FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998163397> ?p ?o ?g. }

• W1998163397 endingPage "1558" @default.
• W1998163397 startingPage "1553" @default.
• W1998163397 abstract "Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We compared the expression of Egr-1 during B cell stimulation with Fab'2 and IgG anti-immunoglobulin (anti-Ig), since it is known that Fab'2 anti-Ig is mitogenic while IgG anti-Ig is not, owing to a dominant inhibitory effect of crosslinking the B cell Fc gamma RII to membrane Ig. While mitogenic doses of Fab'2 anti-Ig induce large and rapid increases in Egr-1 expression, IgG anti-Ig results in smaller increases in Egr-1 mRNA, comparable to that seen with submitogenic concentrations of Fab'2 anti-Ig. However, the correlation between Egr-1 expression and B cell proliferation breaks down when IL-4 is added as a co-mitogen to induce B cell proliferation with IgG anti-Ig or submitogenic concentrations of Fab'2 anti-Ig. No corresponding increases in Egr-1 mRNA levels are observed when IL-4 is added. Therefore, IL-4 overcomes Fc receptor-mediated inhibition of B cell proliferation without affecting inhibition of Egr-1 mRNA induction, as demonstrated earlier for c-myc mRNA in this system." @default.
• W1998163397 created "2016-06-24" @default.
• W1998163397 creator A5000277715 @default.
• W1998163397 creator A5027372449 @default.
• W1998163397 creator A5057318981 @default.
• W1998163397 date "1993-11-01" @default.
• W1998163397 modified "2023-10-03" @default.
• W1998163397 title "Effects of IL-4 and Fcγ receptor II engagement on Egr-1 expression during stimulation of B lymphocytes by membrane immunoglobulin crosslinking" @default.
• W1998163397 cites W1505460088 @default.
• W1998163397 cites W1919000175 @default.
• W1998163397 cites W1969397001 @default.
• W1998163397 cites W1975020660 @default.
• W1998163397 cites W1984767179 @default.
• W1998163397 cites W2001248550 @default.
• W1998163397 cites W2008295169 @default.
• W1998163397 cites W2031407459 @default.
• W1998163397 cites W2037244730 @default.
• W1998163397 cites W2041349963 @default.
• W1998163397 cites W2043791855 @default.
• W1998163397 cites W2045416877 @default.
• W1998163397 cites W2054279863 @default.
• W1998163397 cites W2054923140 @default.
• W1998163397 cites W2122999278 @default.
• W1998163397 cites W2134828784 @default.
• W1998163397 cites W2134897499 @default.
• W1998163397 cites W2139613570 @default.
• W1998163397 cites W2144263195 @default.
• W1998163397 cites W2148534815 @default.
• W1998163397 cites W2167604659 @default.
• W1998163397 cites W2167921759 @default.
• W1998163397 cites W2324275051 @default.
• W1998163397 doi "https://doi.org/10.1016/0161-5890(93)90463-l" @default.
• W1998163397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8232340" @default.
• W1998163397 hasPublicationYear "1993" @default.
• W1998163397 type Work @default.
• W1998163397 sameAs 1998163397 @default.
• W1998163397 citedByCount "4" @default.
• W1998163397 countsByYear W19981633972015 @default.
• W1998163397 crossrefType "journal-article" @default.
• W1998163397 hasAuthorship W1998163397A5000277715 @default.
• W1998163397 hasAuthorship W1998163397A5027372449 @default.
• W1998163397 hasAuthorship W1998163397A5057318981 @default.
• W1998163397 hasConcept C104317684 @default.
• W1998163397 hasConcept C105580179 @default.
• W1998163397 hasConcept C127561419 @default.
• W1998163397 hasConcept C134018914 @default.
• W1998163397 hasConcept C1491633281 @default.
• W1998163397 hasConcept C153911025 @default.
• W1998163397 hasConcept C157695867 @default.
• W1998163397 hasConcept C159654299 @default.
• W1998163397 hasConcept C170493617 @default.
• W1998163397 hasConcept C185592680 @default.
• W1998163397 hasConcept C197462201 @default.
• W1998163397 hasConcept C203014093 @default.
• W1998163397 hasConcept C24998067 @default.
• W1998163397 hasConcept C2778453870 @default.
• W1998163397 hasConcept C2780898057 @default.
• W1998163397 hasConcept C2909900342 @default.
• W1998163397 hasConcept C55493867 @default.
• W1998163397 hasConcept C62112901 @default.
• W1998163397 hasConcept C86803240 @default.
• W1998163397 hasConceptScore W1998163397C104317684 @default.
• W1998163397 hasConceptScore W1998163397C105580179 @default.
• W1998163397 hasConceptScore W1998163397C127561419 @default.
• W1998163397 hasConceptScore W1998163397C134018914 @default.
• W1998163397 hasConceptScore W1998163397C1491633281 @default.
• W1998163397 hasConceptScore W1998163397C153911025 @default.
• W1998163397 hasConceptScore W1998163397C157695867 @default.
• W1998163397 hasConceptScore W1998163397C159654299 @default.
• W1998163397 hasConceptScore W1998163397C170493617 @default.
• W1998163397 hasConceptScore W1998163397C185592680 @default.
• W1998163397 hasConceptScore W1998163397C197462201 @default.
• W1998163397 hasConceptScore W1998163397C203014093 @default.
• W1998163397 hasConceptScore W1998163397C24998067 @default.
• W1998163397 hasConceptScore W1998163397C2778453870 @default.
• W1998163397 hasConceptScore W1998163397C2780898057 @default.
• W1998163397 hasConceptScore W1998163397C2909900342 @default.
• W1998163397 hasConceptScore W1998163397C55493867 @default.
• W1998163397 hasConceptScore W1998163397C62112901 @default.
• W1998163397 hasConceptScore W1998163397C86803240 @default.
• W1998163397 hasIssue "16" @default.
• W1998163397 hasLocation W19981633971 @default.
• W1998163397 hasLocation W19981633972 @default.
• W1998163397 hasOpenAccess W1998163397 @default.
• W1998163397 hasPrimaryLocation W19981633971 @default.
• W1998163397 hasRelatedWork W1489034315 @default.
• W1998163397 hasRelatedWork W1998163397 @default.
• W1998163397 hasRelatedWork W2023162116 @default.
• W1998163397 hasRelatedWork W2042656724 @default.
• W1998163397 hasRelatedWork W2045416877 @default.
• W1998163397 hasRelatedWork W2088026744 @default.
• W1998163397 hasRelatedWork W2412525097 @default.
• W1998163397 hasRelatedWork W2464013109 @default.
• W1998163397 hasRelatedWork W2967565826 @default.
• W1998163397 hasRelatedWork W4232284067 @default.
• W1998163397 hasVolume "30" @default.
• W1998163397 isParatext "false" @default.
• W1998163397 isRetracted "false" @default.

• next