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- W1998075671 abstract "Abstract Polyphloretin phosphate (PPP) produced a dose-dependent decrease in the tone and reduction of the spontaneous phasic contractions of the longitudinal muscle of guinea-pig isolated ileum. PPP (100 μg ml−1) after a 2 min contact with the ileum decreased the contractile effects of PGE1 0·1 μM by 40·6 ± 7·4%, of PGE1 0·01 μM by 86·7 ± 3·3% and of PGF2α 0·1 μM by 62·2 ± 8·6%. After 10 min contact of PPP the contractile effect of PGE1 0·1 μM was decreased by 47·7 ± 4·7% and that of PGF2α0·1 μM by 89·6 ± 1·7%. When the contact was longer, PPP showed a pronounced after-effect in respect to the effects of PGE1 and particularly of PGF2α. PPP significantly reduced contractions to 5-HT and BaCl2, but not to acetylcholine, histamine or substance P. The type of antagonism of PGE1 by PPP was examined using cumulative concentration-effect curves for PGE1 in the presence of increasing concentrations of PPP. We conclude that on guinea-pig ileum PPP acts as a non-competitive antagonist of PGE1 and PGF2α." @default.
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- W1998075671 date "1978-09-01" @default.
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- W1998075671 title "The character of the antagonism by polyphloretin phosphate of contractions to prostaglandins E1 and F2α in guinea-pig ileum" @default.
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- W1998075671 doi "https://doi.org/10.1111/j.2042-7158.1978.tb13300.x" @default.
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