FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998080141> ?p ?o ?g. }

• W1998080141 abstract "EGFR overexpression has been described in many human tumours including gastric cancer. In NSCLC patients somatic EGFR mutations, within the kinase domain of the protein, as well as gene amplification were associated with a good clinical response to EGFR inhibitors. In gastric tumours data concerning structural alterations of EGFR remains controversial. Given its possible therapeutic relevance, we aimed to determine the frequency and type of structural alterations of the EGFR gene in a series of primary gastric carcinomas.Direct sequencing of the kinase domain of the EGFR gene was performed in a series of 77 primary gastric carcinomas. FISH analysis was performed in 30 cases. Association studies between EGFR alterations and the clinical pathological features of the tumours were performed.Within the 77 primary gastric carcinomas we found two EGFR somatic mutations and several EGFR polymorphisms in exon 20. Six different intronic sequence variants of EGFR were also found. Four gastric carcinomas showed balanced polysomy or EGFR gene amplification. We verified that gastric carcinoma with alterations of EGFR (somatic mutations or copy number variation) showed a significant increase of tumour size (p = 0.0094) in comparison to wild-type EGFR carcinomas.We demonstrate that EGFR structural alterations are rare in gastric carcinoma, but whenever present, it leads to tumour growth. We considered that searching for EGFR alterations in gastric cancer is likely to be clinically important in order to identify patients susceptible to respond to tyrosine kinase inhibitors." @default.
• W1998080141 created "2016-06-24" @default.
• W1998080141 creator A5019433986 @default.
• W1998080141 creator A5023813554 @default.
• W1998080141 creator A5026242093 @default.
• W1998080141 creator A5038760927 @default.
• W1998080141 creator A5065553868 @default.
• W1998080141 creator A5083413949 @default.
• W1998080141 date "2008-01-16" @default.
• W1998080141 modified "2023-10-01" @default.
• W1998080141 title "Epidermal growth factor receptor structural alterations in gastric cancer" @default.
• W1998080141 cites W1550092936 @default.
• W1998080141 cites W1971653050 @default.
• W1998080141 cites W1972073966 @default.
• W1998080141 cites W1973071934 @default.
• W1998080141 cites W1974024530 @default.
• W1998080141 cites W1980304753 @default.
• W1998080141 cites W2032359283 @default.
• W1998080141 cites W2042556190 @default.
• W1998080141 cites W2043696829 @default.
• W1998080141 cites W2044400793 @default.
• W1998080141 cites W2052066125 @default.
• W1998080141 cites W2064047613 @default.
• W1998080141 cites W2066171378 @default.
• W1998080141 cites W2072031500 @default.
• W1998080141 cites W2075653061 @default.
• W1998080141 cites W2079275926 @default.
• W1998080141 cites W2084906142 @default.
• W1998080141 cites W2097097666 @default.
• W1998080141 cites W2111039168 @default.
• W1998080141 cites W2119930263 @default.
• W1998080141 cites W2152148281 @default.
• W1998080141 cites W2160337850 @default.
• W1998080141 cites W2161821474 @default.
• W1998080141 cites W2273270135 @default.
• W1998080141 cites W2327984703 @default.
• W1998080141 cites W2339422318 @default.
• W1998080141 cites W2414841583 @default.
• W1998080141 doi "https://doi.org/10.1186/1471-2407-8-10" @default.
• W1998080141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2244615" @default.
• W1998080141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18199332" @default.
• W1998080141 hasPublicationYear "2008" @default.
• W1998080141 type Work @default.
• W1998080141 sameAs 1998080141 @default.
• W1998080141 citedByCount "47" @default.
• W1998080141 countsByYear W19980801412012 @default.
• W1998080141 countsByYear W19980801412013 @default.
• W1998080141 countsByYear W19980801412014 @default.
• W1998080141 countsByYear W19980801412015 @default.
• W1998080141 countsByYear W19980801412016 @default.
• W1998080141 countsByYear W19980801412017 @default.
• W1998080141 countsByYear W19980801412018 @default.
• W1998080141 countsByYear W19980801412019 @default.
• W1998080141 countsByYear W19980801412020 @default.
• W1998080141 countsByYear W19980801412021 @default.
• W1998080141 countsByYear W19980801412022 @default.
• W1998080141 crossrefType "journal-article" @default.
• W1998080141 hasAuthorship W1998080141A5019433986 @default.
• W1998080141 hasAuthorship W1998080141A5023813554 @default.
• W1998080141 hasAuthorship W1998080141A5026242093 @default.
• W1998080141 hasAuthorship W1998080141A5038760927 @default.
• W1998080141 hasAuthorship W1998080141A5065553868 @default.
• W1998080141 hasAuthorship W1998080141A5083413949 @default.
• W1998080141 hasBestOaLocation W19980801411 @default.
• W1998080141 hasConcept C104317684 @default.
• W1998080141 hasConcept C121608353 @default.
• W1998080141 hasConcept C126322002 @default.
• W1998080141 hasConcept C134305767 @default.
• W1998080141 hasConcept C150194340 @default.
• W1998080141 hasConcept C2777506169 @default.
• W1998080141 hasConcept C2779438470 @default.
• W1998080141 hasConcept C2781303241 @default.
• W1998080141 hasConcept C36823959 @default.
• W1998080141 hasConcept C502942594 @default.
• W1998080141 hasConcept C54355233 @default.
• W1998080141 hasConcept C71924100 @default.
• W1998080141 hasConcept C7602840 @default.
• W1998080141 hasConcept C81439078 @default.
• W1998080141 hasConcept C86803240 @default.
• W1998080141 hasConceptScore W1998080141C104317684 @default.
• W1998080141 hasConceptScore W1998080141C121608353 @default.
• W1998080141 hasConceptScore W1998080141C126322002 @default.
• W1998080141 hasConceptScore W1998080141C134305767 @default.
• W1998080141 hasConceptScore W1998080141C150194340 @default.
• W1998080141 hasConceptScore W1998080141C2777506169 @default.
• W1998080141 hasConceptScore W1998080141C2779438470 @default.
• W1998080141 hasConceptScore W1998080141C2781303241 @default.
• W1998080141 hasConceptScore W1998080141C36823959 @default.
• W1998080141 hasConceptScore W1998080141C502942594 @default.
• W1998080141 hasConceptScore W1998080141C54355233 @default.
• W1998080141 hasConceptScore W1998080141C71924100 @default.
• W1998080141 hasConceptScore W1998080141C7602840 @default.
• W1998080141 hasConceptScore W1998080141C81439078 @default.
• W1998080141 hasConceptScore W1998080141C86803240 @default.
• W1998080141 hasIssue "1" @default.
• W1998080141 hasLocation W19980801411 @default.
• W1998080141 hasLocation W19980801412 @default.
• W1998080141 hasLocation W19980801413 @default.
• W1998080141 hasLocation W19980801414 @default.
• W1998080141 hasOpenAccess W1998080141 @default.

• next