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- W1998139425 abstract "Mutation of microphthalmia transcription factor (MITF) results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. The primary cell types affected in MITF-deficient mice are melanocytes, osteoclasts and mast cells. A search for MITF-associated proteins, using a mast cell library that was screened with a construct that encodes the basic helix-loop-helix leucine zipper (bHLH-Zip) domain of MITF, resulted in the isolation of the protein kinase C interacting (PKCI) protein 1 and protein inhibitor of activated STAT3 (PIAS3). We have accumulated clear evidence of a function for these two proteins as repressors of MITF-induced transcriptional activity. Here, we describe this evidence and ideas that give some insight into the cellular network of interactions between various transcription factors and MITF." @default.
- W1998139425 created "2016-06-24" @default.
- W1998139425 creator A5002146164 @default.
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- W1998139425 date "2002-09-01" @default.
- W1998139425 modified "2023-10-12" @default.
- W1998139425 title "The function of MITF and associated proteins in mast cells" @default.
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- W1998139425 doi "https://doi.org/10.1016/s0161-5890(02)00059-7" @default.
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