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• W1998215958 abstract "<i>Background/Aims:</i> Peritoneal fibrosis is a serious complication of peritoneal dialysis (PD). It has been reported that administration of mizoribine, an effective immunosuppressant, ameliorated renal fibrosis in a rat model of unilateral ureteral obstruction. We therefore examined the effects of mizoribine in an experimental model of peritoneal fibrosis. <i>Methods:</i> 24 rats were given a daily intraperitoneal injection of chlorhexidine gluconate and ethanol dissolved in saline. The rats were divided into three groups (n = 8 per group) that received either vehicle or mizoribine at a dose of 2 or 8 mg/kg once a day. 28 days after the start of the treatments the rats were sacrificed and peritoneal tissue samples collected. Macrophage infiltration (ED1), myofibroblast accumulation (α-smooth muscle actin (SMA)) and expression of type III collagen, transforming growth factor (TGF)-β and monocyte chemotactic protein-1 (MCP-1) were examined by immunohistochemistry. <i>Results:</i> Mizoribine significantly suppressed submesothelial zone thickening and reduced macrophage infiltration. Mizoribine also reduced collagen III⁺ area and decreased the number of α-SMA⁺, TGF-β⁺ and MCP-1⁺ cells. The magnitude of the changes observed was dose-dependent. <i>Conclusion:</i> The administration of mizoribine prevented the progression of peritoneal fibrosis in this rat model. Mizoribine may represent a novel therapy for peritoneal sclerosis in patients undergoing long-term PD." @default.
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• W1998215958 date "2009-01-01" @default.
• W1998215958 modified "2023-10-18" @default.
• W1998215958 title "Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model" @default.
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• W1998215958 doi "https://doi.org/10.1159/000213896" @default.
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