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• W1998086227 abstract "Abstract Although mRNA expression of group IIA secretory phospholipase A 2 (sPLA 2 ‐IIA) has been implicated in responses to injury in the CNS, information on protein expression remains unclear. In this study, we investigated temporal and spatial expression of sPLA 2 ‐IIA mRNA and immunoreactivity in transient focal cerebral ischemia induced in rats by occlusion of the middle cerebral artery. Northern blot analysis showed a biphasic increase in sPLA 2 ‐IIA mRNA expression following 60‐min of ischemia–reperfusion: an early phase at 30 min and a second increase at a late phase ranging from 12 h to 14 days. In situ hybridization localized the early‐phase increase in sPLA 2 ‐IIA mRNA to the affected ischemic cortex and the late‐phase increase to the penumbral area. Besides sPLA 2 ‐IIA mRNA, glial fibrillary acidic protein (GFAP) and cyclo‐oxygenase‐2 mRNAs, but not cytosolic PLA 2 , also showed an increase in the penumbral area at 3 days after ischemia–reperfusion. Immunohistochemistry of sPLA 2 ‐IIA indicated positive cells in the penumbral area similar to the GFAP‐positive astrocytes but different from the isolectin B4‐positive microglial cells. Confocal microscopy further confirmed immunoreactivity of sPLA 2 ‐IIA in reactive astrocytes but not in microglial cells. Taken together, these results demonstrate for the first time an up‐regulation of the inflammatory sPLA 2 ‐IIA in reactive astrocytes in response to cerebral ischemia–reperfusion." @default.
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• W1998086227 date "2004-06-18" @default.
• W1998086227 modified "2023-10-11" @default.
• W1998086227 title "Induction of secretory phospholipase A2 in reactive astrocytes in response to transient focal cerebral ischemia in the rat brain" @default.
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• W1998086227 doi "https://doi.org/10.1111/j.1471-4159.2004.02540.x" @default.
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