FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998055046> ?p ?o ?g. }

• W1998055046 endingPage "847" @default.
• W1998055046 startingPage "838" @default.
• W1998055046 abstract "Injury to endothelial cells (ECs) often results in cell retraction and gap formation. When caused by antigen aggregation or complement, this injury can be prevented by pretreatment of the ECs with IL-4, suggesting that IL-4 modifies the intercellular junction. Therefore, we investigated the effects of IL-4 on expression of intercellular junction proteins and whether such effects are required for IL-4-induced resistance of ECs against complement-mediated injury. We found that IL-4 induces upregulation of the junction protein claudin-5 in porcine ECs through activation of Jak/STAT6 and phosphorylation and translocation of FoxO1 from the nucleus to the cytoplasm. Increased claudin-5 expression resulted in increased transmembrane electrical resistance of the endothelial monolayer and participated in IL-4-induced protection of the ECs from complement injury. Down-regulation of FoxO1 using siRNA by itself caused up-regulation of claudin-5 expression and partial protection from cytotoxicity. This protection was enhanced by stimulation with IL-4. We previously reported that increased phospholipid synthesis and mitochondrial protection were required for IL-4-induced resistance of ECs against complement injury and now we demonstrate a contribution of claudin-5 expression in IL-4-induced protection." @default.
• W1998055046 created "2016-06-24" @default.
• W1998055046 creator A5009553762 @default.
• W1998055046 creator A5043649821 @default.
• W1998055046 creator A5047374406 @default.
• W1998055046 creator A5056453946 @default.
• W1998055046 creator A5075809946 @default.
• W1998055046 creator A5076551817 @default.
• W1998055046 date "2014-01-01" @default.
• W1998055046 modified "2023-10-13" @default.
• W1998055046 title "Interleukin-4 Induces Up-regulation of Endothelial Cell Claudin-5 through Activation of FoxO1" @default.
• W1998055046 cites W1510097977 @default.
• W1998055046 cites W1540448085 @default.
• W1998055046 cites W1622626646 @default.
• W1998055046 cites W1964483580 @default.
• W1998055046 cites W1973054747 @default.
• W1998055046 cites W1990814941 @default.
• W1998055046 cites W1999338173 @default.
• W1998055046 cites W2022745705 @default.
• W1998055046 cites W2034269086 @default.
• W1998055046 cites W2040042668 @default.
• W1998055046 cites W2047081723 @default.
• W1998055046 cites W2061989529 @default.
• W1998055046 cites W2069493137 @default.
• W1998055046 cites W2069546496 @default.
• W1998055046 cites W2098563852 @default.
• W1998055046 cites W2104466298 @default.
• W1998055046 cites W2104567497 @default.
• W1998055046 cites W2107282910 @default.
• W1998055046 cites W2112541489 @default.
• W1998055046 cites W2117070336 @default.
• W1998055046 cites W2117689741 @default.
• W1998055046 cites W2119303378 @default.
• W1998055046 cites W2122155213 @default.
• W1998055046 cites W2122208438 @default.
• W1998055046 cites W2122982268 @default.
• W1998055046 cites W2124707284 @default.
• W1998055046 cites W2130639482 @default.
• W1998055046 cites W2136612898 @default.
• W1998055046 cites W2139856782 @default.
• W1998055046 cites W2141075780 @default.
• W1998055046 cites W2144120552 @default.
• W1998055046 cites W2153624387 @default.
• W1998055046 cites W2162853795 @default.
• W1998055046 cites W2163505131 @default.
• W1998055046 cites W2166353463 @default.
• W1998055046 doi "https://doi.org/10.1074/jbc.m113.455766" @default.
• W1998055046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3887209" @default.
• W1998055046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24280217" @default.
• W1998055046 hasPublicationYear "2014" @default.
• W1998055046 type Work @default.
• W1998055046 sameAs 1998055046 @default.
• W1998055046 citedByCount "21" @default.
• W1998055046 countsByYear W19980550462014 @default.
• W1998055046 countsByYear W19980550462015 @default.
• W1998055046 countsByYear W19980550462016 @default.
• W1998055046 countsByYear W19980550462017 @default.
• W1998055046 countsByYear W19980550462018 @default.
• W1998055046 countsByYear W19980550462019 @default.
• W1998055046 countsByYear W19980550462020 @default.
• W1998055046 countsByYear W19980550462022 @default.
• W1998055046 crossrefType "journal-article" @default.
• W1998055046 hasAuthorship W1998055046A5009553762 @default.
• W1998055046 hasAuthorship W1998055046A5043649821 @default.
• W1998055046 hasAuthorship W1998055046A5047374406 @default.
• W1998055046 hasAuthorship W1998055046A5056453946 @default.
• W1998055046 hasAuthorship W1998055046A5075809946 @default.
• W1998055046 hasAuthorship W1998055046A5076551817 @default.
• W1998055046 hasBestOaLocation W19980550461 @default.
• W1998055046 hasConcept C104317684 @default.
• W1998055046 hasConcept C111684460 @default.
• W1998055046 hasConcept C11960822 @default.
• W1998055046 hasConcept C123012128 @default.
• W1998055046 hasConcept C127561419 @default.
• W1998055046 hasConcept C140149449 @default.
• W1998055046 hasConcept C159654299 @default.
• W1998055046 hasConcept C177779419 @default.
• W1998055046 hasConcept C185592680 @default.
• W1998055046 hasConcept C202751555 @default.
• W1998055046 hasConcept C203014093 @default.
• W1998055046 hasConcept C22615655 @default.
• W1998055046 hasConcept C51872919 @default.
• W1998055046 hasConcept C54009773 @default.
• W1998055046 hasConcept C55493867 @default.
• W1998055046 hasConcept C75217442 @default.
• W1998055046 hasConcept C79879829 @default.
• W1998055046 hasConcept C86803240 @default.
• W1998055046 hasConcept C95444343 @default.
• W1998055046 hasConceptScore W1998055046C104317684 @default.
• W1998055046 hasConceptScore W1998055046C111684460 @default.
• W1998055046 hasConceptScore W1998055046C11960822 @default.
• W1998055046 hasConceptScore W1998055046C123012128 @default.
• W1998055046 hasConceptScore W1998055046C127561419 @default.
• W1998055046 hasConceptScore W1998055046C140149449 @default.
• W1998055046 hasConceptScore W1998055046C159654299 @default.
• W1998055046 hasConceptScore W1998055046C177779419 @default.
• W1998055046 hasConceptScore W1998055046C185592680 @default.
• W1998055046 hasConceptScore W1998055046C202751555 @default.

• next