Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998238462> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1998238462 endingPage "1566" @default.
- W1998238462 startingPage "1564" @default.
- W1998238462 abstract "Seasonal allergic rhinitis (SAR) is a disease of increasing prevalence, which results from an inappropriate T helper cell, type 2 (Th2) response to pollen. Specific immunotherapy (SIT) involves repeated treatment with small doses of pollen and can result in complete and lasting reversal of SAR. Here, we assayed the key Th2 cytokine, IL-4, and its soluble and membrane-bound receptor in patients with SAR before and after SIT. Using allergen-challenge assays, we found that SIT treatment decreased IL-4 cytokine levels, as previously reported. We also observed a significant decrease in the IL-4 membrane-bound receptor (mIL4R) at the level of both mRNA and protein. SIT treatment resulted in a significant increase in the inhibitory soluble IL-4 receptor (sIL4R). Reciprocal changes in mIL4R and sIL4R were also observed in patient serum. Altered mIL4R and sIL4R is a novel explanation for the positive effects of immunotherapy with potential basic and clinical research implications." @default.
- W1998238462 created "2016-06-24" @default.
- W1998238462 creator A5000753874 @default.
- W1998238462 creator A5024120345 @default.
- W1998238462 creator A5044385229 @default.
- W1998238462 creator A5049770857 @default.
- W1998238462 creator A5053080879 @default.
- W1998238462 creator A5062355961 @default.
- W1998238462 creator A5084550031 @default.
- W1998238462 date "2014-09-13" @default.
- W1998238462 modified "2023-10-06" @default.
- W1998238462 title "Sublingual immunotherapy alters expression of IL-4 and its soluble and membrane-bound receptors" @default.
- W1998238462 cites W1911339339 @default.
- W1998238462 cites W1995908153 @default.
- W1998238462 cites W2002998653 @default.
- W1998238462 cites W2005749129 @default.
- W1998238462 cites W2009893780 @default.
- W1998238462 cites W2012749263 @default.
- W1998238462 cites W2063112832 @default.
- W1998238462 cites W2078021268 @default.
- W1998238462 cites W2089644954 @default.
- W1998238462 cites W2128395048 @default.
- W1998238462 cites W2152767905 @default.
- W1998238462 cites W2154460881 @default.
- W1998238462 cites W2157455033 @default.
- W1998238462 cites W2167829087 @default.
- W1998238462 doi "https://doi.org/10.1111/all.12505" @default.
- W1998238462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25130266" @default.
- W1998238462 hasPublicationYear "2014" @default.
- W1998238462 type Work @default.
- W1998238462 sameAs 1998238462 @default.
- W1998238462 citedByCount "8" @default.
- W1998238462 countsByYear W19982384622015 @default.
- W1998238462 countsByYear W19982384622016 @default.
- W1998238462 countsByYear W19982384622022 @default.
- W1998238462 countsByYear W19982384622023 @default.
- W1998238462 crossrefType "journal-article" @default.
- W1998238462 hasAuthorship W1998238462A5000753874 @default.
- W1998238462 hasAuthorship W1998238462A5024120345 @default.
- W1998238462 hasAuthorship W1998238462A5044385229 @default.
- W1998238462 hasAuthorship W1998238462A5049770857 @default.
- W1998238462 hasAuthorship W1998238462A5053080879 @default.
- W1998238462 hasAuthorship W1998238462A5062355961 @default.
- W1998238462 hasAuthorship W1998238462A5084550031 @default.
- W1998238462 hasConcept C126322002 @default.
- W1998238462 hasConcept C1491633281 @default.
- W1998238462 hasConcept C170493617 @default.
- W1998238462 hasConcept C191732599 @default.
- W1998238462 hasConcept C203014093 @default.
- W1998238462 hasConcept C2777701055 @default.
- W1998238462 hasConcept C2778690821 @default.
- W1998238462 hasConcept C55493867 @default.
- W1998238462 hasConcept C71924100 @default.
- W1998238462 hasConcept C86803240 @default.
- W1998238462 hasConcept C8891405 @default.
- W1998238462 hasConceptScore W1998238462C126322002 @default.
- W1998238462 hasConceptScore W1998238462C1491633281 @default.
- W1998238462 hasConceptScore W1998238462C170493617 @default.
- W1998238462 hasConceptScore W1998238462C191732599 @default.
- W1998238462 hasConceptScore W1998238462C203014093 @default.
- W1998238462 hasConceptScore W1998238462C2777701055 @default.
- W1998238462 hasConceptScore W1998238462C2778690821 @default.
- W1998238462 hasConceptScore W1998238462C55493867 @default.
- W1998238462 hasConceptScore W1998238462C71924100 @default.
- W1998238462 hasConceptScore W1998238462C86803240 @default.
- W1998238462 hasConceptScore W1998238462C8891405 @default.
- W1998238462 hasFunder F4320321033 @default.
- W1998238462 hasIssue "11" @default.
- W1998238462 hasLocation W19982384621 @default.
- W1998238462 hasLocation W19982384622 @default.
- W1998238462 hasOpenAccess W1998238462 @default.
- W1998238462 hasPrimaryLocation W19982384621 @default.
- W1998238462 hasRelatedWork W1973157557 @default.
- W1998238462 hasRelatedWork W2094776015 @default.
- W1998238462 hasRelatedWork W3029386772 @default.
- W1998238462 hasRelatedWork W3093899576 @default.
- W1998238462 hasRelatedWork W3159716479 @default.
- W1998238462 hasRelatedWork W3216926328 @default.
- W1998238462 hasRelatedWork W4205138377 @default.
- W1998238462 hasRelatedWork W4206523383 @default.
- W1998238462 hasRelatedWork W4292999066 @default.
- W1998238462 hasRelatedWork W4307656996 @default.
- W1998238462 hasVolume "69" @default.
- W1998238462 isParatext "false" @default.
- W1998238462 isRetracted "false" @default.
- W1998238462 magId "1998238462" @default.
- W1998238462 workType "article" @default.