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• W1998238082 endingPage "12526" @default.
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• W1998238082 abstract "The isolation of hematopoietic stem and progenitor cells (HSPCs) is critical for transplantation therapy and HSPC research, however current isolation techniques can be prohibitively expensive, time-consuming, and produce variable results. Selectin-coated microtubes have shown promise in rapidly isolating HSPCs from human bone marrow, but further purification of HSPCs remains a challenge. Herein, a biomimetic device for HSPC isolation is presented to mimic the acidic vascular microenvironment during trauma, which can enhance the binding frequency between L-selectin and its counter-receptor PSGL-1 and HSPCs. Under acidic pH conditions, L-selectin coated microtubes enhanced CD34+ HSPC adhesion, as evidenced by decreased cell rolling velocity and increased rolling flux. Dynamic light scattering was utilized as a novel sensor to confirm an L-selectin conformational change under acidic conditions, as previously predicted by molecular dynamics. These results suggest that mimicking the acidic conditions of trauma can induce a conformational extension of L-selectin, which can be utilized for flow-based, clinical isolation of HSPCs." @default.
• W1998238082 created "2016-06-24" @default.
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• W1998238082 creator A5081005464 @default.
• W1998238082 date "2013-09-17" @default.
• W1998238082 modified "2023-09-26" @default.
• W1998238082 title "Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma" @default.
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• W1998238082 doi "https://doi.org/10.3390/s130912516" @default.
• W1998238082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3821329" @default.
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