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- W1998087966 abstract "Magnetically responsive albumin microspheres containing the proline analog, cis-hydroxyproline, were synthesized and their in-vitro physical properties were characterized. These microspheres have an average size of 1.1 ± 0.3 pm with 94% of the microspheres <2.0 pm. They are uniformly spherical and contain 67% albumin, 22% magnetite, and 8% cis-hydroxyproline. The cis-hydroxyproline is releasable during a 72-h period and demonstrates a slow, releasable pool that constitutes approximately 50% of the incorporated drug. cis-Hydroxyproline is neither chemically nor biologically altered during its incorporation into the microsphere. cis-Hydroxyproline release from microspheres results in the in vitro inhibition of collagen secretion, which is indistinguishable from unincorporated cis-hydroxyproline. In a rat-tail animal model these microspheres were selectively targeted using an external magnetic field applied to a 1.5–2.0-cm target site. Fifty to 80% of the infused microspheres were localized to this site, whereas without a magnetic field only 15–20% of the microspheres are localized to this site. cis-Hydroxyproline microspheres resulted in a 16% decrease in collagen content in a scar model when compared with untreated animals (p < 0.05). With further refinement of this method of drug delivery, clinically useful inhibition of scar formation may result." @default.
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- W1998087966 date "1991-05-01" @default.
- W1998087966 modified "2023-10-17" @default.
- W1998087966 title "Synthesis and characterization of magnetically responsive albumin microspheres containingcis-hydroxyproline for scar inhibition" @default.
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- W1998087966 doi "https://doi.org/10.1002/jor.1100090316" @default.
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