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- W1998211437 abstract "Abstract A study designed to determine whether humoral antibodies and a cell-mediated immune response to sperm antigen(s) in rhesus monkeys after unilateral and bilateral vas ligations has revealed negative findings. Kibrick agglutination, indirect hemagglutination, and sperm immobilization tests on pre- and postvasectomy sera obtained at timed intervals of one to one hundred and two weeks indicated that significant sperm agglutinating, hemagglutinating, and immobilizing antibodies did not develop in these animals. Also, lymphocyte transformation studies showed that a significant cellular antibody response to sperm antigen(s) did not develop in vasectomized animals. Furthermore, sera from rhesus monkeys injected with autologous and homologous washed sperm in Freund's adjuvant failed to demonstrate a positive reaction in agglutination and immobilization tests. On the other hand, immunization of a female rhesus monkey with washed sperm in Freund's adjuvant produced high titer sperm agglutinating and immobilizing antibodies. Therefore, it has not been possible to repeat or contribute supporting data to literature reports concerning the presence of antibodies to sperm in vasectomized rhesus monkeys. It is further suggested that a number of antigens unrelated to sperm might react with sera obtained from vasectomized animals and lead to positive findings in sperm agglutination and immobilization tests. As a result, erroneous conclusions may be drawn about the development of antibodies specific for sperm in vasectomized rhesus monkeys. Definitive conclusions concerning the development of specific antibodies to sperm antigens after vasectomy will be possible only when sperm antigens have been isolated, purified, and chemically and immunologically characterized for use in serologic tests." @default.
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- W1998211437 date "1977-06-01" @default.
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- W1998211437 title "Vasectomy in rhesus monkeys II. Failure to demonstrate humoral and cellular immune responses specific for sperm" @default.
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- W1998211437 doi "https://doi.org/10.1016/0090-4295(77)90311-9" @default.
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