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- W1998192085 abstract "Abstract Over the past decade, extracellular nucleotides (such as ATP and UTP) have emerged as key immunomodulators. This family of molecules, already known for its key metabolic functions, has been the focus of intense investigation that has unambiguously shown its crucial role as mediators of cell-to-cell communication. More recently, in addition to its involvement in inflammation and immunity, purinergic signaling has also been shown to modulate BM-derived stem cells. Extracellular nucleotides promote proliferation, CXCL12-driven migration, and BM engraftment of hematopoietic progenitor and stem cells. In addition, purinergic signaling acts indirectly on hematopoietic progenitor and stem cells by regulating differentiation and release of proinflammatory cytokines in BM-derived human mesenchymal stromal cells, which are part of the hematopoietic stem cell (HSC) niche. HSC research has recently blended into the field of immunology, as new findings highlighted the role played by immunologic signals (such as IFN-α, IFN-γ, or TNF-α) in the regulation of the HSC compartment. In this review, we summarize recent reports unveiling a previously unsuspected ability of HSCs to integrate inflammatory signals released by immune and stromal cells, with particular emphasis on the dual role of extracellular nucleotides as mediators of both immunologic responses and BM stem cell functions." @default.
- W1998192085 created "2016-06-24" @default.
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- W1998192085 date "2012-09-20" @default.
- W1998192085 modified "2023-10-16" @default.
- W1998192085 title "The sixth sense: hematopoietic stem cells detect danger through purinergic signaling" @default.
- W1998192085 cites W1482852619 @default.
- W1998192085 cites W1517940049 @default.
- W1998192085 cites W1532386517 @default.
- W1998192085 cites W1553577256 @default.
- W1998192085 cites W1570302914 @default.
- W1998192085 cites W1590900769 @default.
- W1998192085 cites W1602068304 @default.
- W1998192085 cites W180620693 @default.
- W1998192085 cites W1964273856 @default.
- W1998192085 cites W1965130745 @default.
- W1998192085 cites W1966898859 @default.
- W1998192085 cites W1967979864 @default.
- W1998192085 cites W1971817436 @default.
- W1998192085 cites W1973099013 @default.
- W1998192085 cites W1976006181 @default.
- W1998192085 cites W1977187462 @default.
- W1998192085 cites W1980927246 @default.
- W1998192085 cites W1981424925 @default.
- W1998192085 cites W1982420774 @default.
- W1998192085 cites W1983009411 @default.
- W1998192085 cites W1985407729 @default.
- W1998192085 cites W1985927027 @default.
- W1998192085 cites W1988951550 @default.
- W1998192085 cites W1989311627 @default.
- W1998192085 cites W1993229072 @default.
- W1998192085 cites W1995810932 @default.
- W1998192085 cites W1998545579 @default.
- W1998192085 cites W1999493948 @default.
- W1998192085 cites W2002039081 @default.
- W1998192085 cites W2002811082 @default.
- W1998192085 cites W2011059916 @default.
- W1998192085 cites W2011060501 @default.
- W1998192085 cites W2012461372 @default.
- W1998192085 cites W2014193540 @default.
- W1998192085 cites W2015255171 @default.
- W1998192085 cites W2015506762 @default.
- W1998192085 cites W2020013385 @default.
- W1998192085 cites W2022293913 @default.
- W1998192085 cites W2023012797 @default.
- W1998192085 cites W2025705866 @default.
- W1998192085 cites W2027927113 @default.
- W1998192085 cites W2028017703 @default.
- W1998192085 cites W2028437799 @default.
- W1998192085 cites W2029445599 @default.
- W1998192085 cites W2031434196 @default.
- W1998192085 cites W2034175553 @default.
- W1998192085 cites W2034321048 @default.
- W1998192085 cites W2034442219 @default.
- W1998192085 cites W2038727217 @default.
- W1998192085 cites W2041292257 @default.
- W1998192085 cites W2042645266 @default.
- W1998192085 cites W2042906495 @default.
- W1998192085 cites W2045576152 @default.
- W1998192085 cites W2050434108 @default.
- W1998192085 cites W2050771850 @default.
- W1998192085 cites W2050948440 @default.
- W1998192085 cites W2051238731 @default.
- W1998192085 cites W2052904272 @default.
- W1998192085 cites W2057216006 @default.
- W1998192085 cites W2059177056 @default.
- W1998192085 cites W2059476255 @default.
- W1998192085 cites W2066502054 @default.
- W1998192085 cites W2068517470 @default.
- W1998192085 cites W2070663123 @default.
- W1998192085 cites W2072023433 @default.
- W1998192085 cites W2072411272 @default.
- W1998192085 cites W2078395354 @default.
- W1998192085 cites W2085167407 @default.
- W1998192085 cites W2086350471 @default.
- W1998192085 cites W2086969890 @default.
- W1998192085 cites W2087143957 @default.
- W1998192085 cites W2087919417 @default.
- W1998192085 cites W2088652745 @default.
- W1998192085 cites W2091907611 @default.
- W1998192085 cites W2093420037 @default.
- W1998192085 cites W2094133105 @default.
- W1998192085 cites W2098976226 @default.
- W1998192085 cites W2099508116 @default.
- W1998192085 cites W2100452437 @default.
- W1998192085 cites W2115016018 @default.
- W1998192085 cites W2123215772 @default.
- W1998192085 cites W2123870112 @default.
- W1998192085 cites W2124011290 @default.
- W1998192085 cites W2124139677 @default.
- W1998192085 cites W2127855108 @default.
- W1998192085 cites W2129388928 @default.
- W1998192085 cites W2129667982 @default.
- W1998192085 cites W2135399946 @default.