FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1998273669> ?p ?o ?g. }

• W1998273669 endingPage "105" @default.
• W1998273669 startingPage "94" @default.
• W1998273669 abstract "1. Roberto Gordillo, MD*2. Adrian Spitzer, MD† 1. *Postdoctoral Fellow2. †Professor of Pediatrics, Albert Einstein College of Medicine/Children's Hospital at Montefiore, Division of Pediatric Nephrology, Bronx, NYAfter completing this article, readers should be able to: 1. Explain the mechanism and the consequences of proteinuria.2. Make a presumptive diagnosis of minimal-change nephrotic syndrome.3. Interpret the signs associated with steroid resistance.4. Ascertain the timing and the indications for a kidney biopsy.5. Gauge the indications for referral to a pediatric nephrologist.6. Determine the adequacy of the therapy.7. Predict the disease course.The word “nephrosis” was introduced in the medical literature at the beginning of the 20th century in an attempt to distinguish diseases of the kidney characterized by exudation and proliferation from those characterized by inflammation (nephritis). As it became apparent that this is not a single disease, not even a group of related diseases, the term “nephrosis” was supplanted by “nephrotic syndrome.” The clinical features that characterize the nephrotic syndrome result from alterations of the glomerular capillary wall and consist of heavy proteinuria and hypoalbuminemia, often associated with edema and generalized hyperlipidemia.### Proteinuria and HypoalbuminemiaProteinuria is the result of alterations in the integrity of the glomerular filtration barrier. This barrier is composed of three layers in series: the fenestrated endothelium, the glomerular basement membrane, and the visceral glomerular epithelium, comprised of podocytes and their slit diaphragms. Podocyte is the name of the epithelial cell, and foot process is the segment of the cell that extends into the urinary space. (In the nephrotic syndrome, there is effacement of the foot process, but the rest of the cell usually is preserved.)Endothelial cells have numerous openings that are 70 to 100 nm in diameter, called fenestrae, which form a physical barrier for passage of macromolecules from plasma into the renal tubule. Electron microscopic studies led to the identification of negatively charged particles (heparan sulfate proteoglycans) in the glomerular basement membrane, which preclude the passage of anionic macromolecules, such as albumin. Removal of these …" @default.
• W1998273669 created "2016-06-24" @default.
• W1998273669 creator A5033373423 @default.
• W1998273669 creator A5056036483 @default.
• W1998273669 date "2009-03-01" @default.
• W1998273669 modified "2023-09-25" @default.
• W1998273669 title "The Nephrotic Syndrome" @default.
• W1998273669 cites W1940588772 @default.
• W1998273669 cites W1980517783 @default.
• W1998273669 cites W1986167294 @default.
• W1998273669 cites W1994069320 @default.
• W1998273669 cites W2021202287 @default.
• W1998273669 cites W2035610198 @default.
• W1998273669 cites W2038562585 @default.
• W1998273669 cites W2039537505 @default.
• W1998273669 cites W2085574022 @default.
• W1998273669 cites W2093256168 @default.
• W1998273669 cites W2094516036 @default.
• W1998273669 cites W2117628961 @default.
• W1998273669 cites W2127974114 @default.
• W1998273669 cites W2134425923 @default.
• W1998273669 cites W2151098851 @default.
• W1998273669 cites W4210848327 @default.
• W1998273669 cites W4238630369 @default.
• W1998273669 doi "https://doi.org/10.1542/pir.30-3-94" @default.
• W1998273669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19255123" @default.
• W1998273669 hasPublicationYear "2009" @default.
• W1998273669 type Work @default.
• W1998273669 sameAs 1998273669 @default.
• W1998273669 citedByCount "20" @default.
• W1998273669 countsByYear W19982736692012 @default.
• W1998273669 countsByYear W19982736692013 @default.
• W1998273669 countsByYear W19982736692015 @default.
• W1998273669 countsByYear W19982736692016 @default.
• W1998273669 countsByYear W19982736692017 @default.
• W1998273669 countsByYear W19982736692018 @default.
• W1998273669 countsByYear W19982736692020 @default.
• W1998273669 countsByYear W19982736692021 @default.
• W1998273669 countsByYear W19982736692022 @default.
• W1998273669 crossrefType "journal-article" @default.
• W1998273669 hasAuthorship W1998273669A5033373423 @default.
• W1998273669 hasAuthorship W1998273669A5056036483 @default.
• W1998273669 hasConcept C126322002 @default.
• W1998273669 hasConcept C16005928 @default.
• W1998273669 hasConcept C2778930706 @default.
• W1998273669 hasConcept C71924100 @default.
• W1998273669 hasConceptScore W1998273669C126322002 @default.
• W1998273669 hasConceptScore W1998273669C16005928 @default.
• W1998273669 hasConceptScore W1998273669C2778930706 @default.
• W1998273669 hasConceptScore W1998273669C71924100 @default.
• W1998273669 hasIssue "3" @default.
• W1998273669 hasLocation W19982736691 @default.
• W1998273669 hasLocation W19982736692 @default.
• W1998273669 hasOpenAccess W1998273669 @default.
• W1998273669 hasPrimaryLocation W19982736691 @default.
• W1998273669 hasRelatedWork W1995515455 @default.
• W1998273669 hasRelatedWork W2080531066 @default.
• W1998273669 hasRelatedWork W2402835770 @default.
• W1998273669 hasRelatedWork W2409789398 @default.
• W1998273669 hasRelatedWork W2748952813 @default.
• W1998273669 hasRelatedWork W2899084033 @default.
• W1998273669 hasRelatedWork W3031052312 @default.
• W1998273669 hasRelatedWork W3032375762 @default.
• W1998273669 hasRelatedWork W3129467360 @default.
• W1998273669 hasRelatedWork W4297184974 @default.
• W1998273669 hasVolume "30" @default.
• W1998273669 isParatext "false" @default.
• W1998273669 isRetracted "false" @default.
• W1998273669 magId "1998273669" @default.
• W1998273669 workType "article" @default.