FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998201540> ?p ?o ?g. }

• W1998201540 endingPage "666" @default.
• W1998201540 startingPage "659" @default.
• W1998201540 abstract "Clinical studies suggest that plasma levels of risperidone and its active moiety (risperidone + 9-hydroxyrisperidone) correlate with adverse drug effects. The aim of this study is to evaluate the pharmacogenetic variability in the disposition of risperidone and the active moiety in healthy Chinese subjects. A 2-mg single dose of risperidone is orally administered to 23 healthy Chinese subjects. The risperidone and 9-hydroxyrisperidone serum concentrations are measured. The polymorphic alleles of CYP2D6*10, CYP3A5*3, MDR1 C1236T, G2677T/A, and C3435T are determined in each subject. The mean maximum plasma concentration and area under the time-concentration curve extrapolated to infinity for risperidone are significantly higher in subjects possessing the CYP2D6*10 allele than in those with the CYP2D6*1/*1 and *1/*10 genotype. For active moiety, the subjects who carry both homozygous CYP2D6*10 and homozygous CYP3A5*3 have 98% higher area under the time-concentration curve extrapolated to infinity and 59% higher maximum plasma concentration compared with other CYP2D6 EM subjects. The MDR1 2677GA genotype may also play a role in risperidone pharmacokinetics. Further studies are needed to explore the impact of MDR1 2677GA and CYP3A5 polymorphisms on risperidone therapy." @default.
• W1998201540 created "2016-06-24" @default.
• W1998201540 creator A5041509417 @default.
• W1998201540 creator A5054115062 @default.
• W1998201540 creator A5062487012 @default.
• W1998201540 creator A5065558630 @default.
• W1998201540 creator A5070592358 @default.
• W1998201540 date "2010-06-01" @default.
• W1998201540 modified "2023-10-07" @default.
• W1998201540 title "Effect of CYP2D6, CYP3A5, and MDR1 Genetic Polymorphisms on the Pharmacokinetics of Risperidone and Its Active Moiety" @default.
• W1998201540 cites W1894997478 @default.
• W1998201540 cites W1969738024 @default.
• W1998201540 cites W1979587548 @default.
• W1998201540 cites W1979902556 @default.
• W1998201540 cites W1981367166 @default.
• W1998201540 cites W1991218028 @default.
• W1998201540 cites W2002345475 @default.
• W1998201540 cites W2007530394 @default.
• W1998201540 cites W2012554561 @default.
• W1998201540 cites W2021034741 @default.
• W1998201540 cites W2029995473 @default.
• W1998201540 cites W2034295073 @default.
• W1998201540 cites W2036912651 @default.
• W1998201540 cites W2041253701 @default.
• W1998201540 cites W2041959054 @default.
• W1998201540 cites W2054458932 @default.
• W1998201540 cites W2055609884 @default.
• W1998201540 cites W2062106705 @default.
• W1998201540 cites W2063392573 @default.
• W1998201540 cites W2066919313 @default.
• W1998201540 cites W2067807895 @default.
• W1998201540 cites W2075080526 @default.
• W1998201540 cites W2080185803 @default.
• W1998201540 cites W2082034987 @default.
• W1998201540 cites W2084141010 @default.
• W1998201540 cites W2089753359 @default.
• W1998201540 cites W2092780491 @default.
• W1998201540 cites W2105902511 @default.
• W1998201540 cites W2108982217 @default.
• W1998201540 cites W2114098531 @default.
• W1998201540 cites W2118342649 @default.
• W1998201540 cites W2132976616 @default.
• W1998201540 cites W2157049173 @default.
• W1998201540 doi "https://doi.org/10.1177/0091270009347867" @default.
• W1998201540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20332423" @default.
• W1998201540 hasPublicationYear "2010" @default.
• W1998201540 type Work @default.
• W1998201540 sameAs 1998201540 @default.
• W1998201540 citedByCount "80" @default.
• W1998201540 countsByYear W19982015402012 @default.
• W1998201540 countsByYear W19982015402013 @default.
• W1998201540 countsByYear W19982015402014 @default.
• W1998201540 countsByYear W19982015402015 @default.
• W1998201540 countsByYear W19982015402016 @default.
• W1998201540 countsByYear W19982015402017 @default.
• W1998201540 countsByYear W19982015402018 @default.
• W1998201540 countsByYear W19982015402019 @default.
• W1998201540 countsByYear W19982015402020 @default.
• W1998201540 countsByYear W19982015402021 @default.
• W1998201540 countsByYear W19982015402022 @default.
• W1998201540 crossrefType "journal-article" @default.
• W1998201540 hasAuthorship W1998201540A5041509417 @default.
• W1998201540 hasAuthorship W1998201540A5054115062 @default.
• W1998201540 hasAuthorship W1998201540A5062487012 @default.
• W1998201540 hasAuthorship W1998201540A5065558630 @default.
• W1998201540 hasAuthorship W1998201540A5070592358 @default.
• W1998201540 hasConcept C104317684 @default.
• W1998201540 hasConcept C112705442 @default.
• W1998201540 hasConcept C118552586 @default.
• W1998201540 hasConcept C126322002 @default.
• W1998201540 hasConcept C135763542 @default.
• W1998201540 hasConcept C149151106 @default.
• W1998201540 hasConcept C170493617 @default.
• W1998201540 hasConcept C2776412080 @default.
• W1998201540 hasConcept C2776885963 @default.
• W1998201540 hasConcept C2780057945 @default.
• W1998201540 hasConcept C2781353949 @default.
• W1998201540 hasConcept C33664856 @default.
• W1998201540 hasConcept C526171541 @default.
• W1998201540 hasConcept C54355233 @default.
• W1998201540 hasConcept C55775858 @default.
• W1998201540 hasConcept C62231903 @default.
• W1998201540 hasConcept C71924100 @default.
• W1998201540 hasConcept C86803240 @default.
• W1998201540 hasConcept C92137452 @default.
• W1998201540 hasConcept C98274493 @default.
• W1998201540 hasConceptScore W1998201540C104317684 @default.
• W1998201540 hasConceptScore W1998201540C112705442 @default.
• W1998201540 hasConceptScore W1998201540C118552586 @default.
• W1998201540 hasConceptScore W1998201540C126322002 @default.
• W1998201540 hasConceptScore W1998201540C135763542 @default.
• W1998201540 hasConceptScore W1998201540C149151106 @default.
• W1998201540 hasConceptScore W1998201540C170493617 @default.
• W1998201540 hasConceptScore W1998201540C2776412080 @default.
• W1998201540 hasConceptScore W1998201540C2776885963 @default.
• W1998201540 hasConceptScore W1998201540C2780057945 @default.
• W1998201540 hasConceptScore W1998201540C2781353949 @default.
• W1998201540 hasConceptScore W1998201540C33664856 @default.

• next