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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998201703> ?p ?o ?g. }

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• W1998201703 abstract "The discovery of a novel class of nitric oxide synthase (NOS) inhibitors, 2-substituted 1,2-dihydro-4-quinazolinamines, and the related 4'-aminospiro[piperidine-4,2'(1'H)-quinazolin]-4'-amines is described. Members of both series exhibit nanomolar potency and high selectivity for the inducible isoform of the enzyme (i-NOS) relative to the constitutive isoforms in vitro. Efficacy in acute and chronic animal models of inflammatory disease following oral administration has also been demonstrated using these compounds." @default.
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• W1998201703 date "2003-02-07" @default.
• W1998201703 modified "2023-09-24" @default.
• W1998201703 title "1,2-Dihydro-4-quinazolinamines: Potent, Highly Selective Inhibitors of Inducible Nitric Oxide Synthase Which Show Antiinflammatory Activity in Vivo" @default.
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• W1998201703 doi "https://doi.org/10.1021/jm0255926" @default.
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