FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998182907> ?p ?o ?g. }

• W1998182907 endingPage "48814" @default.
• W1998182907 startingPage "48804" @default.
• W1998182907 abstract "The pH-related characteristics of 4-thiothymidine and its stability during prolonged exposure, at room temperature, to a neon lamp emitting in the 400–700 nm wavelength range were investigated by different spectroscopic techniques (UV-Vis, FTIR-ATR, 1H-NMR) and by ElectroSpray Ionization Mass Spectrometry (ESI-MS). The evaluation of the nucleoside photostability was performed as a control, with the perspective of studying its reactivity under the same conditions but in the presence of visible light-absorbing photosensitizers, able to generate reactive oxygen species. The comparison between UV-Vis spectra recorded at different pH values in the 7–12 range suggested the presence of an equilibrium related to the deprotonation of the N3–H group of 4-thiothymidine, with a pKa estimated to be close to 9. Some effects of the deprotonation occurring at alkaline pH were observed also in FTIR-ATR spectra, the main feature being the appearance of a band related to CN stretching, interpreted with the assumption of a partial double bond character by C2–N3, N3–C4 and C2–O− bonds, as a consequence of negative charge delocalization on the pyrimidine ring. As for photostability, UV-Vis, FTIR-ATR and NMR measurements suggested the generation of thymidine as a by-product but only after a prolonged (48 hours) irradiation time, whereas no significant alteration occurred in a shorter time range (1–2 hours), i.e. the one that will be considered in future studies involving the presence of photosensitizers. The nucleoside stability up to 2 hours of irradiation was confirmed by ESI-MS analyses; furthermore, on the other hand, the latter indicated the presence of three additional by-products, besides thymidine, after 48 hours of irradiation. In particular, an hydroxylated form of 4-thiothymidine and two dimeric species, characterized by S–S and S–O covalent bridges between two 4-thiothymidine and a 4-thiothymidine and a thymidine molecule, respectively, were detected." @default.
• W1998182907 created "2016-06-24" @default.
• W1998182907 creator A5011624291 @default.
• W1998182907 creator A5011820128 @default.
• W1998182907 creator A5025146379 @default.
• W1998182907 creator A5032276101 @default.
• W1998182907 creator A5046064764 @default.
• W1998182907 creator A5063801863 @default.
• W1998182907 creator A5066417679 @default.
• W1998182907 date "2014-09-15" @default.
• W1998182907 modified "2023-10-01" @default.
• W1998182907 title "pH-related features and photostability of 4-thiothymidine in aqueous solution: an investigation by UV-visible, NMR and FTIR-ATR spectroscopies and by electrospray ionization mass spectrometry" @default.
• W1998182907 cites W110323785 @default.
• W1998182907 cites W1490565462 @default.
• W1998182907 cites W1534689561 @default.
• W1998182907 cites W1596051841 @default.
• W1998182907 cites W1820120239 @default.
• W1998182907 cites W1917830048 @default.
• W1998182907 cites W1920145026 @default.
• W1998182907 cites W1965880766 @default.
• W1998182907 cites W1979270129 @default.
• W1998182907 cites W1980697130 @default.
• W1998182907 cites W1981348886 @default.
• W1998182907 cites W1986186363 @default.
• W1998182907 cites W1987197853 @default.
• W1998182907 cites W1999081294 @default.
• W1998182907 cites W2005302728 @default.
• W1998182907 cites W2006623142 @default.
• W1998182907 cites W2013408101 @default.
• W1998182907 cites W2018634944 @default.
• W1998182907 cites W2020640998 @default.
• W1998182907 cites W2022093849 @default.
• W1998182907 cites W2026789913 @default.
• W1998182907 cites W2031993007 @default.
• W1998182907 cites W2037770545 @default.
• W1998182907 cites W2041293640 @default.
• W1998182907 cites W2041736611 @default.
• W1998182907 cites W2042931953 @default.
• W1998182907 cites W2043643111 @default.
• W1998182907 cites W2049525659 @default.
• W1998182907 cites W2053099555 @default.
• W1998182907 cites W2060809789 @default.
• W1998182907 cites W2061928454 @default.
• W1998182907 cites W2063870969 @default.
• W1998182907 cites W2069636180 @default.
• W1998182907 cites W2070444591 @default.
• W1998182907 cites W2071338286 @default.
• W1998182907 cites W2072509880 @default.
• W1998182907 cites W2072541805 @default.
• W1998182907 cites W2073500401 @default.
• W1998182907 cites W2083544305 @default.
• W1998182907 cites W2087917300 @default.
• W1998182907 cites W2090643890 @default.
• W1998182907 cites W2104094507 @default.
• W1998182907 cites W2127245713 @default.
• W1998182907 cites W2140018962 @default.
• W1998182907 cites W2158815442 @default.
• W1998182907 cites W2202708258 @default.
• W1998182907 cites W287296146 @default.
• W1998182907 cites W2949952620 @default.
• W1998182907 doi "https://doi.org/10.1039/c4ra09747e" @default.
• W1998182907 hasPublicationYear "2014" @default.
• W1998182907 type Work @default.
• W1998182907 sameAs 1998182907 @default.
• W1998182907 citedByCount "14" @default.
• W1998182907 countsByYear W19981829072015 @default.
• W1998182907 countsByYear W19981829072016 @default.
• W1998182907 countsByYear W19981829072018 @default.
• W1998182907 countsByYear W19981829072019 @default.
• W1998182907 countsByYear W19981829072021 @default.
• W1998182907 countsByYear W19981829072022 @default.
• W1998182907 countsByYear W19981829072023 @default.
• W1998182907 crossrefType "journal-article" @default.
• W1998182907 hasAuthorship W1998182907A5011624291 @default.
• W1998182907 hasAuthorship W1998182907A5011820128 @default.
• W1998182907 hasAuthorship W1998182907A5025146379 @default.
• W1998182907 hasAuthorship W1998182907A5032276101 @default.
• W1998182907 hasAuthorship W1998182907A5046064764 @default.
• W1998182907 hasAuthorship W1998182907A5063801863 @default.
• W1998182907 hasAuthorship W1998182907A5066417679 @default.
• W1998182907 hasConcept C103319777 @default.
• W1998182907 hasConcept C113196181 @default.
• W1998182907 hasConcept C118629725 @default.
• W1998182907 hasConcept C121332964 @default.
• W1998182907 hasConcept C13965031 @default.
• W1998182907 hasConcept C142724271 @default.
• W1998182907 hasConcept C145148216 @default.
• W1998182907 hasConcept C160892712 @default.
• W1998182907 hasConcept C162356407 @default.
• W1998182907 hasConcept C178790620 @default.
• W1998182907 hasConcept C185592680 @default.
• W1998182907 hasConcept C204787440 @default.
• W1998182907 hasConcept C2776910235 @default.
• W1998182907 hasConcept C40684141 @default.
• W1998182907 hasConcept C43617362 @default.
• W1998182907 hasConcept C62520636 @default.
• W1998182907 hasConcept C71924100 @default.
• W1998182907 hasConcept C75473681 @default.

• next