Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998174575> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1998174575 endingPage "474" @default.
- W1998174575 startingPage "465" @default.
- W1998174575 abstract "The long-term pulmonary morphologic and biochemical changes induced by a single, sublethal dose of O,O,S-trimethyl phosphorothioate (OOS-TMP), an impurity present in organophosphorus insecticides, was examined in female WAG/Rij rats. Animals received either corn oil or a corn oil solution of OOS-TMP at a dose of 40 mg/kg body weight by gavage and were studied at the following time intervals after treatment: 10 days, 90 days, 6 months, and 1 year. No control or OOS-TMP-treated animal died spontaneously. Significant increases in wet and dry lung weights occurred at all times examined in OOS-TMP-treated rats compared to those in age-matched controls. No difference was observed in percentage lung water content between treated and control rats. OOS-TMP treatment resulted in hypertrophy and hyperplasia of type II alveolar epithelial cells having morphologic alterations in the size and number of osmiophilic lamellar bodies. Interstitial changes were characterized as increased numbers of fibroblasts accompanied by increased amounts of collagen fibrils and basement membrane alterations. There was also a significant increase in pulmonary hydroxyproline content in OOS-TMP-treated animals compared to that in controls at all time periods. Collagen deposition was predominantly associated with the interalveolar septa rather than being oriented around airways. The results of this study indicate that a single, sublethal dose of OOS-TMP induces long-term structural and biochemical changes in the rat lung." @default.
- W1998174575 created "2016-06-24" @default.
- W1998174575 creator A5020668415 @default.
- W1998174575 creator A5034287604 @default.
- W1998174575 date "1989-05-01" @default.
- W1998174575 modified "2023-09-24" @default.
- W1998174575 title "Long-term morphologic and biochemical changes induced by O,O,S-trimethyl phosphorothioate in the rat lung" @default.
- W1998174575 cites W1209348739 @default.
- W1998174575 cites W1513425511 @default.
- W1998174575 cites W1577700058 @default.
- W1998174575 cites W1954428203 @default.
- W1998174575 cites W1957734831 @default.
- W1998174575 cites W1966178798 @default.
- W1998174575 cites W1976018371 @default.
- W1998174575 cites W1976236115 @default.
- W1998174575 cites W1976588996 @default.
- W1998174575 cites W1993976512 @default.
- W1998174575 cites W2004427074 @default.
- W1998174575 cites W2011321125 @default.
- W1998174575 cites W2012037676 @default.
- W1998174575 cites W2020613737 @default.
- W1998174575 cites W2068589168 @default.
- W1998174575 cites W2083457869 @default.
- W1998174575 cites W2090005133 @default.
- W1998174575 cites W2094209930 @default.
- W1998174575 cites W2297690703 @default.
- W1998174575 cites W2335757080 @default.
- W1998174575 cites W2340094078 @default.
- W1998174575 cites W2395796727 @default.
- W1998174575 cites W2413831166 @default.
- W1998174575 cites W2414458067 @default.
- W1998174575 cites W2417055726 @default.
- W1998174575 cites W2430336341 @default.
- W1998174575 cites W2443086794 @default.
- W1998174575 cites W2462530877 @default.
- W1998174575 cites W2468996246 @default.
- W1998174575 cites W2408352946 @default.
- W1998174575 doi "https://doi.org/10.1016/0041-008x(89)90175-0" @default.
- W1998174575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2718175" @default.
- W1998174575 hasPublicationYear "1989" @default.
- W1998174575 type Work @default.
- W1998174575 sameAs 1998174575 @default.
- W1998174575 citedByCount "3" @default.
- W1998174575 crossrefType "journal-article" @default.
- W1998174575 hasAuthorship W1998174575A5020668415 @default.
- W1998174575 hasAuthorship W1998174575A5034287604 @default.
- W1998174575 hasConcept C126322002 @default.
- W1998174575 hasConcept C134018914 @default.
- W1998174575 hasConcept C140793950 @default.
- W1998174575 hasConcept C16685009 @default.
- W1998174575 hasConcept C167414201 @default.
- W1998174575 hasConcept C185592680 @default.
- W1998174575 hasConcept C2777562237 @default.
- W1998174575 hasConcept C2777714996 @default.
- W1998174575 hasConcept C2778206080 @default.
- W1998174575 hasConcept C2779797417 @default.
- W1998174575 hasConcept C71924100 @default.
- W1998174575 hasConcept C86803240 @default.
- W1998174575 hasConceptScore W1998174575C126322002 @default.
- W1998174575 hasConceptScore W1998174575C134018914 @default.
- W1998174575 hasConceptScore W1998174575C140793950 @default.
- W1998174575 hasConceptScore W1998174575C16685009 @default.
- W1998174575 hasConceptScore W1998174575C167414201 @default.
- W1998174575 hasConceptScore W1998174575C185592680 @default.
- W1998174575 hasConceptScore W1998174575C2777562237 @default.
- W1998174575 hasConceptScore W1998174575C2777714996 @default.
- W1998174575 hasConceptScore W1998174575C2778206080 @default.
- W1998174575 hasConceptScore W1998174575C2779797417 @default.
- W1998174575 hasConceptScore W1998174575C71924100 @default.
- W1998174575 hasConceptScore W1998174575C86803240 @default.
- W1998174575 hasIssue "3" @default.
- W1998174575 hasLocation W19981745751 @default.
- W1998174575 hasLocation W19981745752 @default.
- W1998174575 hasOpenAccess W1998174575 @default.
- W1998174575 hasPrimaryLocation W19981745751 @default.
- W1998174575 hasRelatedWork W1779480512 @default.
- W1998174575 hasRelatedWork W1970861121 @default.
- W1998174575 hasRelatedWork W1986049049 @default.
- W1998174575 hasRelatedWork W1993774701 @default.
- W1998174575 hasRelatedWork W1998174575 @default.
- W1998174575 hasRelatedWork W2002616541 @default.
- W1998174575 hasRelatedWork W2021603989 @default.
- W1998174575 hasRelatedWork W2049047086 @default.
- W1998174575 hasRelatedWork W2081636567 @default.
- W1998174575 hasRelatedWork W2091504832 @default.
- W1998174575 hasVolume "98" @default.
- W1998174575 isParatext "false" @default.
- W1998174575 isRetracted "false" @default.
- W1998174575 magId "1998174575" @default.
- W1998174575 workType "article" @default.