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• W1998192103 abstract "In this paper, we developed a low-cost intracellular delivery system based on microbubble and high gravity field. We successfully delivered FITC-Dextran (40kD) into hard-to-deliver THP-1 cells. The results showed that our method achieved high delivery efficiency up to 80%. It was found that the delivery efficiency and cell viability were closely related to the centrifuge speed. We speculated that the burst of microbubbles causes transient pore opening thus increasing the chance of biomolecules entering cells. This fast, low-cost and easy-to-operate protocol is very promising for delivering therapeutic genes and drugs into any cells which do not actively take up extracellular materials. This method is most effective for in-vitro delivery, but after delivery, treated cells might be injected back to human for in-vivo imaging." @default.
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• W1998192103 date "2012-08-01" @default.
• W1998192103 modified "2023-09-25" @default.
• W1998192103 title "A low-cost intracellular delivery system based on microbubble and high gravity field" @default.
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• W1998192103 doi "https://doi.org/10.1109/embc.2012.6346453" @default.
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