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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998176466> ?p ?o ?g. }

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• W1998176466 abstract "Conformationally-constrained macrocyclic peptide-based hydroxyethylamines, with 17- to 19-membered ring systems, have been designed and synthesized as HIV protease inhibitors. Structure-activity relationships were consistent with molecular modeling studies, and certain cyclic inhibitors were developed with HIV protease IC50 values of ∼1 nM, and antiviral activities (HIV-1/RF infected MT-2 cells) of EC50 4–8 nM." @default.
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• W1998176466 date "1994-09-01" @default.
• W1998176466 modified "2023-09-27" @default.
• W1998176466 title "Design, synthesis, and activity of conformationally-constrained macrocyclic peptide-based inhibitors of HIV protease" @default.
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• W1998176466 doi "https://doi.org/10.1016/s0960-894x(00)80074-8" @default.
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