Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998079511> ?p ?o ?g. }
- W1998079511 endingPage "450" @default.
- W1998079511 startingPage "444" @default.
- W1998079511 abstract "Experimental studies have demonstrated that postischemic therapeutic interventions may delay rather than provide long-lasting neuroprotection. The purpose of this study was to determine whether mild hypothermia (33–34°C) combined with the anti-inflammatory cytokine interleukin-10 (IL-10) would protect the CA1 hippocampus 2 months after ischemia. Rats were subjected to 12.5 min of normothermic (37°C) forebrain ischemia by two-vessel occlusion followed immediately by: (a) 4 h of normothermic (37°C) reperfusion (n = 5); (b) 4 h of postischemic hypothermia (33–34°C) (n = 5); (c) 4 h of normothermia plus IL-10 (5 μg) treatment 30 min after ischemia and at 3 days (n = 5); or (d) 4 h of hypothermia plus IL-10 treatment (n = 5). Rats survived for 2 months and were perfusion fixed for quantitative histopathological assessment of CA1 hippocampus. Postischemic normothermia and hypothermia, as well as normothermia plus IL-10 treatment led to severe damage of the CA1 hippocampus. In contrast, the combined treatment of hypothermia with IL-10 treatment improved overall neuronal survival by 49% compared to normothermic ischemia (P < 0.01). These data emphasize the detrimental consequences of secondary inflammatory responses on ischemic neuronal damage after transient global ischemia. In postinjury settings where restricted durations of mild hypothermia can be induced, anti-inflammatory treatments, including IL-10, may promote chronic neuroprotection." @default.
- W1998079511 created "2016-06-24" @default.
- W1998079511 creator A5009710743 @default.
- W1998079511 creator A5011373172 @default.
- W1998079511 creator A5028148320 @default.
- W1998079511 date "1999-08-01" @default.
- W1998079511 modified "2023-10-06" @default.
- W1998079511 title "Postischemic Hypothermia and IL-10 Treatment Provide Long-Lasting Neuroprotection of CA1 Hippocampus Following Transient Global Ischemia in Rats" @default.
- W1998079511 cites W1481199079 @default.
- W1998079511 cites W1508495515 @default.
- W1998079511 cites W1548026130 @default.
- W1998079511 cites W1593714022 @default.
- W1998079511 cites W1753183749 @default.
- W1998079511 cites W1974108416 @default.
- W1998079511 cites W1980793025 @default.
- W1998079511 cites W1985315203 @default.
- W1998079511 cites W1991207312 @default.
- W1998079511 cites W1994426001 @default.
- W1998079511 cites W1999325957 @default.
- W1998079511 cites W2005012264 @default.
- W1998079511 cites W2008269957 @default.
- W1998079511 cites W2016703443 @default.
- W1998079511 cites W2021533801 @default.
- W1998079511 cites W2026989777 @default.
- W1998079511 cites W2030485098 @default.
- W1998079511 cites W2030627781 @default.
- W1998079511 cites W2031955562 @default.
- W1998079511 cites W2036755665 @default.
- W1998079511 cites W2041131288 @default.
- W1998079511 cites W2047034998 @default.
- W1998079511 cites W2049618347 @default.
- W1998079511 cites W2062794300 @default.
- W1998079511 cites W2067855097 @default.
- W1998079511 cites W2068384471 @default.
- W1998079511 cites W2076659607 @default.
- W1998079511 cites W2080656191 @default.
- W1998079511 cites W2082654914 @default.
- W1998079511 cites W2086129363 @default.
- W1998079511 cites W2086148521 @default.
- W1998079511 cites W2089172549 @default.
- W1998079511 cites W2095211398 @default.
- W1998079511 cites W2095403576 @default.
- W1998079511 cites W2098752487 @default.
- W1998079511 cites W2108097349 @default.
- W1998079511 cites W2112763282 @default.
- W1998079511 cites W2129648625 @default.
- W1998079511 cites W4293384371 @default.
- W1998079511 doi "https://doi.org/10.1006/exnr.1999.7115" @default.
- W1998079511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10415151" @default.
- W1998079511 hasPublicationYear "1999" @default.
- W1998079511 type Work @default.
- W1998079511 sameAs 1998079511 @default.
- W1998079511 citedByCount "116" @default.
- W1998079511 countsByYear W19980795112012 @default.
- W1998079511 countsByYear W19980795112013 @default.
- W1998079511 countsByYear W19980795112014 @default.
- W1998079511 countsByYear W19980795112015 @default.
- W1998079511 countsByYear W19980795112016 @default.
- W1998079511 countsByYear W19980795112017 @default.
- W1998079511 countsByYear W19980795112018 @default.
- W1998079511 countsByYear W19980795112019 @default.
- W1998079511 countsByYear W19980795112020 @default.
- W1998079511 countsByYear W19980795112021 @default.
- W1998079511 countsByYear W19980795112023 @default.
- W1998079511 crossrefType "journal-article" @default.
- W1998079511 hasAuthorship W1998079511A5009710743 @default.
- W1998079511 hasAuthorship W1998079511A5011373172 @default.
- W1998079511 hasAuthorship W1998079511A5028148320 @default.
- W1998079511 hasBestOaLocation W19980795111 @default.
- W1998079511 hasConcept C126322002 @default.
- W1998079511 hasConcept C25498285 @default.
- W1998079511 hasConcept C2777390192 @default.
- W1998079511 hasConcept C2778820722 @default.
- W1998079511 hasConcept C2781161787 @default.
- W1998079511 hasConcept C42219234 @default.
- W1998079511 hasConcept C541997718 @default.
- W1998079511 hasConcept C71924100 @default.
- W1998079511 hasConcept C98274493 @default.
- W1998079511 hasConceptScore W1998079511C126322002 @default.
- W1998079511 hasConceptScore W1998079511C25498285 @default.
- W1998079511 hasConceptScore W1998079511C2777390192 @default.
- W1998079511 hasConceptScore W1998079511C2778820722 @default.
- W1998079511 hasConceptScore W1998079511C2781161787 @default.
- W1998079511 hasConceptScore W1998079511C42219234 @default.
- W1998079511 hasConceptScore W1998079511C541997718 @default.
- W1998079511 hasConceptScore W1998079511C71924100 @default.
- W1998079511 hasConceptScore W1998079511C98274493 @default.
- W1998079511 hasIssue "2" @default.
- W1998079511 hasLocation W19980795111 @default.
- W1998079511 hasLocation W19980795112 @default.
- W1998079511 hasOpenAccess W1998079511 @default.
- W1998079511 hasPrimaryLocation W19980795111 @default.
- W1998079511 hasRelatedWork W1895742453 @default.
- W1998079511 hasRelatedWork W1980651541 @default.
- W1998079511 hasRelatedWork W1998079511 @default.
- W1998079511 hasRelatedWork W2001107596 @default.
- W1998079511 hasRelatedWork W2051086257 @default.
- W1998079511 hasRelatedWork W2078028637 @default.