FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998074100> ?p ?o ?g. }

• W1998074100 endingPage "4443" @default.
• W1998074100 startingPage "4433" @default.
• W1998074100 abstract "It has been reported that autophagy is involved in the replication of many viruses. In this study, we screened 89 medicinal plants, using an assay based on the inhibition of the formation of the Atg12-Atg5/Atg16 heterotrimer, an important regulator of autophagy, and selected Silybum marianum L. for further study. An antiviral assay indicated that silybin (S0), the major active compound of S. marianum L., can inhibit influenza A virus (IAV) infection. We later synthesized 5 silybin derivatives (S1 through S5) and found that 23-(S)-2-amino-3-phenylpropanoyl-silybin (S3) had the best activity. When we compared the polarities of the substituent groups, we found that the hydrophobicity of the substituent groups was positively correlated with their activities. We further studied the mechanisms of action of these compounds and determined that S0 and S3 also inhibited both the formation of the Atg12-Atg5/Atg16 heterotrimer and the elevated autophagy induced by IAV infection. In addition, we found that S0 and S3 could inhibit several components induced by IAV infection, including oxidative stress, the activation of extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) and IκB kinase (IKK) pathways, and the expression of autophagic genes, especially Atg7 and Atg3. All of these components have been reported to be related to the formation of the Atg12-Atg5/Atg16 heterotrimer, which might validate our screening strategy. Finally, we demonstrated that S3 can significantly reduce influenza virus replication and the associated mortality in infected mice. In conclusion, we identified 23-(S)-2-amino-3-phenylpropanoyl-silybin as a promising inhibitor of IAV infection." @default.
• W1998074100 created "2016-06-24" @default.
• W1998074100 creator A5014428274 @default.
• W1998074100 creator A5018277357 @default.
• W1998074100 creator A5024005328 @default.
• W1998074100 creator A5027145422 @default.
• W1998074100 creator A5027869185 @default.
• W1998074100 creator A5065880128 @default.
• W1998074100 creator A5077444654 @default.
• W1998074100 creator A5081675173 @default.
• W1998074100 creator A5085878157 @default.
• W1998074100 date "2013-09-01" @default.
• W1998074100 modified "2023-10-13" @default.
• W1998074100 title "Identification of 23-( <i>S</i> )-2-Amino-3-Phenylpropanoyl-Silybin as an Antiviral Agent for Influenza A Virus Infection <i>In Vitro</i> and <i>In Vivo</i>" @default.
• W1998074100 cites W1532796526 @default.
• W1998074100 cites W1805933982 @default.
• W1998074100 cites W1970619064 @default.
• W1998074100 cites W1972919132 @default.
• W1998074100 cites W1986173321 @default.
• W1998074100 cites W1990029699 @default.
• W1998074100 cites W1990204346 @default.
• W1998074100 cites W1991210241 @default.
• W1998074100 cites W2003038692 @default.
• W1998074100 cites W2003305424 @default.
• W1998074100 cites W2007296144 @default.
• W1998074100 cites W2012446252 @default.
• W1998074100 cites W2017134093 @default.
• W1998074100 cites W2020643325 @default.
• W1998074100 cites W2031693373 @default.
• W1998074100 cites W2045992894 @default.
• W1998074100 cites W2047269436 @default.
• W1998074100 cites W2049783128 @default.
• W1998074100 cites W2050419596 @default.
• W1998074100 cites W2053240007 @default.
• W1998074100 cites W2054093062 @default.
• W1998074100 cites W2064818594 @default.
• W1998074100 cites W2075272295 @default.
• W1998074100 cites W2080100430 @default.
• W1998074100 cites W2080692874 @default.
• W1998074100 cites W2083080666 @default.
• W1998074100 cites W2093527800 @default.
• W1998074100 cites W2095309525 @default.
• W1998074100 cites W2096000329 @default.
• W1998074100 cites W2098001307 @default.
• W1998074100 cites W2099980511 @default.
• W1998074100 cites W2102368840 @default.
• W1998074100 cites W2104558541 @default.
• W1998074100 cites W2104590780 @default.
• W1998074100 cites W2105089504 @default.
• W1998074100 cites W2107846243 @default.
• W1998074100 cites W2112898697 @default.
• W1998074100 cites W2115888489 @default.
• W1998074100 cites W2117038143 @default.
• W1998074100 cites W2119197454 @default.
• W1998074100 cites W2123173445 @default.
• W1998074100 cites W2125237080 @default.
• W1998074100 cites W2131023062 @default.
• W1998074100 cites W2133672825 @default.
• W1998074100 cites W2142905631 @default.
• W1998074100 cites W2143112776 @default.
• W1998074100 cites W2151716580 @default.
• W1998074100 cites W2152477480 @default.
• W1998074100 cites W2158628196 @default.
• W1998074100 cites W2162817068 @default.
• W1998074100 cites W4232837265 @default.
• W1998074100 doi "https://doi.org/10.1128/aac.00759-13" @default.
• W1998074100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3754338" @default.
• W1998074100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23836164" @default.
• W1998074100 hasPublicationYear "2013" @default.
• W1998074100 type Work @default.
• W1998074100 sameAs 1998074100 @default.
• W1998074100 citedByCount "24" @default.
• W1998074100 countsByYear W19980741002014 @default.
• W1998074100 countsByYear W19980741002015 @default.
• W1998074100 countsByYear W19980741002016 @default.
• W1998074100 countsByYear W19980741002017 @default.
• W1998074100 countsByYear W19980741002018 @default.
• W1998074100 countsByYear W19980741002019 @default.
• W1998074100 countsByYear W19980741002021 @default.
• W1998074100 countsByYear W19980741002022 @default.
• W1998074100 countsByYear W19980741002023 @default.
• W1998074100 crossrefType "journal-article" @default.
• W1998074100 hasAuthorship W1998074100A5014428274 @default.
• W1998074100 hasAuthorship W1998074100A5018277357 @default.
• W1998074100 hasAuthorship W1998074100A5024005328 @default.
• W1998074100 hasAuthorship W1998074100A5027145422 @default.
• W1998074100 hasAuthorship W1998074100A5027869185 @default.
• W1998074100 hasAuthorship W1998074100A5065880128 @default.
• W1998074100 hasAuthorship W1998074100A5077444654 @default.
• W1998074100 hasAuthorship W1998074100A5081675173 @default.
• W1998074100 hasAuthorship W1998074100A5085878157 @default.
• W1998074100 hasBestOaLocation W19980741001 @default.
• W1998074100 hasConcept C104317684 @default.
• W1998074100 hasConcept C140704245 @default.
• W1998074100 hasConcept C159047783 @default.
• W1998074100 hasConcept C184235292 @default.
• W1998074100 hasConcept C185592680 @default.
• W1998074100 hasConcept C190283241 @default.

• next