Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998112558> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1998112558 endingPage "693" @default.
- W1998112558 startingPage "690" @default.
- W1998112558 abstract "Abstract: De novo development of food allergy is an infrequent but potentially serious complication of transplantation. An increased prevalence of food allergy noted specifically in children receiving tacrolimus immunosuppression supports the hypothesis that selective suppression of Th1 lymphocytes by the IL‐2 inhibitor immunosuppressants CsA, and the more potent drug, tacrolimus , promotes Th2 lymphocytes and an allergic immune response. This study was undertaken to characterize the IgE‐mediated immune response, in CsA and tacrolimus‐treated, post‐OLT children. Thirty children and adolescents aged 1.9–21 yr, mean: 10.6 yr, (6.4 yr post‐tx.) were studied. Immunosuppression‐CsA: 10 patients, tacrolimus; 20 patients. Blood eosinophils, total IgE levels and specific IgE antibodies (Immulite 2000 Allergy; Diagnostic Products Corp., Los Angeles, CA, USA) to a panel of food and inhaled allergens were measured and correlated with clinical symptoms of allergy. Eosinophilia (>500/mm 3 ) range: 599–3125, mean: 1294, was present in 10/20 of patients treated with tacrolimus and 1/10 treated with CsA. IgE levels were elevated in eight of these 10 tacrolimus‐treated patients and in two CsA patients ; five were <3 yr of age and IgE levels ranged from 54 to 111 IU/mL (mean: 83), normal for age <45 IU/mL and five were ≥9 yr and IgE levels ranged from 134 to 1606 IU/mL (mean: 557), normal for age <87 IU/mL. Specific IgE levels to a wide panel of food allergens were positive in five tacrolimus‐treated patients and to both food and inhaled allergens in three patients (two tacrolimus‐treated, one CsA). Four children (tacrolimus‐treated) had symptoms of food allergy . None had a family history of allergy. Eosinophilia is present in up to 50% of children and adolescents receiving tacrolimus immunosuppression. The majority of these patients also have elevated levels of total and specific (mainly to food allergens) IgE antibodies. Most patients are asymptomatic and do not manifest food allergy or asthma." @default.
- W1998112558 created "2016-06-24" @default.
- W1998112558 creator A5007734831 @default.
- W1998112558 creator A5040467407 @default.
- W1998112558 creator A5091133796 @default.
- W1998112558 date "2006-05-09" @default.
- W1998112558 modified "2023-10-13" @default.
- W1998112558 title "Tacrolimus immunosuppression - An association with asymptomatic eosinophilia and elevated total and specific IgE levels" @default.
- W1998112558 cites W1991686402 @default.
- W1998112558 cites W2056893720 @default.
- W1998112558 cites W2067891708 @default.
- W1998112558 cites W2074822823 @default.
- W1998112558 cites W2094195890 @default.
- W1998112558 cites W2171516474 @default.
- W1998112558 cites W2331227052 @default.
- W1998112558 cites W2333550304 @default.
- W1998112558 cites W2405318612 @default.
- W1998112558 doi "https://doi.org/10.1111/j.1399-3046.2006.00542.x" @default.
- W1998112558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16911492" @default.
- W1998112558 hasPublicationYear "2006" @default.
- W1998112558 type Work @default.
- W1998112558 sameAs 1998112558 @default.
- W1998112558 citedByCount "60" @default.
- W1998112558 countsByYear W19981125582012 @default.
- W1998112558 countsByYear W19981125582013 @default.
- W1998112558 countsByYear W19981125582014 @default.
- W1998112558 countsByYear W19981125582015 @default.
- W1998112558 countsByYear W19981125582016 @default.
- W1998112558 countsByYear W19981125582017 @default.
- W1998112558 countsByYear W19981125582018 @default.
- W1998112558 countsByYear W19981125582019 @default.
- W1998112558 countsByYear W19981125582020 @default.
- W1998112558 countsByYear W19981125582021 @default.
- W1998112558 countsByYear W19981125582022 @default.
- W1998112558 countsByYear W19981125582023 @default.
- W1998112558 crossrefType "journal-article" @default.
- W1998112558 hasAuthorship W1998112558A5007734831 @default.
- W1998112558 hasAuthorship W1998112558A5040467407 @default.
- W1998112558 hasAuthorship W1998112558A5091133796 @default.
- W1998112558 hasConcept C126322002 @default.
- W1998112558 hasConcept C141105273 @default.
- W1998112558 hasConcept C159654299 @default.
- W1998112558 hasConcept C203014093 @default.
- W1998112558 hasConcept C207480886 @default.
- W1998112558 hasConcept C2776027960 @default.
- W1998112558 hasConcept C2777129736 @default.
- W1998112558 hasConcept C2777910003 @default.
- W1998112558 hasConcept C2780252810 @default.
- W1998112558 hasConcept C2780648854 @default.
- W1998112558 hasConcept C2909675724 @default.
- W1998112558 hasConcept C2911091166 @default.
- W1998112558 hasConcept C71924100 @default.
- W1998112558 hasConcept C8891405 @default.
- W1998112558 hasConcept C90924648 @default.
- W1998112558 hasConceptScore W1998112558C126322002 @default.
- W1998112558 hasConceptScore W1998112558C141105273 @default.
- W1998112558 hasConceptScore W1998112558C159654299 @default.
- W1998112558 hasConceptScore W1998112558C203014093 @default.
- W1998112558 hasConceptScore W1998112558C207480886 @default.
- W1998112558 hasConceptScore W1998112558C2776027960 @default.
- W1998112558 hasConceptScore W1998112558C2777129736 @default.
- W1998112558 hasConceptScore W1998112558C2777910003 @default.
- W1998112558 hasConceptScore W1998112558C2780252810 @default.
- W1998112558 hasConceptScore W1998112558C2780648854 @default.
- W1998112558 hasConceptScore W1998112558C2909675724 @default.
- W1998112558 hasConceptScore W1998112558C2911091166 @default.
- W1998112558 hasConceptScore W1998112558C71924100 @default.
- W1998112558 hasConceptScore W1998112558C8891405 @default.
- W1998112558 hasConceptScore W1998112558C90924648 @default.
- W1998112558 hasIssue "6" @default.
- W1998112558 hasLocation W19981125581 @default.
- W1998112558 hasLocation W19981125582 @default.
- W1998112558 hasOpenAccess W1998112558 @default.
- W1998112558 hasPrimaryLocation W19981125581 @default.
- W1998112558 hasRelatedWork W2003921494 @default.
- W1998112558 hasRelatedWork W2073742890 @default.
- W1998112558 hasRelatedWork W2327110598 @default.
- W1998112558 hasRelatedWork W2384248322 @default.
- W1998112558 hasRelatedWork W2386104594 @default.
- W1998112558 hasRelatedWork W2604110409 @default.
- W1998112558 hasRelatedWork W2973764369 @default.
- W1998112558 hasRelatedWork W3150855330 @default.
- W1998112558 hasRelatedWork W3207196874 @default.
- W1998112558 hasRelatedWork W4200557508 @default.
- W1998112558 hasVolume "10" @default.
- W1998112558 isParatext "false" @default.
- W1998112558 isRetracted "false" @default.
- W1998112558 magId "1998112558" @default.
- W1998112558 workType "article" @default.