FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998172016> ?p ?o ?g. }

• W1998172016 endingPage "e43616" @default.
• W1998172016 startingPage "e43616" @default.
• W1998172016 abstract "Objective Mesenchymal progenitor cells (MPCs) can differentiate into osteoblasts, adipocytes, and chondrocytes, and are in part responsible for maintaining tissue integrity. Recently, a progenitor cell population has been found within the synovial fluid that shares many similarities with bone marrow MPCs. These synovial fluid MPCs (sfMPCs) share the ability to differentiate into bone and fat, with a bias for cartilage differentiation. In this study, sfMPCs were isolated from human and canine synovial fluid collected from normal individuals and those with osteoarthritis (human: clinician-diagnosed, canine: experimental) to compare the differentiation potential of CD90+ vs. CD90− sfMPCs, and to determine if CD90 (Thy-1) is a predictive marker of synovial fluid progenitors with chondrogenic capacity in vitro. Methods sfMPCs were derived from synovial fluid from normal and OA knee joints. These cells were induced to differentiate into chondrocytes and analyzed using quantitative PCR, immunofluorescence, and electron microscopy. Results The CD90+ subpopulation of sfMPCs had increased chondrogenic potential compared to the CD90− population. Furthermore, sfMPCs derived from healthy joints did not require a micro-mass step for efficient chondrogenesis. Whereas sfMPCs from OA synovial fluid retain the ability to undergo chondrogenic differentiation, they require micro-mass culture conditions. Conclusions Overall, this study has demonstrated an increased chondrogenic potential within the CD90+ fraction of human and canine sfMPCs and that this population of cells derived from healthy normal joints do not require a micro-mass step for efficient chondrogenesis, while sfMPCs obtained from OA knee joints do not differentiate efficiently into chondrocytes without the micro-mass procedure. These results reveal a fundamental shift in the chondrogenic ability of cells isolated from arthritic joint fluids, and we speculate that the mechanism behind this change of cell behavior is exposure to the altered milieu of the OA joint fluid, which will be examined in further studies." @default.
• W1998172016 created "2016-06-24" @default.
• W1998172016 creator A5041835261 @default.
• W1998172016 creator A5061396807 @default.
• W1998172016 creator A5066506161 @default.
• W1998172016 creator A5077397108 @default.
• W1998172016 creator A5084465267 @default.
• W1998172016 creator A5088763053 @default.
• W1998172016 date "2012-08-29" @default.
• W1998172016 modified "2023-09-23" @default.
• W1998172016 title "Synovial Fluid Progenitors Expressing CD90+ from Normal but Not Osteoarthritic Joints Undergo Chondrogenic Differentiation without Micro-Mass Culture" @default.
• W1998172016 cites W124350502 @default.
• W1998172016 cites W1965380417 @default.
• W1998172016 cites W1979395943 @default.
• W1998172016 cites W1983400445 @default.
• W1998172016 cites W1985142436 @default.
• W1998172016 cites W1988188434 @default.
• W1998172016 cites W1991415492 @default.
• W1998172016 cites W1998331586 @default.
• W1998172016 cites W1999676511 @default.
• W1998172016 cites W2001960993 @default.
• W1998172016 cites W2010208834 @default.
• W1998172016 cites W2014107261 @default.
• W1998172016 cites W2018648995 @default.
• W1998172016 cites W2025371271 @default.
• W1998172016 cites W2027145435 @default.
• W1998172016 cites W2028524664 @default.
• W1998172016 cites W2033010091 @default.
• W1998172016 cites W2042741613 @default.
• W1998172016 cites W2049521062 @default.
• W1998172016 cites W2058147305 @default.
• W1998172016 cites W2069534290 @default.
• W1998172016 cites W2081655794 @default.
• W1998172016 cites W2096388167 @default.
• W1998172016 cites W2100562749 @default.
• W1998172016 cites W2104391960 @default.
• W1998172016 cites W2107190603 @default.
• W1998172016 cites W2110042978 @default.
• W1998172016 cites W2110114833 @default.
• W1998172016 cites W2110319612 @default.
• W1998172016 cites W2111121117 @default.
• W1998172016 cites W2116636771 @default.
• W1998172016 cites W2124862322 @default.
• W1998172016 cites W2159999899 @default.
• W1998172016 cites W2162800253 @default.
• W1998172016 cites W2162851064 @default.
• W1998172016 doi "https://doi.org/10.1371/journal.pone.0043616" @default.
• W1998172016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3440315" @default.
• W1998172016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952721" @default.
• W1998172016 hasPublicationYear "2012" @default.
• W1998172016 type Work @default.
• W1998172016 sameAs 1998172016 @default.
• W1998172016 citedByCount "48" @default.
• W1998172016 countsByYear W19981720162012 @default.
• W1998172016 countsByYear W19981720162013 @default.
• W1998172016 countsByYear W19981720162014 @default.
• W1998172016 countsByYear W19981720162015 @default.
• W1998172016 countsByYear W19981720162016 @default.
• W1998172016 countsByYear W19981720162017 @default.
• W1998172016 countsByYear W19981720162018 @default.
• W1998172016 countsByYear W19981720162019 @default.
• W1998172016 countsByYear W19981720162020 @default.
• W1998172016 countsByYear W19981720162021 @default.
• W1998172016 countsByYear W19981720162022 @default.
• W1998172016 countsByYear W19981720162023 @default.
• W1998172016 crossrefType "journal-article" @default.
• W1998172016 hasAuthorship W1998172016A5041835261 @default.
• W1998172016 hasAuthorship W1998172016A5061396807 @default.
• W1998172016 hasAuthorship W1998172016A5066506161 @default.
• W1998172016 hasAuthorship W1998172016A5077397108 @default.
• W1998172016 hasAuthorship W1998172016A5084465267 @default.
• W1998172016 hasAuthorship W1998172016A5088763053 @default.
• W1998172016 hasBestOaLocation W19981720161 @default.
• W1998172016 hasConcept C10205521 @default.
• W1998172016 hasConcept C105702510 @default.
• W1998172016 hasConcept C116716535 @default.
• W1998172016 hasConcept C142724271 @default.
• W1998172016 hasConcept C185592680 @default.
• W1998172016 hasConcept C198826908 @default.
• W1998172016 hasConcept C201750760 @default.
• W1998172016 hasConcept C204787440 @default.
• W1998172016 hasConcept C2776164576 @default.
• W1998172016 hasConcept C2776268809 @default.
• W1998172016 hasConcept C2779663596 @default.
• W1998172016 hasConcept C2780550940 @default.
• W1998172016 hasConcept C28328180 @default.
• W1998172016 hasConcept C2908647359 @default.
• W1998172016 hasConcept C3020332539 @default.
• W1998172016 hasConcept C35496256 @default.
• W1998172016 hasConcept C71924100 @default.
• W1998172016 hasConcept C86803240 @default.
• W1998172016 hasConcept C95444343 @default.
• W1998172016 hasConcept C99454951 @default.
• W1998172016 hasConceptScore W1998172016C10205521 @default.
• W1998172016 hasConceptScore W1998172016C105702510 @default.
• W1998172016 hasConceptScore W1998172016C116716535 @default.
• W1998172016 hasConceptScore W1998172016C142724271 @default.
• W1998172016 hasConceptScore W1998172016C185592680 @default.

• next