Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998182500> ?p ?o ?g. }
- W1998182500 endingPage "1493" @default.
- W1998182500 startingPage "1481" @default.
- W1998182500 abstract "The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized (Cx) rats were greater than in age-matched control rats, sham Cx (Sx). The increase in thymic cellularity reflected an increase in thymocyte proliferation rate (the proportion of proliferating cells was 18.6 ± 0.7% in 2-month-old Cx (N = 5) vs 13.4 ± 0.3% (N = 5) in age-matched Sx rats) followed by reduced sensitivity to apoptotic signals (apoptotic thymocytes were 9.8 ± 0.9% in 2-month-old Cx (N = 5) vs 15.5 ± 0.3% (N = 5) age-matched Sx rats). However, 9 months post-orchidectomy, neither thymic weight and cellularity nor any of the morphometric parameters analyzed differed between Cx and control rats. The reduction of thymic cellularity in Cx rats to control values may be related to increased sensitivity of their thymocytes to apoptotic signals in culture (72.6 ± 1.2% in 10-month-old vs 9.8 ± 0.9% in 2-month-old Cx rats) followed by reduced responsiveness to proliferative stimuli (14.1 ± 0.2% in 10-month-old vs 18.6 ± 0.7% in 2-month-old Cx rats). Thus, the study indicates that the effects of peripubertal orchidectomy on thymic weight and cellularity, as well as on the main morphometric indices, are long-lasting but not permanent, i.e., that removal of the testes can only postpone but not prevent age-related organ atrophy and consequently functional deterioration of the immune system." @default.
- W1998182500 created "2016-06-24" @default.
- W1998182500 creator A5009494657 @default.
- W1998182500 creator A5017105469 @default.
- W1998182500 creator A5031055396 @default.
- W1998182500 creator A5032824902 @default.
- W1998182500 creator A5056521919 @default.
- W1998182500 creator A5077388695 @default.
- W1998182500 creator A5088641765 @default.
- W1998182500 date "2007-11-01" @default.
- W1998182500 modified "2023-10-16" @default.
- W1998182500 title "Peripubertal orchidectomy transitorily affects age-associated thymic involution in rats" @default.
- W1998182500 cites W1873458020 @default.
- W1998182500 cites W1925402793 @default.
- W1998182500 cites W1961087288 @default.
- W1998182500 cites W1964441939 @default.
- W1998182500 cites W1965220351 @default.
- W1998182500 cites W1970414548 @default.
- W1998182500 cites W1972394760 @default.
- W1998182500 cites W1973888479 @default.
- W1998182500 cites W1974346743 @default.
- W1998182500 cites W1984876328 @default.
- W1998182500 cites W1993057390 @default.
- W1998182500 cites W1995239001 @default.
- W1998182500 cites W1997122481 @default.
- W1998182500 cites W2003819161 @default.
- W1998182500 cites W2009432885 @default.
- W1998182500 cites W2014148414 @default.
- W1998182500 cites W2023544860 @default.
- W1998182500 cites W2026990654 @default.
- W1998182500 cites W2028694464 @default.
- W1998182500 cites W2040564355 @default.
- W1998182500 cites W2041880296 @default.
- W1998182500 cites W2064602503 @default.
- W1998182500 cites W2065655790 @default.
- W1998182500 cites W2068408311 @default.
- W1998182500 cites W2069616014 @default.
- W1998182500 cites W2070711285 @default.
- W1998182500 cites W2075466256 @default.
- W1998182500 cites W2075872822 @default.
- W1998182500 cites W2086454249 @default.
- W1998182500 cites W2087004730 @default.
- W1998182500 cites W2088561119 @default.
- W1998182500 cites W2089091427 @default.
- W1998182500 cites W2091065606 @default.
- W1998182500 cites W2093627166 @default.
- W1998182500 cites W2096584806 @default.
- W1998182500 cites W2104259190 @default.
- W1998182500 cites W2104962128 @default.
- W1998182500 cites W2129823364 @default.
- W1998182500 cites W2333326912 @default.
- W1998182500 cites W2396350103 @default.
- W1998182500 doi "https://doi.org/10.1590/s0100-879x2007001100009" @default.
- W1998182500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17934645" @default.
- W1998182500 hasPublicationYear "2007" @default.
- W1998182500 type Work @default.
- W1998182500 sameAs 1998182500 @default.
- W1998182500 citedByCount "6" @default.
- W1998182500 countsByYear W19981825002014 @default.
- W1998182500 countsByYear W19981825002015 @default.
- W1998182500 countsByYear W19981825002019 @default.
- W1998182500 crossrefType "journal-article" @default.
- W1998182500 hasAuthorship W1998182500A5009494657 @default.
- W1998182500 hasAuthorship W1998182500A5017105469 @default.
- W1998182500 hasAuthorship W1998182500A5031055396 @default.
- W1998182500 hasAuthorship W1998182500A5032824902 @default.
- W1998182500 hasAuthorship W1998182500A5056521919 @default.
- W1998182500 hasAuthorship W1998182500A5077388695 @default.
- W1998182500 hasAuthorship W1998182500A5088641765 @default.
- W1998182500 hasBestOaLocation W19981825001 @default.
- W1998182500 hasConcept C126322002 @default.
- W1998182500 hasConcept C134018914 @default.
- W1998182500 hasConcept C169760540 @default.
- W1998182500 hasConcept C186720457 @default.
- W1998182500 hasConcept C190283241 @default.
- W1998182500 hasConcept C203014093 @default.
- W1998182500 hasConcept C2776090121 @default.
- W1998182500 hasConcept C2777314012 @default.
- W1998182500 hasConcept C2778954852 @default.
- W1998182500 hasConcept C2779256933 @default.
- W1998182500 hasConcept C2781409172 @default.
- W1998182500 hasConcept C55493867 @default.
- W1998182500 hasConcept C71315377 @default.
- W1998182500 hasConcept C71924100 @default.
- W1998182500 hasConcept C86803240 @default.
- W1998182500 hasConcept C8891405 @default.
- W1998182500 hasConceptScore W1998182500C126322002 @default.
- W1998182500 hasConceptScore W1998182500C134018914 @default.
- W1998182500 hasConceptScore W1998182500C169760540 @default.
- W1998182500 hasConceptScore W1998182500C186720457 @default.
- W1998182500 hasConceptScore W1998182500C190283241 @default.
- W1998182500 hasConceptScore W1998182500C203014093 @default.
- W1998182500 hasConceptScore W1998182500C2776090121 @default.
- W1998182500 hasConceptScore W1998182500C2777314012 @default.
- W1998182500 hasConceptScore W1998182500C2778954852 @default.
- W1998182500 hasConceptScore W1998182500C2779256933 @default.
- W1998182500 hasConceptScore W1998182500C2781409172 @default.
- W1998182500 hasConceptScore W1998182500C55493867 @default.