FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998157605> ?p ?o ?g. }

• W1998157605 endingPage "1046" @default.
• W1998157605 startingPage "1033" @default.
• W1998157605 abstract "KIT receptor is the prime target in gastrointestinal stromal tumor (GISTs) therapy. Second generation inhibitor, Sunitinib, binds to an inactivated conformation of KIT receptor and stabilizes it in order to prevent tumor formation. Here, we investigated the dynamic behavior of wild type and mutant D816H KIT receptor, and emphasized the extended A-loop (EAL) region (805–850) by conducting molecular dynamics simulation (∼100 ns). We analyzed different properties such as root mean square cutoff or deviation, root mean square fluctuation, radius of gyration, solvent-accessible surface area, hydrogen bonding network analysis, and essential dynamics. Apart from this, clustering and cross-correlation matrix approach was used to explore the conformational space of the wild type and mutant EAL region of KIT receptor. Molecular dynamics analysis indicated that mutation (D816H) was able to alter intramolecular hydrogen bonding pattern and affected the structural flexibility of EAL region. Moreover, flexible secondary elements, specially, coil and turns were dominated in EAL region of mutant KIT receptor during simulation. This phenomenon increased the movement of EAL region which in turn helped in shifting the equilibrium towards the active kinase conformation. Our atomic investigation of mutant KIT receptor which emphasized on EAL region provided a better insight into the understanding of Sunitinib resistance mechanism of KIT receptor and would help to discover new therapeutics for KIT-based resistant tumor cells in GIST therapy." @default.
• W1998157605 created "2016-06-24" @default.
• W1998157605 creator A5087385312 @default.
• W1998157605 date "2013-06-20" @default.
• W1998157605 modified "2023-10-03" @default.
• W1998157605 title "Role of ELA region in auto-activation of mutant KIT receptor: a molecular dynamics simulation insight" @default.
• W1998157605 cites W1546148535 @default.
• W1998157605 cites W1858315965 @default.
• W1998157605 cites W1933891757 @default.
• W1998157605 cites W1963496509 @default.
• W1998157605 cites W1964830748 @default.
• W1998157605 cites W1966078827 @default.
• W1998157605 cites W1974582141 @default.
• W1998157605 cites W1975344486 @default.
• W1998157605 cites W1981491302 @default.
• W1998157605 cites W1982550173 @default.
• W1998157605 cites W1985792114 @default.
• W1998157605 cites W1990194768 @default.
• W1998157605 cites W1991175004 @default.
• W1998157605 cites W2009766040 @default.
• W1998157605 cites W2010415450 @default.
• W1998157605 cites W2015267593 @default.
• W1998157605 cites W2019463286 @default.
• W1998157605 cites W2020622784 @default.
• W1998157605 cites W2025299147 @default.
• W1998157605 cites W2029667189 @default.
• W1998157605 cites W2030379493 @default.
• W1998157605 cites W2041415161 @default.
• W1998157605 cites W2046014234 @default.
• W1998157605 cites W2046156589 @default.
• W1998157605 cites W2047544230 @default.
• W1998157605 cites W2053516170 @default.
• W1998157605 cites W2057368673 @default.
• W1998157605 cites W2068926954 @default.
• W1998157605 cites W2075904639 @default.
• W1998157605 cites W2087431066 @default.
• W1998157605 cites W2101214437 @default.
• W1998157605 cites W2103945336 @default.
• W1998157605 cites W2116978122 @default.
• W1998157605 cites W2128572087 @default.
• W1998157605 cites W2132589721 @default.
• W1998157605 cites W2143295396 @default.
• W1998157605 cites W2144081223 @default.
• W1998157605 cites W2161599196 @default.
• W1998157605 cites W2164559539 @default.
• W1998157605 cites W2165779834 @default.
• W1998157605 cites W2166208462 @default.
• W1998157605 cites W2171268876 @default.
• W1998157605 cites W4249638410 @default.
• W1998157605 doi "https://doi.org/10.1080/07391102.2013.803264" @default.
• W1998157605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23782055" @default.
• W1998157605 hasPublicationYear "2013" @default.
• W1998157605 type Work @default.
• W1998157605 sameAs 1998157605 @default.
• W1998157605 citedByCount "96" @default.
• W1998157605 countsByYear W19981576052013 @default.
• W1998157605 countsByYear W19981576052014 @default.
• W1998157605 countsByYear W19981576052015 @default.
• W1998157605 countsByYear W19981576052016 @default.
• W1998157605 countsByYear W19981576052017 @default.
• W1998157605 countsByYear W19981576052018 @default.
• W1998157605 countsByYear W19981576052019 @default.
• W1998157605 countsByYear W19981576052020 @default.
• W1998157605 countsByYear W19981576052021 @default.
• W1998157605 countsByYear W19981576052022 @default.
• W1998157605 countsByYear W19981576052023 @default.
• W1998157605 crossrefType "journal-article" @default.
• W1998157605 hasAuthorship W1998157605A5087385312 @default.
• W1998157605 hasBestOaLocation W19981576052 @default.
• W1998157605 hasConcept C104317684 @default.
• W1998157605 hasConcept C112887158 @default.
• W1998157605 hasConcept C12554922 @default.
• W1998157605 hasConcept C143065580 @default.
• W1998157605 hasConcept C147597530 @default.
• W1998157605 hasConcept C170493617 @default.
• W1998157605 hasConcept C178790620 @default.
• W1998157605 hasConcept C185592680 @default.
• W1998157605 hasConcept C32909587 @default.
• W1998157605 hasConcept C55493867 @default.
• W1998157605 hasConcept C59593255 @default.
• W1998157605 hasConcept C86803240 @default.
• W1998157605 hasConceptScore W1998157605C104317684 @default.
• W1998157605 hasConceptScore W1998157605C112887158 @default.
• W1998157605 hasConceptScore W1998157605C12554922 @default.
• W1998157605 hasConceptScore W1998157605C143065580 @default.
• W1998157605 hasConceptScore W1998157605C147597530 @default.
• W1998157605 hasConceptScore W1998157605C170493617 @default.
• W1998157605 hasConceptScore W1998157605C178790620 @default.
• W1998157605 hasConceptScore W1998157605C185592680 @default.
• W1998157605 hasConceptScore W1998157605C32909587 @default.
• W1998157605 hasConceptScore W1998157605C55493867 @default.
• W1998157605 hasConceptScore W1998157605C59593255 @default.
• W1998157605 hasConceptScore W1998157605C86803240 @default.
• W1998157605 hasIssue "7" @default.
• W1998157605 hasLocation W19981576051 @default.
• W1998157605 hasLocation W19981576052 @default.
• W1998157605 hasLocation W19981576053 @default.
• W1998157605 hasOpenAccess W1998157605 @default.

• next