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• W1998214900 abstract "To compare the metabolic effects of indapamide (I) and hydrochlorothiazide (HCTZ) at equivalent hypotensive doses, 11 hypertensive patients (5 male, 8 black, aged 56 ± 8 yr — mean ± SEM) having serum uric acid concentrations >8.0 mg/dL while receiving previous therapy with thiazides, received 28-day courses of placebo, indapamide (2.5 mg/d), and HCTZ (25 mg/d) in randomized, double-blind, double-crossover design. Supine and standing blood pressures, weight, pulse rates and sera were obtained after each 28 day period. Blood pressures and weights were lowered (P <.001 and 0.01, respectively) equally by the diuretics: supine blood pressures fell from 168 ± 4/104 ± 2 (placebo) to 153 ± 4/93 ± 2 (HCTZ) and 155 ± 4/94 ± 2 mm Hg (I); standing blood pressures (after 2 minutes upright) also decreased: 171 ± 5/104 ± 2 (placebo) to 156 ± 5/93 ± 2 (HCTZ) and 157 ± 4/94 ± 2 mm Hg (I). There was a statistically significant difference (P <.05) across treatments by analysis of variance in both uric acid and potassium concentrations: serum urate (in mg/dL) was lowest with placebo (7.1 ± 0.3), and rose to 8.3 ± 0.2 with HCTZ (P <.001 compared with placebo by paired t test), and 8.1 ± 0.2 with I (P <.005 vs. placebo). The urate concentration with I was significantly lower than that with HCTZ (P <.02), but the magnitude of the difference was small (0.2 mg/dL). Serum potassium (mmol/L) was lower on each diuretic than that with placebo (4.2 ± 0.1, P <.005 for each), but not different between diuretics (HCTZ: 3.8 ±0.1; I: 3.9 ±0.1). No other significant differences were found in biochemical indices between therapies. Thus, at equihypotensive (i.e., low) doses in patients known to have elevated serum-urate concentrations with thiazides, indapamide may cause less hyperuricemia than HCTZ. Although statistically significant, this difference is of questionable clinical importance, since both diuretics raise serum-urate concentrations relative to placebo." @default.
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• W1998214900 date "1991-08-01" @default.
• W1998214900 modified "2023-10-14" @default.
• W1998214900 title "A Double-Blind, Randomized, Placebo-Controlled Comparison of the Metabolic Effects of Low-Dose Hydrochlorothiazide and Indapamide" @default.
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• W1998214900 doi "https://doi.org/10.1002/j.1552-4604.1991.tb03772.x" @default.
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