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- W1998152154 abstract "Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix (ECM) and basement membrane (BM) of mammalian tissues. Synthesised attached to various core-proteins to form HS-proteoglycans (HSPG), HS is capable of interacting with various polypeptides and exerting diverse functions. In fact, a bioinformatics analysis of mammalian proteins that express a heparin/HS binding motif and are associated with the immune system identified 235 candidate proteins, the majority having an intracellular location. This simple analysis suggests that HS may, in fact, interact with many more components of the immune system than previously realised. Numerous studies have also directly demonstrated that HS plays multiple prominent functional roles in the immune system that are briefly reviewed in this article. In particular, the molecule has been shown to regulate leukocyte development, leukocyte migration, immune activation and inflammatory processes." @default.
- W1998152154 created "2016-06-24" @default.
- W1998152154 creator A5037798186 @default.
- W1998152154 creator A5068646165 @default.
- W1998152154 date "2013-01-01" @default.
- W1998152154 modified "2023-10-16" @default.
- W1998152154 title "Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity" @default.
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- W1998152154 doi "https://doi.org/10.3389/fimmu.2013.00470" @default.
- W1998152154 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3866581" @default.
- W1998152154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24391644" @default.
- W1998152154 hasPublicationYear "2013" @default.
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