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• W1998060270 abstract "Genome-wide transcription factor (TF) binding profiles differ dramatically between cell types. However, not much is known about the relationship between cell-type-specific binding patterns and gene expression. A recent study demonstrated how the same TFs can have functional roles when binding to largely non-overlapping genomic regions in hematopoietic progenitor and mast cells. Cell-type specific binding profiles of shared TFs are therefore not merely the consequence of opportunistic and functionally irrelevant binding to accessible chromatin, but instead have the potential to make meaningful contributions to cell-type specific transcriptional programs." @default.
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• W1998060270 date "2014-10-20" @default.
• W1998060270 modified "2023-09-24" @default.
• W1998060270 title "Shared transcription factors contribute to distinct cell fates" @default.
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• W1998060270 doi "https://doi.org/10.4161/21541264.2014.978173" @default.
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