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• W1998222854 endingPage "414" @default.
• W1998222854 startingPage "406" @default.
• W1998222854 abstract "ATP-binding cassette (ABC) transporters play a pivotal role in human physiology, and mutations in these genes often result in severe hereditary diseases. ABC transporters are expressed in the bovine mammary gland but their physiological role in this organ remains elusive. Based on findings in the context of human disorders we speculated that candidate ABC transporters are implicated in lipid and cholesterol transport in the mammary gland. Therefore we investigated the expression pattern of selected genes that are associated with sterol transport in lactating and nonlactating mammary glands of dairy cows. mRNA levels from mammary gland biopsies taken during lactation and in the first and second week of the dry period were analysed using quantitative PCR. Five ABC transporter genes, namely ABCA1 , ABCA7 , ABCG1 , ABCG2 and ABCG5 , their regulating genes LXRα , PPARγ , SREBP1 and the milk proteins lactoferrin and α-lactalbumin were assessed. A significantly enhanced expression in the dry period was observed for ABCA1 while a significant decrease of expression in this period was detected for ABCA7 , ABCG2, SREBP1 and α-lactalbumin. ABCG1 , ABCG5 , LXRα , PPARγ and lactoferrin expression was not altered between lactation and dry period. These results indicate that candidate ABC transporters involved in lipid and cholesterol transport show differential mRNA expression between lactation and the dry period. This may be due to physiological changes in the mammary gland such as immigration of macrophages or the accumulation of fat due to the loss of liquid in the involuting mammary gland. The current mRNA expression analysis of transporters in the mammary gland is the prerequisite for elucidating novel molecular mechanisms underlying cholesterol and lipid transfer into milk." @default.
• W1998222854 created "2016-06-24" @default.
• W1998222854 creator A5015725603 @default.
• W1998222854 creator A5040198877 @default.
• W1998222854 creator A5059928437 @default.
• W1998222854 creator A5091372465 @default.
• W1998222854 date "2008-08-14" @default.
• W1998222854 modified "2023-09-23" @default.
• W1998222854 title "Differential expression of ABC transporters and their regulatory genes during lactation and dry period in bovine mammary tissue" @default.
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• W1998222854 doi "https://doi.org/10.1017/s002202990800335x" @default.
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