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• W1998133320 endingPage "e9193" @default.
• W1998133320 startingPage "e9193" @default.
• W1998133320 abstract "Excessive activity of dendritic cells (DCs) is postulated as a central disease mechanism in Systemic Lupus Erythematosus (SLE). Vitamin D is known to reduce responsiveness of healthy donor DCs to the stimulatory effects of Type I IFN. As vitamin D deficiency is reportedly common in SLE, we hypothesized that vitamin D might play a regulatory role in the IFNalpha amplification loop in SLE. Our goals were to investigate the relationship between vitamin D levels and disease activity in SLE patients and to investigate the effects of vitamin D on DC activation and expression of IFNalpha-regulated genes in vitro.In this study, 25-OH vitamin D (25-D) levels were measured in 198 consecutively recruited SLE patients. Respectively, 29.3% and 11.8% of African American and Hispanic SLE patient had 25-D levels <10 ng/ml. The degree of vitamin D deficiency correlated inversely with disease activity; R = -.234, p = .002. In 19 SLE patients stratified by 25-D levels, there were no differences between circulating DC number and phenotype. Monocyte-derived DCs (MDDCs) of SLE patients were normally responsive to the regulatory effects of vitamin D in vitro as evidenced by decreased activation in response to LPS stimulation in the presence of 1,25-D. Additionally, vitamin D conditioning reduced expression of IFNalpha-regulated genes by healthy donor and SLE MDDCs in response to factors in activating SLE plasma.We report on severe 25-D deficiency in a substantial percentage of SLE patients tested and demonstrate an inverse correlation with disease activity. Our results suggest that vitamin D supplementation will contribute to restoring immune homeostasis in SLE patients through its inhibitory effects on DC maturation and activation. We are encouraged to support the importance of adequate vitamin D supplementation and the need for a clinical trial to assess whether vitamin D supplementation affects IFNalpha activity in vivo and, most importantly, improves clinical outcome." @default.
• W1998133320 created "2016-06-24" @default.
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• W1998133320 date "2010-02-16" @default.
• W1998133320 modified "2023-10-15" @default.
• W1998133320 title "The Impact of Vitamin D on Dendritic Cell Function in Patients with Systemic Lupus Erythematosus" @default.
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• W1998133320 doi "https://doi.org/10.1371/journal.pone.0009193" @default.
• W1998133320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2821911" @default.
• W1998133320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20169063" @default.
• W1998133320 hasPublicationYear "2010" @default.
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