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- W1998114329 abstract "Published evidence compiled in this review supports the hypothesis that the development, progression, and responsiveness to prevention and therapy of the most common human cancers is strongly influenced, if not entirely orchestrated, by an imbalance in stimulatory and inhibitory neurotransmission. The neurotransmitters acetylcholine, adrenaline, and noradrenaline of the autonomic nervous system act as powerful upstream regulators that orchestrate numerous cell and tissue functions, by releasing growth factors, angiogenesis factors and metastasis factors, arachidonic acid, proinflammatory cytokines, and local neurotransmitters from cancer cells and their microenvironment. In addition, they modulate proliferation, apoptosis, angiogenesis, and metastasis of cancer directly by intracellular signaling downstream of neurotransmitter receptors. Nicotine and the tobacco-specific nitrosamines have the documented ability to hyperstimulate neurotransmission by both branches of the autonomic nervous system. The expression and function of these neurotransmitter pathways are cell type specific. Lifestyle, diet, diseases, stress, and pharmacological treatments modulate the expression and responsiveness of neurotransmitter pathways. Current preclinical testing systems fail to incorporate the modulating effects of neurotransmission on the responsiveness to anticancer agents and should be amended accordingly. The neurotransmitter γ-aminobutyric acid has a strong inhibitory function on sympathicus-driven cancers whereas stimulators of cyclic adenosine monophosphate/protein kinase A signaling have strong inhibitory function on parasympathicus-driven cancers. Marker-guided restoration of the physiological balance in stimulatory and inhibitory neurotransmission represents a promising and hitherto neglected strategy for the prevention and therapy of neurotransmitter-responsive cancers." @default.
- W1998114329 created "2016-06-24" @default.
- W1998114329 creator A5069875961 @default.
- W1998114329 date "2008-08-01" @default.
- W1998114329 modified "2023-10-11" @default.
- W1998114329 title "Neurotransmission and cancer: implications for prevention and therapy" @default.
- W1998114329 cites W1257486597 @default.
- W1998114329 cites W1559110433 @default.
- W1998114329 cites W1701430602 @default.
- W1998114329 cites W1858702144 @default.
- W1998114329 cites W1893651774 @default.
- W1998114329 cites W1964749017 @default.
- W1998114329 cites W1965153645 @default.
- W1998114329 cites W1966155757 @default.
- W1998114329 cites W1970127699 @default.
- W1998114329 cites W1971416717 @default.
- W1998114329 cites W1972547379 @default.
- W1998114329 cites W1974715317 @default.
- W1998114329 cites W1976436028 @default.
- W1998114329 cites W1977279815 @default.
- W1998114329 cites W1981259030 @default.
- W1998114329 cites W1981454105 @default.
- W1998114329 cites W1988078905 @default.
- W1998114329 cites W1991329538 @default.
- W1998114329 cites W1992183400 @default.
- W1998114329 cites W1992318001 @default.
- W1998114329 cites W1996480893 @default.
- W1998114329 cites W2000173623 @default.
- W1998114329 cites W2000199416 @default.
- W1998114329 cites W2003726198 @default.
- W1998114329 cites W2004343290 @default.
- W1998114329 cites W2005563893 @default.
- W1998114329 cites W2005601925 @default.
- W1998114329 cites W2007114231 @default.
- W1998114329 cites W2007188131 @default.
- W1998114329 cites W2008685135 @default.
- W1998114329 cites W2010426850 @default.
- W1998114329 cites W2011826559 @default.
- W1998114329 cites W2012475172 @default.
- W1998114329 cites W2013032315 @default.
- W1998114329 cites W2013064129 @default.
- W1998114329 cites W2015670731 @default.
- W1998114329 cites W2016820356 @default.
- W1998114329 cites W2019408299 @default.
- W1998114329 cites W2020961525 @default.
- W1998114329 cites W2022502406 @default.
- W1998114329 cites W2023283315 @default.
- W1998114329 cites W2023833232 @default.
- W1998114329 cites W2024100487 @default.
- W1998114329 cites W2024529818 @default.
- W1998114329 cites W2027981753 @default.
- W1998114329 cites W2028933689 @default.
- W1998114329 cites W2030864705 @default.
- W1998114329 cites W2031056915 @default.
- W1998114329 cites W2034249705 @default.
- W1998114329 cites W2036422056 @default.
- W1998114329 cites W2041393283 @default.
- W1998114329 cites W2041800958 @default.
- W1998114329 cites W2044573147 @default.
- W1998114329 cites W2044754796 @default.
- W1998114329 cites W2046317081 @default.
- W1998114329 cites W2047658647 @default.
- W1998114329 cites W2048294916 @default.
- W1998114329 cites W2049391505 @default.
- W1998114329 cites W2050070510 @default.
- W1998114329 cites W2055481234 @default.
- W1998114329 cites W2055762844 @default.
- W1998114329 cites W2058284416 @default.
- W1998114329 cites W2060176852 @default.
- W1998114329 cites W2069336962 @default.
- W1998114329 cites W2072616138 @default.
- W1998114329 cites W2074571303 @default.
- W1998114329 cites W2077845824 @default.
- W1998114329 cites W2079157591 @default.
- W1998114329 cites W2079445758 @default.
- W1998114329 cites W2079588482 @default.
- W1998114329 cites W2084382829 @default.
- W1998114329 cites W2085210051 @default.
- W1998114329 cites W2086296564 @default.
- W1998114329 cites W2086954578 @default.
- W1998114329 cites W2087429292 @default.
- W1998114329 cites W2087757403 @default.
- W1998114329 cites W2087978510 @default.
- W1998114329 cites W2090529845 @default.
- W1998114329 cites W2094760990 @default.
- W1998114329 cites W2096051634 @default.
- W1998114329 cites W2101324933 @default.
- W1998114329 cites W2104364052 @default.
- W1998114329 cites W2105870845 @default.
- W1998114329 cites W2105891535 @default.
- W1998114329 cites W2111627512 @default.
- W1998114329 cites W2112497917 @default.
- W1998114329 cites W2120491276 @default.
- W1998114329 cites W2121104475 @default.
- W1998114329 cites W2122212067 @default.
- W1998114329 cites W2123207674 @default.
- W1998114329 cites W2126726491 @default.
- W1998114329 cites W2129227777 @default.