FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998214913> ?p ?o ?g. }

• W1998214913 endingPage "644" @default.
• W1998214913 startingPage "635" @default.
• W1998214913 abstract "Stable tubule-only polypeptide (STOP) proteins are a family of microtubule associated proteins (MAPs) important in microtubule stabilization. Data indicating a role for microtubules in synaptic function has come from studies of the STOP null mouse, which exhibits synaptic deficits, in association with behavioural changes that are alleviated by antipsychotic treatment. These findings suggested that STOP mutant mice may be useful in studies of synaptic function, and could be especially relevant to schizophrenia, postulated to be a disorder of the synapse. Moreover, a genetic association between STOP and schizophrenia has been reported. This study aimed to further characterize synaptic alterations in STOP null and heterozygous mice. Using in situ hybridization histochemistry, the mRNA expression of three pre-synaptic (synaptophysin; growth associated protein-43 (GAP-43); vesicular glutamate transporter-1 (VGlut1)) and two post-synaptic (spinophilin; MAP2) proteins, was quantified in female STOP null ( n = 7), heterozygous ( n = 5) and wild type ( n = 6) mice. For STOP null and heterozygous mice, synaptophysin, VGlut1, GAP-43 and spinophilin mRNAs were decreased in the hippocampus, whilst in addition in the null mice, synaptophysin, VGlut1 and spinophilin mRNAs were decreased in the cerebellum. Alterations in synaptic protein mRNA expression were also detected in the frontal and occipital cortex. MAP2 mRNA expression was unchanged in all brain regions. The profile of mRNA changes is broadly similar to that observed in schizophrenia. Together the data provide supporting evidence for a role for microtubules in synaptic function, and suggest that STOP, or other microtubule proteins, may contribute to the synaptic pathology of schizophrenia." @default.
• W1998214913 created "2016-06-24" @default.
• W1998214913 creator A5019903602 @default.
• W1998214913 creator A5042966659 @default.
• W1998214913 creator A5050681797 @default.
• W1998214913 creator A5053951121 @default.
• W1998214913 creator A5062928277 @default.
• W1998214913 creator A5073948730 @default.
• W1998214913 date "2006-11-08" @default.
• W1998214913 modified "2023-09-25" @default.
• W1998214913 title "Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice" @default.
• W1998214913 cites W1532388773 @default.
• W1998214913 cites W1583142746 @default.
• W1998214913 cites W1589731099 @default.
• W1998214913 cites W1885585690 @default.
• W1998214913 cites W1907092125 @default.
• W1998214913 cites W1960099260 @default.
• W1998214913 cites W1963490696 @default.
• W1998214913 cites W1965118964 @default.
• W1998214913 cites W1967443916 @default.
• W1998214913 cites W1971696611 @default.
• W1998214913 cites W1975586358 @default.
• W1998214913 cites W1977805593 @default.
• W1998214913 cites W1978505405 @default.
• W1998214913 cites W1980149320 @default.
• W1998214913 cites W1983863521 @default.
• W1998214913 cites W1989901971 @default.
• W1998214913 cites W1990483753 @default.
• W1998214913 cites W1991059302 @default.
• W1998214913 cites W1991130171 @default.
• W1998214913 cites W1992423329 @default.
• W1998214913 cites W1992902151 @default.
• W1998214913 cites W1995673433 @default.
• W1998214913 cites W2002192892 @default.
• W1998214913 cites W2005096312 @default.
• W1998214913 cites W2006511914 @default.
• W1998214913 cites W2006628753 @default.
• W1998214913 cites W2006955548 @default.
• W1998214913 cites W2007742115 @default.
• W1998214913 cites W2008172722 @default.
• W1998214913 cites W2010659088 @default.
• W1998214913 cites W2011815988 @default.
• W1998214913 cites W2012648981 @default.
• W1998214913 cites W2017350971 @default.
• W1998214913 cites W2019893594 @default.
• W1998214913 cites W2021366646 @default.
• W1998214913 cites W2027842970 @default.
• W1998214913 cites W2028474222 @default.
• W1998214913 cites W2028636372 @default.
• W1998214913 cites W2029120000 @default.
• W1998214913 cites W2030878563 @default.
• W1998214913 cites W2046013073 @default.
• W1998214913 cites W2049147617 @default.
• W1998214913 cites W2051300829 @default.
• W1998214913 cites W2051420506 @default.
• W1998214913 cites W2054127658 @default.
• W1998214913 cites W2056954673 @default.
• W1998214913 cites W2058917641 @default.
• W1998214913 cites W2060642455 @default.
• W1998214913 cites W2061292068 @default.
• W1998214913 cites W2062470404 @default.
• W1998214913 cites W2064794127 @default.
• W1998214913 cites W2065918017 @default.
• W1998214913 cites W2066874327 @default.
• W1998214913 cites W2067237160 @default.
• W1998214913 cites W2068528631 @default.
• W1998214913 cites W2082074451 @default.
• W1998214913 cites W2082692141 @default.
• W1998214913 cites W2087592242 @default.
• W1998214913 cites W2088720667 @default.
• W1998214913 cites W2088793971 @default.
• W1998214913 cites W2089467861 @default.
• W1998214913 cites W2091299458 @default.
• W1998214913 cites W2097088842 @default.
• W1998214913 cites W2099636437 @default.
• W1998214913 cites W2105575850 @default.
• W1998214913 cites W2107806372 @default.
• W1998214913 cites W2115346246 @default.
• W1998214913 cites W2120698866 @default.
• W1998214913 cites W2122694225 @default.
• W1998214913 cites W2122715226 @default.
• W1998214913 cites W2128646985 @default.
• W1998214913 cites W2129167450 @default.
• W1998214913 cites W2130555830 @default.
• W1998214913 cites W2131679574 @default.
• W1998214913 cites W2142286619 @default.
• W1998214913 cites W2143347013 @default.
• W1998214913 cites W2149348969 @default.
• W1998214913 cites W2159146588 @default.
• W1998214913 cites W2757560864 @default.
• W1998214913 cites W4254271181 @default.
• W1998214913 cites W4256060828 @default.
• W1998214913 cites W44954597 @default.
• W1998214913 doi "https://doi.org/10.1177/0269881106068825" @default.
• W1998214913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17050659" @default.
• W1998214913 hasPublicationYear "2006" @default.
• W1998214913 type Work @default.
• W1998214913 sameAs 1998214913 @default.

• next