Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998121259> ?p ?o ?g. }
- W1998121259 endingPage "883" @default.
- W1998121259 startingPage "873" @default.
- W1998121259 abstract "Neurons may be particularly sensitive to disruptions in transcription factor trafficking. Survival and injury signals must traverse dendrites or axons, in addition to soma, to affect nuclear transcriptional responses. Transcription factors exhibit continued nucleocytoplasmic shuttling; the predominant localization is regulated by binding to anchoring proteins that mask nuclear localization/export signals and/or target the factor for degradation. Two functional groups of karyopherins, importins and exportins, mediate RanGTPase-dependent transport through the nuclear pore. A growing number of recent studies, in Alzheimer, Parkinson, and Lewy body diseases, amyotrophic lateral sclerosis, and human immunodeficiency virus encephalitis, implicate aberrant cytoplasmic localization of transcription factors and their regulatory kinases in degenerating neurons. Potential mechanisms include impaired nuclear import, enhanced export, suppression of degradation, and sequestration in protein aggregates or organelles and may reflect unmasking of alternative cytoplasmic functions, both physiologic and pathologic. Some nuclear factors also function in mitochondria, and importins are also involved in axonal protein trafficking. Detrimental consequences of a decreased nuclear to cytoplasmic balance include suppression of neuroprotective transcription mediated by cAMP- and electrophile/antioxidant-response elements and gain of toxic cytoplasmic effects. Studying the pathophysiologic mechanisms regulating transcription factor localization should facilitate strategies to bypass deficits and restore adaptive neuroprotective transcriptional responses." @default.
- W1998121259 created "2016-06-24" @default.
- W1998121259 creator A5018863416 @default.
- W1998121259 creator A5040366821 @default.
- W1998121259 creator A5060252949 @default.
- W1998121259 creator A5067062682 @default.
- W1998121259 creator A5078904678 @default.
- W1998121259 date "2007-10-01" @default.
- W1998121259 modified "2023-10-05" @default.
- W1998121259 title "Location, Location, Location" @default.
- W1998121259 cites W148434512 @default.
- W1998121259 cites W1537390295 @default.
- W1998121259 cites W1604468403 @default.
- W1998121259 cites W1608612061 @default.
- W1998121259 cites W1760852870 @default.
- W1998121259 cites W1958301018 @default.
- W1998121259 cites W1962365951 @default.
- W1998121259 cites W1965498112 @default.
- W1998121259 cites W1966994444 @default.
- W1998121259 cites W1969292797 @default.
- W1998121259 cites W1971851666 @default.
- W1998121259 cites W1978679947 @default.
- W1998121259 cites W1978932179 @default.
- W1998121259 cites W1981232919 @default.
- W1998121259 cites W1985332887 @default.
- W1998121259 cites W1987516659 @default.
- W1998121259 cites W1989524724 @default.
- W1998121259 cites W1990547924 @default.
- W1998121259 cites W1990586782 @default.
- W1998121259 cites W1992476409 @default.
- W1998121259 cites W1993196664 @default.
- W1998121259 cites W1993635466 @default.
- W1998121259 cites W1998265781 @default.
- W1998121259 cites W1999330214 @default.
- W1998121259 cites W2000465409 @default.
- W1998121259 cites W2003618511 @default.
- W1998121259 cites W2004784950 @default.
- W1998121259 cites W2006232414 @default.
- W1998121259 cites W2006552879 @default.
- W1998121259 cites W2007429564 @default.
- W1998121259 cites W2007480912 @default.
- W1998121259 cites W2007604900 @default.
- W1998121259 cites W2008661368 @default.
- W1998121259 cites W2009229814 @default.
- W1998121259 cites W2011611467 @default.
- W1998121259 cites W2012797849 @default.
- W1998121259 cites W2014515633 @default.
- W1998121259 cites W2023812320 @default.
- W1998121259 cites W2026119731 @default.
- W1998121259 cites W2028028744 @default.
- W1998121259 cites W2031846388 @default.
- W1998121259 cites W2033318695 @default.
- W1998121259 cites W2038126588 @default.
- W1998121259 cites W2039474189 @default.
- W1998121259 cites W2045023032 @default.
- W1998121259 cites W2045342373 @default.
- W1998121259 cites W2045360986 @default.
- W1998121259 cites W2045371968 @default.
- W1998121259 cites W2046431926 @default.
- W1998121259 cites W2047690887 @default.
- W1998121259 cites W2049485403 @default.
- W1998121259 cites W2051909217 @default.
- W1998121259 cites W2055336928 @default.
- W1998121259 cites W2058530681 @default.
- W1998121259 cites W2062404345 @default.
- W1998121259 cites W2063127214 @default.
- W1998121259 cites W2066952414 @default.
- W1998121259 cites W2068099929 @default.
- W1998121259 cites W2068412840 @default.
- W1998121259 cites W2070939832 @default.
- W1998121259 cites W2073019193 @default.
- W1998121259 cites W2075228897 @default.
- W1998121259 cites W2075488235 @default.
- W1998121259 cites W2084644507 @default.
- W1998121259 cites W2086997247 @default.
- W1998121259 cites W2091027054 @default.
- W1998121259 cites W2095605427 @default.
- W1998121259 cites W2096557110 @default.
- W1998121259 cites W2096707074 @default.
- W1998121259 cites W2099685145 @default.
- W1998121259 cites W2109628664 @default.
- W1998121259 cites W2110933512 @default.
- W1998121259 cites W2115338196 @default.
- W1998121259 cites W2117209575 @default.
- W1998121259 cites W2117551116 @default.
- W1998121259 cites W2118425983 @default.
- W1998121259 cites W2118898883 @default.
- W1998121259 cites W2137757938 @default.
- W1998121259 cites W2139267086 @default.
- W1998121259 cites W2146267270 @default.
- W1998121259 cites W2151464528 @default.
- W1998121259 cites W2157672366 @default.
- W1998121259 cites W2158124942 @default.
- W1998121259 cites W2159112619 @default.
- W1998121259 cites W2161727574 @default.
- W1998121259 cites W2167091449 @default.
- W1998121259 cites W2167843940 @default.
- W1998121259 cites W2167850337 @default.