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• W1998073061 abstract "Substitution of oxygen with a weak hydrogen bond acceptor such as fluorine provides a single-atom modification that can have grave effects on the chemical and medicinal properties of nucleoside analogues. To that end, we present a simple and high-yielding method for the novel synthesis of 5‘-deoxy-5‘-fluoroguanosine and 5‘-deoxy-5‘-fluoroinosine utilizing an intramolecular electron-withdrawing approach. The properties of the resulting modified nucleosides, as well as the halogenated intermediates, are notable for their similarity to nucleoside analogues used in the treatment of cancer, as well as enzyme inhibitors designed to target parasitic protozoa." @default.
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• W1998073061 date "2007-09-29" @default.
• W1998073061 modified "2023-09-29" @default.
• W1998073061 title "Efficient Syntheses of 5‘-Deoxy-5‘-fluoroguanosine and -inosine" @default.
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• W1998073061 doi "https://doi.org/10.1021/jo7015778" @default.
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