FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998061469> ?p ?o ?g. }

• W1998061469 endingPage "71" @default.
• W1998061469 startingPage "57" @default.
• W1998061469 abstract "A targeted neuropharmacological, (1)H/(13)C NMR spectroscopy and multivariate statistical approach was used to examine the effects of exogenous GABA and ligands at the GABA(A) receptor family on brain metabolism in the Guinea pig cortical tissue slice. All ligands at GABA(A) receptors generated metabolic patterns which were distinct from one another with the major variance in the data arising because of metabolic work (shown by net flux into Krebs cycle byproducts and increased metabolic pool sizes). Three major clusters of metabolic signatures were identified which corresponded to: (i) activity at phasic (synaptic) GABA(A) receptors, dominated by alpha1-containing receptors and responsive to GABA at 10 micromol/L; (ii) activity at perisynaptic receptors, dominated by response to high (40 micromol/L) GABA and the superagonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol hydrochloride, and C, activity at extrasynaptic receptors, dominated by response to low (0.1-1.0 micromol/L) GABA, zolpidem (400 nmol/L) and the non-specific allosteric modulator RO19-4603 (1 nmol/L). These results highlight the utility of a different but robust approach to study of the GABAergic system using metabolic systems analysis." @default.
• W1998061469 created "2016-06-24" @default.
• W1998061469 creator A5064784603 @default.
• W1998061469 creator A5076795620 @default.
• W1998061469 creator A5082969975 @default.
• W1998061469 creator A5089829042 @default.
• W1998061469 date "2008-12-04" @default.
• W1998061469 modified "2023-09-30" @default.
• W1998061469 title "Understanding your inhibitions: effects of GABA and GABA_Areceptor modulation on brain cortical metabolism" @default.
• W1998061469 cites W1503082749 @default.
• W1998061469 cites W1539985358 @default.
• W1998061469 cites W1557387148 @default.
• W1998061469 cites W1908131908 @default.
• W1998061469 cites W1942453306 @default.
• W1998061469 cites W1969457160 @default.
• W1998061469 cites W1975190206 @default.
• W1998061469 cites W1976892039 @default.
• W1998061469 cites W1978342290 @default.
• W1998061469 cites W1982253489 @default.
• W1998061469 cites W1996339077 @default.
• W1998061469 cites W2006712408 @default.
• W1998061469 cites W2007690691 @default.
• W1998061469 cites W2012379446 @default.
• W1998061469 cites W2014908894 @default.
• W1998061469 cites W2020215594 @default.
• W1998061469 cites W2023752814 @default.
• W1998061469 cites W2025256394 @default.
• W1998061469 cites W2026571587 @default.
• W1998061469 cites W2028774959 @default.
• W1998061469 cites W2032312348 @default.
• W1998061469 cites W2032415987 @default.
• W1998061469 cites W2032425276 @default.
• W1998061469 cites W2037731351 @default.
• W1998061469 cites W2040742860 @default.
• W1998061469 cites W2043554769 @default.
• W1998061469 cites W2043763965 @default.
• W1998061469 cites W2046952822 @default.
• W1998061469 cites W2048837966 @default.
• W1998061469 cites W2050779321 @default.
• W1998061469 cites W2052184177 @default.
• W1998061469 cites W2055805679 @default.
• W1998061469 cites W2061947653 @default.
• W1998061469 cites W2074216375 @default.
• W1998061469 cites W2076481913 @default.
• W1998061469 cites W2081575009 @default.
• W1998061469 cites W2081822887 @default.
• W1998061469 cites W2083553909 @default.
• W1998061469 cites W2089074754 @default.
• W1998061469 cites W2090521204 @default.
• W1998061469 cites W2093351626 @default.
• W1998061469 cites W2104877311 @default.
• W1998061469 cites W2105418849 @default.
• W1998061469 cites W2115717276 @default.
• W1998061469 cites W2144841925 @default.
• W1998061469 cites W2145022634 @default.
• W1998061469 cites W2168819585 @default.
• W1998061469 cites W2169205273 @default.
• W1998061469 cites W2176076159 @default.
• W1998061469 cites W2217719122 @default.
• W1998061469 cites W2299687596 @default.
• W1998061469 cites W2346482202 @default.
• W1998061469 cites W2949998354 @default.
• W1998061469 cites W4251673379 @default.
• W1998061469 doi "https://doi.org/10.1111/j.1471-4159.2008.05742.x" @default.
• W1998061469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19014380" @default.
• W1998061469 hasPublicationYear "2008" @default.
• W1998061469 type Work @default.
• W1998061469 sameAs 1998061469 @default.
• W1998061469 citedByCount "14" @default.
• W1998061469 countsByYear W19980614692012 @default.
• W1998061469 countsByYear W19980614692013 @default.
• W1998061469 countsByYear W19980614692014 @default.
• W1998061469 countsByYear W19980614692015 @default.
• W1998061469 countsByYear W19980614692020 @default.
• W1998061469 countsByYear W19980614692021 @default.
• W1998061469 countsByYear W19980614692023 @default.
• W1998061469 crossrefType "journal-article" @default.
• W1998061469 hasAuthorship W1998061469A5064784603 @default.
• W1998061469 hasAuthorship W1998061469A5076795620 @default.
• W1998061469 hasAuthorship W1998061469A5082969975 @default.
• W1998061469 hasAuthorship W1998061469A5089829042 @default.
• W1998061469 hasBestOaLocation W19980614691 @default.
• W1998061469 hasConcept C166342909 @default.
• W1998061469 hasConcept C168258287 @default.
• W1998061469 hasConcept C169760540 @default.
• W1998061469 hasConcept C170493617 @default.
• W1998061469 hasConcept C185592680 @default.
• W1998061469 hasConcept C2777123777 @default.
• W1998061469 hasConcept C2777771985 @default.
• W1998061469 hasConcept C2779177108 @default.
• W1998061469 hasConcept C2781210498 @default.
• W1998061469 hasConcept C55493867 @default.
• W1998061469 hasConcept C86803240 @default.
• W1998061469 hasConcept C98274493 @default.
• W1998061469 hasConceptScore W1998061469C166342909 @default.
• W1998061469 hasConceptScore W1998061469C168258287 @default.
• W1998061469 hasConceptScore W1998061469C169760540 @default.
• W1998061469 hasConceptScore W1998061469C170493617 @default.

• next