Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998136977> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1998136977 endingPage "271" @default.
- W1998136977 startingPage "263" @default.
- W1998136977 abstract "Prostaglandin E1 (PGE1) shows various pharmacological activities including anti-inflammation. However, the rapid metabolization and inactivation of the intravenously administered PGE1 during the first passage through the lungs result in significant non-compliance in clinical trials which greatly limits its application. The aim of this work was to prepare the lipid nanoparticles loading PGE1 to improve its anti-inflammatory effect with low side-effect. The experimental results showed that PGE1 loaded lipid nanoparticles (PLNs) could be successfully prepared by high pressure homogenization with particle size 68.1 ± 4.7 nm, zeta potential −3.32 ± 0.37 mV and entrapment efficiency 92.1 ± 1.3%. PLNs exhibited a sustained release with low burst drug release. PLNs could improve the inhibition effects of PGE1 on lipopolysaccharides (LPS)-induced TNF-α expression on macrophage RAW264.7 cells, and improve the inhibition of lymphocyte to endothelial cell adhesion and ICAM-1 adhesion molecule expression on HUVEC and MDA-MB-468 cell membrane. No allergenicity, vascular and muscle irritation were induced in animals by PLNs even at double of the highest drug concentration of clinical infusion. As a result, PLNs could be a more potential delivery system for PGE1 in the treatment of inflammation-related diseases." @default.
- W1998136977 created "2016-06-24" @default.
- W1998136977 creator A5048249240 @default.
- W1998136977 creator A5074151795 @default.
- W1998136977 creator A5077681133 @default.
- W1998136977 creator A5090991197 @default.
- W1998136977 date "2010-03-01" @default.
- W1998136977 modified "2023-10-16" @default.
- W1998136977 title "Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect" @default.
- W1998136977 cites W1557197959 @default.
- W1998136977 cites W1591941989 @default.
- W1998136977 cites W1972614191 @default.
- W1998136977 cites W1978980785 @default.
- W1998136977 cites W1984290024 @default.
- W1998136977 cites W1996202220 @default.
- W1998136977 cites W2007893172 @default.
- W1998136977 cites W2013997434 @default.
- W1998136977 cites W2015879870 @default.
- W1998136977 cites W2022025132 @default.
- W1998136977 cites W2026758996 @default.
- W1998136977 cites W2033628234 @default.
- W1998136977 cites W2044609602 @default.
- W1998136977 cites W2045540954 @default.
- W1998136977 cites W2051820513 @default.
- W1998136977 cites W2053007057 @default.
- W1998136977 cites W2056764794 @default.
- W1998136977 cites W2058792513 @default.
- W1998136977 cites W2060883810 @default.
- W1998136977 cites W2062896966 @default.
- W1998136977 cites W2067359740 @default.
- W1998136977 cites W2069852241 @default.
- W1998136977 cites W2079286805 @default.
- W1998136977 cites W2090990359 @default.
- W1998136977 cites W2099463369 @default.
- W1998136977 cites W2123112037 @default.
- W1998136977 cites W2147619769 @default.
- W1998136977 cites W2163841415 @default.
- W1998136977 cites W2324841714 @default.
- W1998136977 cites W2747628873 @default.
- W1998136977 cites W4234317413 @default.
- W1998136977 doi "https://doi.org/10.1016/j.ijpharm.2009.12.019" @default.
- W1998136977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20006690" @default.
- W1998136977 hasPublicationYear "2010" @default.
- W1998136977 type Work @default.
- W1998136977 sameAs 1998136977 @default.
- W1998136977 citedByCount "26" @default.
- W1998136977 countsByYear W19981369772012 @default.
- W1998136977 countsByYear W19981369772013 @default.
- W1998136977 countsByYear W19981369772014 @default.
- W1998136977 countsByYear W19981369772015 @default.
- W1998136977 countsByYear W19981369772017 @default.
- W1998136977 countsByYear W19981369772018 @default.
- W1998136977 countsByYear W19981369772019 @default.
- W1998136977 countsByYear W19981369772023 @default.
- W1998136977 crossrefType "journal-article" @default.
- W1998136977 hasAuthorship W1998136977A5048249240 @default.
- W1998136977 hasAuthorship W1998136977A5074151795 @default.
- W1998136977 hasAuthorship W1998136977A5077681133 @default.
- W1998136977 hasAuthorship W1998136977A5090991197 @default.
- W1998136977 hasConcept C185592680 @default.
- W1998136977 hasConcept C203014093 @default.
- W1998136977 hasConcept C2776914184 @default.
- W1998136977 hasConcept C2777063393 @default.
- W1998136977 hasConcept C71924100 @default.
- W1998136977 hasConcept C98274493 @default.
- W1998136977 hasConceptScore W1998136977C185592680 @default.
- W1998136977 hasConceptScore W1998136977C203014093 @default.
- W1998136977 hasConceptScore W1998136977C2776914184 @default.
- W1998136977 hasConceptScore W1998136977C2777063393 @default.
- W1998136977 hasConceptScore W1998136977C71924100 @default.
- W1998136977 hasConceptScore W1998136977C98274493 @default.
- W1998136977 hasIssue "1-2" @default.
- W1998136977 hasLocation W19981369771 @default.
- W1998136977 hasLocation W19981369772 @default.
- W1998136977 hasOpenAccess W1998136977 @default.
- W1998136977 hasPrimaryLocation W19981369771 @default.
- W1998136977 hasRelatedWork W2012620252 @default.
- W1998136977 hasRelatedWork W2018075260 @default.
- W1998136977 hasRelatedWork W2080540649 @default.
- W1998136977 hasRelatedWork W2088472130 @default.
- W1998136977 hasRelatedWork W2101846359 @default.
- W1998136977 hasRelatedWork W2314595703 @default.
- W1998136977 hasRelatedWork W2368412602 @default.
- W1998136977 hasRelatedWork W2411490441 @default.
- W1998136977 hasRelatedWork W2748952813 @default.
- W1998136977 hasRelatedWork W2899084033 @default.
- W1998136977 hasVolume "387" @default.
- W1998136977 isParatext "false" @default.
- W1998136977 isRetracted "false" @default.
- W1998136977 magId "1998136977" @default.
- W1998136977 workType "article" @default.