 cites W2054121698 @default.
- W1998054693 cites W2054935811 @default.
- W1998054693 cites W2058812077 @default.
- W1998054693 cites W2063355012 @default.
- W1998054693 cites W2064708316 @default.
- W1998054693 cites W2067856703 @default.
- W1998054693 cites W2068050476 @default.
- W1998054693 cites W2071181288 @default.
- W1998054693 cites W2071256185 @default.
- W1998054693 cites W2075317738 @default.
- W1998054693 cites W2075777025 @default.
- W1998054693 cites W2078763668 @default.
- W1998054693 cites W2079156156 @default.
- W1998054693 cites W2079847147 @default.
- W1998054693 cites W2080698302 @default.
- W1998054693 cites W2085395100 @default.
- W1998054693 cites W2086591801 @default.
- W1998054693 cites W2088288408 @default.
- W1998054693 cites W2089034101 @default.
- W1998054693 cites W2090734831 @default.
- W1998054693 cites W2090998757 @default.
- W1998054693 cites W2091328743 @default.
- W1998054693 cites W2091712620 @default.
- W1998054693 cites W2096644118 @default.
- W1998054693 cites W2098137179 @default.
- W1998054693 cites W2102395293 @default.
- W1998054693 cites W2109277172 @default.