FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998093603> ?p ?o ?g. }

• W1998093603 endingPage "2144" @default.
• W1998093603 startingPage "2135" @default.
• W1998093603 abstract "Our previous work in cultured cells has shown that the maintenance of mitochondrial Ca(2+) homeostasis is essential for cell survival, and that the anti-apoptotic protein Bcl-2 is able to maintain a threshold level of mitochondrial Ca(2+) by the inhibition of permeability transition. To test whether Bcl-2 also affects the mitochondrial Na(+)-Ca(2+) exchange (NCE), a major efflux pathway for mitochondrial Ca(2+), studies using transgenic mice that overexpress Bcl-2 in the heart have been performed. NCE activity was determined as the Na(+)-dependent Ca(2+) efflux in the isolated mitochondria. Overexpression of Bcl-2 led to a significant reduction of NCE activity as well as increased resistance to permeability transition in the mitochondria of transgenic heart. This was accompanied by increased matrix Ca(2+) level, enhanced formation of NADH and enhanced oxidation of pyruvate, an NAD(+)-linked substrate. Furthermore, there was induction of cellular Ca(2+) transport proteins including the Na(+)-Ca(2+) exchanger of the sarcolemma (NCX). Bcl-2 not only stimulates NCX expression in the sarcolemma but also attenuates the Na(+)-Ca(2+) exchange in the mitochondria. These results are consistent with the protection by Bcl-2 against apoptosis in heart following ischemia/reperfusion." @default.
• W1998093603 created "2016-06-24" @default.
• W1998093603 creator A5032029170 @default.
• W1998093603 creator A5051997417 @default.
• W1998093603 creator A5061908974 @default.
• W1998093603 creator A5069575202 @default.
• W1998093603 creator A5080891161 @default.
• W1998093603 date "2001-12-01" @default.
• W1998093603 modified "2023-09-23" @default.
• W1998093603 title "Regulation of Sodium–Calcium Exchange and Mitochondrial Energetics by Bcl-2 in the Heart of Transgenic Mice" @default.
• W1998093603 cites W1550247880 @default.
• W1998093603 cites W1712887138 @default.
• W1998093603 cites W1920479129 @default.
• W1998093603 cites W1969772920 @default.
• W1998093603 cites W1993895125 @default.
• W1998093603 cites W2001014014 @default.
• W1998093603 cites W2003472250 @default.
• W1998093603 cites W2008757109 @default.
• W1998093603 cites W2026367694 @default.
• W1998093603 cites W2028023732 @default.
• W1998093603 cites W2029600989 @default.
• W1998093603 cites W2033828028 @default.
• W1998093603 cites W2044494908 @default.
• W1998093603 cites W2045965322 @default.
• W1998093603 cites W2062178098 @default.
• W1998093603 cites W2063772445 @default.
• W1998093603 cites W2069590168 @default.
• W1998093603 cites W2073156978 @default.
• W1998093603 cites W2074329998 @default.
• W1998093603 cites W2076212240 @default.
• W1998093603 cites W2076939714 @default.
• W1998093603 cites W2080163146 @default.
• W1998093603 cites W2080698860 @default.
• W1998093603 cites W2088198890 @default.
• W1998093603 cites W2088830299 @default.
• W1998093603 cites W2102584757 @default.
• W1998093603 cites W2109564403 @default.
• W1998093603 cites W2113999599 @default.
• W1998093603 cites W2118785340 @default.
• W1998093603 cites W2128697833 @default.
• W1998093603 cites W2132411546 @default.
• W1998093603 cites W2142312424 @default.
• W1998093603 cites W2147640676 @default.
• W1998093603 cites W2158326731 @default.
• W1998093603 cites W2255476717 @default.
• W1998093603 cites W23937241 @default.
• W1998093603 cites W2410237697 @default.
• W1998093603 doi "https://doi.org/10.1006/jmcc.2001.1476" @default.
• W1998093603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11735260" @default.
• W1998093603 hasPublicationYear "2001" @default.
• W1998093603 type Work @default.
• W1998093603 sameAs 1998093603 @default.
• W1998093603 citedByCount "65" @default.
• W1998093603 countsByYear W19980936032012 @default.
• W1998093603 countsByYear W19980936032013 @default.
• W1998093603 countsByYear W19980936032014 @default.
• W1998093603 countsByYear W19980936032015 @default.
• W1998093603 countsByYear W19980936032016 @default.
• W1998093603 countsByYear W19980936032017 @default.
• W1998093603 countsByYear W19980936032018 @default.
• W1998093603 countsByYear W19980936032019 @default.
• W1998093603 countsByYear W19980936032020 @default.
• W1998093603 countsByYear W19980936032021 @default.
• W1998093603 countsByYear W19980936032022 @default.
• W1998093603 crossrefType "journal-article" @default.
• W1998093603 hasAuthorship W1998093603A5032029170 @default.
• W1998093603 hasAuthorship W1998093603A5051997417 @default.
• W1998093603 hasAuthorship W1998093603A5061908974 @default.
• W1998093603 hasAuthorship W1998093603A5069575202 @default.
• W1998093603 hasAuthorship W1998093603A5080891161 @default.
• W1998093603 hasConcept C102230213 @default.
• W1998093603 hasConcept C104317684 @default.
• W1998093603 hasConcept C11701378 @default.
• W1998093603 hasConcept C13591479 @default.
• W1998093603 hasConcept C141035611 @default.
• W1998093603 hasConcept C178790620 @default.
• W1998093603 hasConcept C181199279 @default.
• W1998093603 hasConcept C185592680 @default.
• W1998093603 hasConcept C190283241 @default.
• W1998093603 hasConcept C199096232 @default.
• W1998093603 hasConcept C207200792 @default.
• W1998093603 hasConcept C2777735026 @default.
• W1998093603 hasConcept C28859421 @default.
• W1998093603 hasConcept C31573885 @default.
• W1998093603 hasConcept C519063684 @default.
• W1998093603 hasConcept C55493867 @default.
• W1998093603 hasConcept C63645605 @default.
• W1998093603 hasConcept C75520062 @default.
• W1998093603 hasConcept C79879829 @default.
• W1998093603 hasConcept C86803240 @default.
• W1998093603 hasConcept C95444343 @default.
• W1998093603 hasConcept C98539663 @default.
• W1998093603 hasConceptScore W1998093603C102230213 @default.
• W1998093603 hasConceptScore W1998093603C104317684 @default.
• W1998093603 hasConceptScore W1998093603C11701378 @default.
• W1998093603 hasConceptScore W1998093603C13591479 @default.
• W1998093603 hasConceptScore W1998093603C141035611 @default.
• W1998093603 hasConceptScore W1998093603C178790620 @default.

• next