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- W1998240179 endingPage "1369" @default.
- W1998240179 startingPage "1356" @default.
- W1998240179 abstract "Pepino mosaic virus (PepMV) (family Alphaflexiviridae, genus Potexvirus) is a mechanically transmitted tomato pathogen that, over the last decade, has evolved from emerging to endemic worldwide. Here, two heat-shock cognate (Hsc70) isoforms were identified as part of the coat protein (CP)/Hsc70 complex in vivo, following full-length PepMV and CP agroinoculation. PepMV accumulation was severely reduced in Hsp70 virus-induced gene silenced and in quercetin-treated Nicotiana benthamiana plants. Similarly, in vitro–transcribed as well as virion RNA input levels were reduced in quercetin-treated protoplasts, suggesting an essential role for Hsp70 in PepMV replication. As for Potato virus X, the PepMV CP and triple gene-block protein 1 (TGBp1) self-associate and interact with each other in vitro but, unlike in the prototype, both PepMV proteins represent suppressors of transgene-induced RNA silencing with different modes of action; CP is a more efficient suppressor of RNA silencing, sequesters the silencing signal by preventing its spread to neighboring cells and its systemic movement. Here, we provide evidence for additional roles of the PepMV CP and host-encoded Hsp70 in viral infection, the first as a truly multifunctional protein able to specifically bind to a host chaperone and to counterattack an RNA-based defense mechanism, and the latter as an essential factor for PepMV infection." @default.
- W1998240179 created "2016-06-24" @default.
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- W1998240179 creator A5087201688 @default.
- W1998240179 date "2014-12-01" @default.
- W1998240179 modified "2023-10-14" @default.
- W1998240179 title "Multifaceted Capsid Proteins: Multiple Interactions Suggest Multiple Roles for <i>Pepino mosaic virus</i> Capsid Protein" @default.
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- W1998240179 doi "https://doi.org/10.1094/mpmi-07-14-0195-r" @default.
- W1998240179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25162316" @default.
- W1998240179 hasPublicationYear "2014" @default.
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