FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998156781> ?p ?o ?g. }

• W1998156781 endingPage "579" @default.
• W1998156781 startingPage "571" @default.
• W1998156781 abstract "Studies in animal models and humans suggest a link between endotoxemia and non-alcoholic steatohepatitis. Since Kupffer cells are responsible for clearing endotoxin and are activated via endotoxin interaction with Toll-like receptor 4 (TLR-4), we examined the relationship between hepatic TLR-4 expression and Kupffer cell content during the genesis of steatohepatitis.Male C57BL/6, C3H/HouJ and TLR-4 mutant C3H/HeJ mice were fed control or methionine/choline-deficient diet (MCDD). In one group of C57BL/6 mice, Kupffer cells were depleted by weekly intraperitoneal injections of clodronate liposomes. After 3 weeks, serum ALT activity and portal endotoxin levels were measured. Real-time PCR was used to examine mRNA expression of TLR-4, TLR-2, CD14, MD-2, TGFbeta, TNFalpha, CD36, PPAR-alpha, liver fatty acid binding protein (L-FABP) and collagen alpha1.We observed histological evidence typical of steatohepatitis, portal endotoxemia and enhanced TLR-4 expression in wild type mice fed MCDD. In contrast, injury and lipid accumulation markers were significantly lower in TLR-4 mutant mice. Destruction of Kupffer cells with clodronate liposomes blunted histological evidence of steatohepatitis and prevented increases in TLR-4 expression.These findings demonstrate the importance of TLR-4 signaling and underscore a direct link between TLR-4 and Kupffer cells in the pathogenesis of steatohepatitis." @default.
• W1998156781 created "2016-06-24" @default.
• W1998156781 creator A5022879200 @default.
• W1998156781 creator A5033958520 @default.
• W1998156781 creator A5046562575 @default.
• W1998156781 creator A5051741096 @default.
• W1998156781 creator A5075398285 @default.
• W1998156781 creator A5079003683 @default.
• W1998156781 date "2007-10-01" @default.
• W1998156781 modified "2023-10-08" @default.
• W1998156781 title "Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis" @default.
• W1998156781 cites W1210607603 @default.
• W1998156781 cites W1505978562 @default.
• W1998156781 cites W1527612695 @default.
• W1998156781 cites W1565820371 @default.
• W1998156781 cites W185724496 @default.
• W1998156781 cites W1902364422 @default.
• W1998156781 cites W1963533730 @default.
• W1998156781 cites W1974863952 @default.
• W1998156781 cites W1986092783 @default.
• W1998156781 cites W1993677761 @default.
• W1998156781 cites W2000223380 @default.
• W1998156781 cites W2008152503 @default.
• W1998156781 cites W2022763702 @default.
• W1998156781 cites W2023632463 @default.
• W1998156781 cites W2026887934 @default.
• W1998156781 cites W2033829190 @default.
• W1998156781 cites W2044591158 @default.
• W1998156781 cites W2054511859 @default.
• W1998156781 cites W2057809738 @default.
• W1998156781 cites W2069663822 @default.
• W1998156781 cites W2080361134 @default.
• W1998156781 cites W2088366586 @default.
• W1998156781 cites W2089264179 @default.
• W1998156781 cites W2103843518 @default.
• W1998156781 cites W2132810971 @default.
• W1998156781 cites W2141158324 @default.
• W1998156781 cites W2142081783 @default.
• W1998156781 cites W2148579227 @default.
• W1998156781 cites W2150679087 @default.
• W1998156781 cites W2153540284 @default.
• W1998156781 cites W2157803722 @default.
• W1998156781 cites W2159555161 @default.
• W1998156781 cites W2167213027 @default.
• W1998156781 cites W2178044610 @default.
• W1998156781 cites W4240210710 @default.
• W1998156781 doi "https://doi.org/10.1016/j.jhep.2007.04.019" @default.
• W1998156781 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2094119" @default.
• W1998156781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17644211" @default.
• W1998156781 hasPublicationYear "2007" @default.
• W1998156781 type Work @default.
• W1998156781 sameAs 1998156781 @default.
• W1998156781 citedByCount "571" @default.
• W1998156781 countsByYear W19981567812012 @default.
• W1998156781 countsByYear W19981567812013 @default.
• W1998156781 countsByYear W19981567812014 @default.
• W1998156781 countsByYear W19981567812015 @default.
• W1998156781 countsByYear W19981567812016 @default.
• W1998156781 countsByYear W19981567812017 @default.
• W1998156781 countsByYear W19981567812018 @default.
• W1998156781 countsByYear W19981567812019 @default.
• W1998156781 countsByYear W19981567812020 @default.
• W1998156781 countsByYear W19981567812021 @default.
• W1998156781 countsByYear W19981567812022 @default.
• W1998156781 countsByYear W19981567812023 @default.
• W1998156781 crossrefType "journal-article" @default.
• W1998156781 hasAuthorship W1998156781A5022879200 @default.
• W1998156781 hasAuthorship W1998156781A5033958520 @default.
• W1998156781 hasAuthorship W1998156781A5046562575 @default.
• W1998156781 hasAuthorship W1998156781A5051741096 @default.
• W1998156781 hasAuthorship W1998156781A5075398285 @default.
• W1998156781 hasAuthorship W1998156781A5079003683 @default.
• W1998156781 hasBestOaLocation W19981567812 @default.
• W1998156781 hasConcept C126322002 @default.
• W1998156781 hasConcept C134018914 @default.
• W1998156781 hasConcept C170493617 @default.
• W1998156781 hasConcept C17991360 @default.
• W1998156781 hasConcept C2778772119 @default.
• W1998156781 hasConcept C2778904781 @default.
• W1998156781 hasConcept C2779134260 @default.
• W1998156781 hasConcept C2779478299 @default.
• W1998156781 hasConcept C2779828298 @default.
• W1998156781 hasConcept C2780942790 @default.
• W1998156781 hasConcept C71924100 @default.
• W1998156781 hasConcept C86803240 @default.
• W1998156781 hasConceptScore W1998156781C126322002 @default.
• W1998156781 hasConceptScore W1998156781C134018914 @default.
• W1998156781 hasConceptScore W1998156781C170493617 @default.
• W1998156781 hasConceptScore W1998156781C17991360 @default.
• W1998156781 hasConceptScore W1998156781C2778772119 @default.
• W1998156781 hasConceptScore W1998156781C2778904781 @default.
• W1998156781 hasConceptScore W1998156781C2779134260 @default.
• W1998156781 hasConceptScore W1998156781C2779478299 @default.
• W1998156781 hasConceptScore W1998156781C2779828298 @default.
• W1998156781 hasConceptScore W1998156781C2780942790 @default.
• W1998156781 hasConceptScore W1998156781C71924100 @default.
• W1998156781 hasConceptScore W1998156781C86803240 @default.
• W1998156781 hasIssue "4" @default.

• next